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Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism

, : Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism. Current Opinion in Lipidology 27(3): 257-263

Glucagon-like peptide-1 (GLP-1) is the best known incretin hormone able to potentiate glucose-induced insulin secretion. Moreover, GLP-1 is currently under intensive investigation as a potential crucial mediator of beneficial metabolic effects after bariatric surgery, because of its eating inhibitory, antiobesity, and antidiabetes effects. This review briefly summarizes recent findings on the specific effects of GLP-1 on lipoprotein metabolism. The related hormone GLP-2 is derived from the same precursor gene; its effects on lipoprotein metabolism will also be discussed briefly. Pharmacological activation of the GLP-1 system has beneficial effects on obesity-induced alterations of lipoprotein metabolism. These benefits can be observed with direct GLP-1 receptor agonists like liraglutide or exendin-4, but also with inhibitors of dipeptidyl peptidase IV (DPP-IV), which reduce the breakdown of endogenous GLP-1. The role of GLP-2-related pathways on lipid levels and metabolism are less clear, but some effects (e.g. increased intestinal chylomicron output) are opposite to GLP-1. Activation of the GLP-1-dependent pathways may perhaps translate into a lower cardiovascular risk. Understanding how GLP-1 and GLP-2 regulate and interact in the control of lipoprotein metabolism will set the stage for the development of new strategies to treat dyslipidaemia in obesity, diabetes, and other cardiometabolic diseases.


PMID: 27031273

DOI: 10.1097/MOL.0000000000000293

Other references

Dietrich, U.; Campos-Ortega, J.A., 1980: The effect of temperature on shibre t s cell clones in the compound eye of drosophila melanogaster. The effect of temperature on both developing and adult eye cell clones homozygous for shiST139, a temperature-sensitive mutant of D. melanogaster, was analyzed. The mutant gene, autonomous in its cellular expression, causes structural modification...

Serra, P., 1966: Tecniche immunologiche e diagnosi biologica dell'idatidosi. Atti Societa Peloritana di Scienze Fisiche Matematiche e Naturali, 12: 81-104

Grisdale, D.G., 1975: Simplified rearing of the eastern hemlock looper. A modified version of an artifical diet described by R.L. Burton that was less viscous and could be handled with the aid of an automatic dispenser [cf. 63, 1591] was used for the mass-rearing of Lambdina fiscellaria fiscellaria (Gn.). Methods are...

Webb S.D.; Newsom L., 1991: Diet of mammut americanum in late pleistocene of florida usa. Journal of Vertebrate Paleontology 11(SUPPL 3): 60A-61A

Botosaneanu, L., 1991: Amsterdam expeditions to the west indian islands report 71. trichoptera from haiti. Results of sporadically sampling of caddis flies during a stygobiological expedition to Haiti [West Indies] in 1979. A total of 28 species are recorded; 12 species belonging to the genera Atopsyche BANKS, Alisotrichia FLINT, Ochrotrichia MOSELY, O...

Feys Robert, 1964: The palaeopedology of coal basins. The character of seat earths and of various layers representing products of soilforming processes in barren measures associated with coal-bearing sequences refutes the concept that coal measures were formed under uniform humid tropical climatic co...

Jakoubek, B., 1983: Endorphins and enkephalins in the central nervous system. Their receptors and functional anatomy. Ceskoslovenska Fysiologie 32(2): 99-121

Bills, S.S., 1986: Advantages, opportunities many as patient education moves to outpatient setting. Promoting Health 7(2): 6-8

Jabbour S.; Apstein C.S.; Hueter D.; Ryan T.J.; Hood W.B.Jr, 1977: Noninvasive indices of aortic stenosis in patients with left ventricular failure. Clinical Research 25(3): 228A

Lazebnik, L.B.; Khomeriki, S.G.; Il'chenko, L.Iu.; Rumiantsev, V.G., 2004: Ways of reducing oncological morbidity in gastroenterology and mortality from cancer of the digestive organs. Eksperimental'naia i Klinicheskaia Gastroenterologiia 6): 134-141