geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans


, : Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans. Plos One 11(9): E0163421-E0163421

The metabolic syndrome (MetS) is a cluster of metabolic abnormalities and cardiovascular risk factors that are highly heritable and polygenic. We investigated the association of allelic variants of three candidate genes, rs1799883-FABP2, rs1501299-ADIPOQ and rs5065-ANP with MetS and its components, individually and in combination, using a genetic risk score. A cross-sectional study was conducted in 462 Afro-Caribbeans subjects without cardiovascular complications or lipid-lowering medications. Cardiovascular risk factors and MetS components (NCEP-ATPIII criteria) were recorded. The 3 SNPs were genotyped. The genetic risk score was calculated by summing the number of risk alleles at each locus. Logistic regressions were used. Fifty-eight participants (12.6%) were diabetics and 116 (25.1%) had a MetS. In a dominant model, rs1799883 was associated with hypertriglyceridemia (OR 2.22; P = 0.014) and hypertriglyceridemic waist (HTGW), (P = 0.014) but not significantly with overweight (P = 0.049), abdominal obesity (P = 0.033) and MetS (P = 0.068). In a dominant model, the OR of MetS and HTGW for rs1501299 were 1.80 (P = 0.028) and 2.19 (P = 0.040) respectively. In a recessive model, the OR of hypertriglyceridemia for rs5065 was 1.94 (P = 0.075). The genetic risk score was significantly associated with MetS. Subjects carrying 4-5 risk alleles (18.8%) had a nearly 2.5-fold-increased risk of MetS compared to those carrying 0-1 risk allele (24.3%): OR 2.31; P = 0.025. This study supports the association of FABP2, ANP and ADIPOQ gene variants with MetS or its components in Afro-Caribbeans and suggests a cumulative genetic influence of theses variants on this syndrome and a potential effect on lipid metabolism.

US$19.90

PMID: 27684940

DOI: 10.1371/journal.pone.0163421


Other references

Kabat, G.C.; Kim, M.Y.; Woods, N.F.; Habel, L.A.; Messina, C.R.; Wactawski-Wende, J.; Stefanick, M.L.; Chlebowski, R.T.; Wassertheil-Smoller, S.; Rohan, T.E., 2012: Reproductive and menstrual factors and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. The contribution of menstrual and reproductive factors to risk of ductal carcinoma (DCIS) of the breast is poorly understood.The association between menstrual and reproductive factors and subsequent DCIS risk was examined in Women s Health Initiat...

Simcik, S.R.; Underwood, H.T., 1996: Gastrointestinal helminths from juvenile red drum, Sciaenops ocellatus, and Atlantic croaker, Micropogonias undulatus , in East Matagorda Bay, Texas. Juvenile Sciaenops ocellatus (N = 20) and Micropogonias undulatus (N = 8) from East Matagorda Bay, Texas, were examined for gastrointestinal helminths. A total of 7 parasite species or groups were recovered, 5 of which were common to both S. ocell...

Zolotovc, G., 1960: A colour spot test for peppermint oil for peppermint breeding.. When a drop of the reagent (1 vol. concentrated nitric acid + 200 vol. glacial acetic acid) is added to a drop of peppermint oil, the mentho-furan present gives a blue coloration. This reaction can be used to determine the peppermint-oil content o...

Shpigel M.; Fishelson L., 1991: Experimental removal of piscivorous groupers of the genus cephalopholis serranidae from coral habitats in the gulf of aqaba red sea. Elimination of adult groupers (Cephalopholis spp.) from various reef formations in the Gulf of Aqaba (Red Sea) resulted in replenishment by other predatory fishes of different taxa and only partly (21.6%) by species of the same genus. Three years...

Basurmanova, O.K., 1964: Distinctive Features Of Fine Structure Of The Conducting Elements Of Cerebral Ganglion In Insects. Federation Proceedings. Translation Supplement; Selected Translations From Medical-Related Science 23: 1177-1180

Terenzi, H.F.; Roselino, E.; Passeron, S., 1971: Two types of pyruvate kinase in Mucor rouxii. Changes in the enzymatic pattern related to aerobic development. European Journal of Biochemistry 18(3): 342-350

Hou, M.F.; Huang, T.J.; Liu, G.C., 2001: The diagnostic value of galactography in patients with nipple discharge. To evaluate preoperative galactographic findings in the differentiation between the benign and malignant lesions in patients presenting spontaneous nipple discharge without mass. Of the 215 patients who have undergone the galactography, 181 cases...

Grimoldi, R.J.; Marquez, A.G., 1978: Liver and muscle enzymes in the blood of horses. Glutamic oxalacetic transaminase, alkaline phosphatase, lactate dehydrogenase, leucine aminopeptidase, aldolase and gamma glutamyl transpeptidase activities were estimated in 28 normal Thoroughbred crosses, and the mean values are tabulated. Clini...

Chameides, W.L., 2011: EPA in the crosshairs. Science 332(6028): 397-397

Fejkiel, W.; Sowa, J.; Szczudrawa, J., 1974: Correlation between laparotomy and histological studies in liver diseases. Polskie Archiwum Medycyny Wewnetrznej 51(7): 353-358