+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Gene Polymorphisms of Toll-Like Receptor 9 -1486T/C and 2848G/A in Cervical Cancer Risk

, : Gene Polymorphisms of Toll-Like Receptor 9 -1486T/C and 2848G/A in Cervical Cancer Risk. International Journal of Gynecological Cancer 25(7): 1173-1178

This work aims to explore whether Toll-like receptor 9 (TLR9) -1486T/C and 2848G/A polymorphisms are associated with cervical cancer risk. A comprehensive electronic search of studies published from January 1999 to October 2014 was conducted in Medline (Ovid), Embase, PubMed, Wanfang, Weipu, and CNKI. The algorithm included "TLR," "Toll-like receptor," "polymorphism," "variant," "mutation," and "cervical cancer." Seven articles, including 9 studies, were pooled using Revman 5.2 (Cochrane Collaboration, Copenhagen, Denmark). Odds ratio (OR) was used to explore the involvement of minor allele C (C vs T and CC + CT vs TT) of TLR9 (-1486T/C, rs187084) and minor allele A (A vs G and AA + AG vs GG) of TLR9 (2848G/A, rs352140) in cervical cancer risk. Toll-like receptor 9 (-1486T/C, rs187084) polymorphisms were associated with an elevated risk of cervical cancer (C vs T: OR, 1.15; 95% confidence interval [CI], 1.03-1.29; CC + CT vs TT: OR, 1.30; 95% CI, 1.11-1.53). We found no significant association between TLR9 (2848G/A, rs352140) polymorphisms and cervical cancer risk (A vs G: OR, 1.15; 95% CI, 0.87-1.54; AA + AG vs GG: OR, 1.27; 95% CI, 0.75-2.17). This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.


PMID: 26270118

DOI: 10.1097/IGC.0000000000000494

Other references

Hájek, M., 2005: Why I am a member of the Czech Medical Association J. Ev. Purkynĕ. Casopis Lekaru Ceskych 144(11): 719-720

Gaikwad, N.W.; Bodell, W.J., 2001: Formation of DNA adducts by microsomal and peroxidase activation of p-cresol: Role of quinone methide in DNA adduct formation. We have investigated the activation of p-cresol to form DNA adducts using horseradish peroxidase, rat liver microsomes and MnO(2). In vitro activation of p-cresol with horseradish peroxidase produced six DNA adducts with a relative adduct level of...

Proschek, D.; Kafchitsas, K.; Rauschmann, M.; Kurth, A.; Vogl, T.; Geiger, F., 2010: Reduction of radiation dose during radiofrequency denervation of the lumbar facet joints using the new targeting system SabreSource: a prospective study in 20 patients. Facet joint denervation is a frequently performed technique to treat facet joint syndrome. Most often this technique is used under fluoroscopic guidance implicating high radiation doses for both patients and surgeons. This prospective study was pe...

Kaplan, B.S.; Osokina, L.I.; Kostrova, A.A.; Ugaĭ, B.B.; Kaukhova, O.Ia., 1983: Cytochemical study of peripheral blood cells in psoriasis. Laboratornoe Delo: 6-8

Navis, G.J.; de Jong, P.E.; Donker, A.J.; de Zeeuw, D., 1983: Effects of enalapril on blood pressure and renal haemodynamics in essential hypertension. The effects of enalapril were assessed in a double-blind study versus propranolol. Twenty-two patients with essential hypertension were titrated with either enalapril (5, 10 and 20 mg twice daily) or propranolol (40, 80 and 120 mg twice daily). Wi...

Ketten, Darlene R., 1997: Structure and function in whale ears. Ultrasonic echolocation abilities are well documented in several dolphin species, but hearing characteristics are unknown for most whales. Vocalization data suggest whale hearing spans infra- to ultrasonic ranges. This paper presents an overview o...

Bruggemann, J.E.bersdobler, H., 1970: New data on the problem of protein damage due to heat treatment. Kraftfutter 53 (4) 172

Binder, C.; Lang, W., 1993: Necrotizing hepatitis with a fatal outcome after carbimazole therapy. A 74-year-old woman developed weakness, lack of appetite and abdominal swelling 7 months after starting treatment with carbimazole (10 mg/d for 10 weeks) and, subsequently, radioiodine for hyperthyroidism. Physical examination revealed generalized...

Paksarian, D.; Cui, L.; Angst, J.; Ajdacic-Gross, V.; Rössler, W.; Merikangas, K.R., 2017: Stability and change in reported age of onset of depression, back pain, and smoking over 29 years in a prospective cohort study. Accurate age of onset (AOO) measurement is vital to etiologic and preventive research. While AOO reports are known to be subject to recall error, few population-based studies have been used to investigate agreement in AOO reports over more than a...

Adair, A.; Parker, J.; Coombes,, 2003: Chronic myelomonocytic leukaemia presenting as a thyroid mass. British Journal of Haematology 120(4): 548, February