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Glycididazole sodium combined with radioiodine therapy for patients with differentiated thyroid carcinoma (DTC)

, : Glycididazole sodium combined with radioiodine therapy for patients with differentiated thyroid carcinoma (DTC). International Journal of Clinical and Experimental Medicine 8(8): 14095-9

The aim of the present study was to evaluate efficacy and side effects of glycididazole sodium (CMNa) combined with radioiodine therapy for patients with DTC cervical metastases. 53 patients of DTC cervical lymph node metastasis were randomly divided into 2 groups, where 24 cases were treated with 4.44 GBq of (131)I alone, 29 cases were treated with 800 mg/m(2) of CMNa combined with 4.44 GBq of (131)I. Peripheral blood samples were collected before and after treatment to perform measurements of routine blood test, liver function, renal function, parathyroid hormone (PTH), lymphocyte micronucleus rates and chromosome mutation. The results showed that rates of complete response (CR) in CMNa combined with radioiodine group (65.5%) were significantly higher than that in radioiodine monotherapy group (37.5%). Furthermore, CMNa combined with adioiodine treatment significantly increased the percentage of thyroglobulin (Tg) reduction at 12 weeks after treatment (P<0.05). There is no significant difference in blood routine, liver function, renal function, PTH, lymphocyte micronucleus rates and chromosome mutation rates before and 12 weeks after treatment (P>0.05). These results indicate 4.44 GBq of (131)I treatment combined with 800 mg/m(2) of CMNa could significantly improve clinical efficacy of DTC patients without increasing side effects.


PMID: 26550375

Other references

Liebreich, R., 1871: Clinical Lectures on Ophthalmology. British Medical Journal 2(570): 633-633

Bures, J.; Malir, F.; Sobotka, L.; Jergeova, Z.; Zadak, Z.; Horacek, J.; Cervenka, B.; Komarkova, O., 1990: Urinary phenol in Crohn's disease during total parenteral nutrition. Urinary phenol was studied in Crohn's disease before and after 2 weeks of total parenteral nutrition in 10 patients 24 to 40 years old. Each patient received twice a week a solution providing amino acids 1.45 g/kg, energy 105 to 125 kJ/kg and...

Renzulli, A.; Vitale, N.; D'Onofrio, A.; Cotrufo, M., 1994: Implantable cardioverter defibrillator malfunction due to transvenous lead insulation break. Pacing and Clinical Electrophysiology 17(2): 245-246

Dubey, S.C.; Sharma, S.N., 1985: Ovine adenovirus (OAV) pneumoenteritis in lambs in India. Two strains of ovine adenovirus type 1 were isolated from nasal or rectal swabs of young lambs with pneumonia and enteritis. This appears to be the first report of this virus in India.

Fiorillo Francesco, 2004: Blue clay slope angle in relation to some geological and geotechnical characteristics, Italy. Observation of blue clay slopes outcropping along the Italian peninsula (Apennine foredeep and other inland areas) prompted investigation into several factors which govern their actual slope angle. Though characterized by good gradient, slope angl...

Konno N.; Fujimaki H., 1996: The Sr isotopic composition of paleocean recorded in fossil fish teeth. International Geological Congress, Abstracts = Congres Geologique International, Resumes 30, Vol

Kularatne, S.A.M.; Pathirage, M.M.K.; Kumarasiri, P.V.R.; Gunasena, S.; Mahindawanse, S.I., 2007: Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005. A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. S...

Schiweck, H., 1977: Chemistry and technology of disaccharide alcohols and L-sorbose. Deutsche Zahnarztliche Zeitschrift 32(5 Suppl 1): S12-S18

Halpern, M.J.; Mesquita, F.; Campos, E.M.; McConathy, W.J., 1987: Latent type IV. Advances in Experimental Medicine and Biology 210: 213-218

Chandra P., 1989: Use of penicillamine for treating immune damaging illnesses us patent 4847297 july 11 1989. Official Gazette of the United States Patent & Trademark Office Patents 1104(2): 1257