+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Harlequin syndrome: a mask of rare dysautonomic syndromes

, : Harlequin syndrome: a mask of rare dysautonomic syndromes. Dermatology Online Journal 21(4): -

Harlequin syndrome (HS) is a rare disorder of the sympathetic nervous system which presents with unilateral decreased sweating and flushing of the face, neck, and chest in response to heat, exercise, or emotional factors. The contralateral side displays a compensatory overreaction to provide normal heat regulation of the face as a whole. In the literature, most of the cases are primary in nature and no underlying cause could be identified. Harlequin sign is used to denote these symptoms in patients who also exhibit associated oculosympathetic paresis, such as Horner syndrome, Adie syndrome, and Ross syndrome.We report a rare case of a 13-year-old boy who presented with complaints of flushing and sweating of the left side of the face after exertion, while the right side remained dry and maintained its normal color. No structural abnormality was identified on detailed work up. Thus, diagnosis of classic idiopathic HS was made. Despite the rarity of this syndrome, dermatologists should be acquainted with this distinctive entity and should refer the patient for complete ophthalmological and neurological examination.


PMID: 25933078

Other references

Schmidt, A., 1929: Methyl alcohol poisoning in Rumania. Zeitschr Untersuch Lebensmitteln 57(6): 584-587

Yin, S.; Zhang, C.; Jin, D.; Chen, S.; Sun, Y.; Sheng, J., 2011: Treatment of osteonecrosis of the femoral head in lymphoma patients by free vascularised fibular grafting. The purpose of this study was to assess the outcomes of treatment of femoral head osteonecrosis using free vascularised fibular grafting in patients with Hodgkin's disease and non-Hodgkin's lymphoma. We retrospectively reviewed seven pat...

Chesworth Ward, 1972: The stability of gibbsite and boehmite at the surface of the Earth. Literature review, experimental studies, stability in soils.

Rolston, D.D.K.; Rolston, R.K.; Shin, K.; Blochin, B.; Cabungal, C.; Anbar, R.; Holsclaw, D.S.; Kreuger, L.J.; Lebenthal, E., 1993: Secretin, a gut hormone, might be modulating chloride transport in normal bronchial epithelial cells. Pediatric Research 33(4 PART 2): 385A

Adler, F.H., 1951: Diagnostic value of transillumination of the eyeball. American Journal of Ophthalmology 34(6): 902-902

Harnden, A.; Shakespeare, J., 2001: 10-minute consultation: MMR immunisation. Bmj 323(7303): 32-32

Hendrix S.D.; Trapp E.J., 1981: Plant herbivore interactions insect induced changes in host plant sex expression and fecundity. Changes were investigated in the reproduction of Pastinaca sativa which result in compensatory reproduction when herbivore [Depressaria pastinacella (Duponchel)] feeding destroys the 1st inflorescence produced. Late developing inflorescences of da...

Kawabe, Momoki., 2006: Factors of interspecific pair formation between Japanese wagtail, Motacilla grandis and white wagtail, M. alba lugens. The male Motacilla grandis and the female M. alba became a pair at the Oribe river in the central Hokkaido, 1976. This interspecific pair nested under the driftwood on the dry river bed and laid four eggs. Only one out of the four eggs hatched on...

Shek, D.T.L.; Ma, H.Keung., 2007: Subjective outcome evaluation of the project P.A.T.H.S.: findings based on the perspective of the program participants. A total of 52 schools (n = 8679 students) participated in the experimental implementation phase of the project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes). After completion of the Tier 1 Program, students were inv...

Berson, S.A.; Yallow, R.S., 1961: Immunochemical distinction between insulins with identical amino-acid sequences. Nature 191: 1392-1393