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Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease


, : Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease. Gastroenterology Research and Practice 2015: 476041-476041

The diagnosis of Parkinson's disease (PD) relies on clinical features whereas pathological confirmation is only possible with autopsy examination. The neuropathological hallmarks of PD are neuronal loss and the presence of inclusions termed Lewy bodies/neurites in affected regions. A major component of these inclusions is phosphorylated alpha-synuclein (α-SYN) protein. There is evidence that α-SYN pathology is widely distributed outside the central nervous system in patients with PD. The gastrointestinal tract is importantly affected by α-SYN containing inclusions and typically there is a rostrocaudal gradient for the distribution of the pathology. The highest amounts of Lewy bodies/neurites are found at the submandibular gland together with the lower esophagus and the lowest amounts are found in the rectum. Autopsy findings prompted research aimed at achieving in vivo pathological diagnosis of PD by demonstrating the presence of α-SYN pathology in biopsy material of these peripheral accessible tissues. So far, biopsy studies of the gut have demonstrated the presence of α-SYN pathology in the salivary glands, stomach, duodenum, colon, and rectum. Further research is necessary in order to determine which are the most sensitive targets for in vivo α-SYN pathology detection and the safest techniques for these approaches in patients with PD.

US$19.90

PMID: 26078752

DOI: 10.1155/2015/476041


Other references

Müller, S.C.; Bastian, P.J., 2007: The history of ureterosigmoidostomy. Congenital anomalies like bladder exstrophy were the indication in 1821 to implant the ureters into the sigmoid colon for the first time. In 1894 the Maydl technique was used more frequently with a postoperative mortality rate of 31%. The most imp...

Thanikachalam, M.; Sundararaj, A.; Manohar, B.M., 1979: An outbreak of coccidiosis in fowls. An outbreak of coccidiosis due to Eimeria brunetti, involving the ileum and rectum, was observed in fowls on a poultry farm near Madras, India. It killed 164 hens in 4 days but was controlled by Codrinal and antibiotics.

Macleod R.D., 1990: Lateral root primordium inception in zea mays l. Counts of the frequency and estimates of cell number of primordia present in successive segments of the primary roots of Zea mays L. have been used to investigate the initiation and distribution of primordia along the root axis. Primordium incepti...

Chen, G.C., 1994: Fungal decay resistance of wood reacted with chlorosulfonyl isocyanate or epichlorohydrin. The objective of this study was to investigate the reactions between wood and chlorosulfonyl isocyanate or epichlorohydrin and to determine fungal resistance of the treated wood. Loblolly pine (Pinus taeda) reacted with chlorosulfonyl isocyanate t...

Hrimiuc, M.; Hrimiuc, V., 2015: Medical correlations between general patology and oral cavity. The dento-maxillary system is, both in its development and in the maintainance of is integrity, in a close interdependence with the general state of the body, the deficitary enzymatic metabolic and immunologic alterations occuring during the evolu...

Keith, T.S., 1932: Bacteriological Standards for Milk and Ice-Cream. III. This annotation deals with the unsatisfactory state of the law as it stands at present with regard to bacteriological standards for milk, as revealed at a joint meeting of the Society of Chemical Industry and the Metropolitan Branch of the So...

Grigg-Damberger, M.M.; Wolfe, K.M., 2017: Infants Sleep for Brain. Journal of Clinical Sleep Medicine 13(11): 1233-1234

Murata, M.; Bhuta, P.; Owens, J.; Zemlicka, J., 1980: Inhibition of ribosomal peptidyltransferase with 2'(3')-O-acetyl-2 inches(3 inches)-O-glycyl-1,2-di(adenosin-N6-yl)ethane and -1,4-di(adenosin-N6-yl)butane. Effect of alkyl chain length. Journal of Medicinal Chemistry 23(7): 781-786

DeMarchis, E.H.; Pershing, S.; Moshfeghi, D.M., 2014: Clinical-pathologic correlation: vitrectomy with epiretinal and internal limiting membrane peel. To correlate clinical and pathologic findings in vitreoretinal surgeries with epiretinal membrane (ERM) and internal limiting membrane (ILM) peels. A retrospective review of the clinical and pathologic reports for 698 vitrectomy specimens involvin...

Moriondo, F., 1958: A serious threat to Italian Pine forests: blister rust on bark.. Discusses various conditions that might account for attacks by Cronartium asclepiadeum on Pinus pinaster and P. halepensis in certain forests in Tuscany.