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Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA

, : Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA. American Journal of Psychiatry (): Appiajp201616030336-Appiajp201616030336

Insomnia is associated with increased risk for suicide. The Food and Drug Administration (FDA) has mandated that warnings regarding suicide be included in the prescribing information for hypnotic medications. The authors conducted a review of the evidence for and against the claim that hypnotics increase the risk of suicide. This review focused on modern, FDA-approved hypnotics, beginning with the introduction of benzodiazepines, limiting its findings to adults. PubMed and Web of Science were searched, crossing the terms "suicide" and "suicidal" with each of the modern FDA-approved hypnotics. The FDA web site was searched for postmarketing safety reviews, and the FDA was contacted with requests to provide detailed case reports for hypnotic-related suicide deaths reported through its Adverse Event Reporting System. Epidemiological studies show that hypnotics are associated with an increased risk for suicide. However, none of these studies adequately controlled for depression or other psychiatric disorders that may be linked with insomnia. Suicide deaths have been reported from single-agent hypnotic overdoses. A separate concern is that benzodiazepine receptor agonist hypnotics can cause parasomnias, which in rare cases may lead to suicidal ideation or suicidal behavior in persons who were not known to be suicidal. On the other hand, ongoing research is testing whether treatment of insomnia may reduce suicidality in adults with depression. The review findings indicate that hypnotic medications are associated with suicidal ideation. Future studies should be designed to assess whether increases in suicidality result from CNS impairments from a given hypnotic medication or whether such medication decreases suicidality because of improvements in insomnia.


PMID: 27609243

DOI: 10.1176/appi.ajp.2016.16030336

Other references

Noureldin, M.S.; El-Naggar, H.M.; El-Shinnawy, H.; Abou Elenin, A.; E.S.erif, E.A., 2003: Quantitative inhibition ELISA for diagnosis of schistosomiasis using human IgG labeled with fluorescein and anti-fluorescein/peroxidase. Usually mouse monoclonal antibodies are used in inhibition assays for antibody determination. Interference may occur in these inhibition assays due to presence of naturally occurring anti-mouse antibodies in some human serum samples. To avoid such...

Roubal, J., 1931: Eine weitere nova Oxypoda aus der Slovakei. Acta Societatis Entomologicae Cechoslovenicae, 28: 0-71

Semitcheva, T.; Yorelishev, S.K.; Vitebskaia, A.V.; Peterkova, V.A., 1999: Frequency of CNS tumors in children with true precocious puberty. Hormone Research (Basel) 51(SUPPL 2): 69, Aug

Khlystov, V.N.; Shinkarev, N.V., 1980: Modification to the operating table for thoracic surgery. Klinicheskaia Khirurgiia: 63-64

Il'ina N.A.; Khokhlov A.P.; Polyakova N.F.; Antipova R.I., 1980: Use of adenylate cyclase inhibitors in the treatment of myopathies. The effect of the Soviet drug anapriline, a blocker of .beta.-adrenoreceptors which decreased cAMP content in muscular tissues, on various myopathies was studied. Dystrophic changes in Duchenne's and Becker's myopathies were caused by a...

Allgayer, B.; Reiser, M.; Feuerbach, S., 1984: CT diagnosis of phlebothrombosis in Baker's cyst. Rofo 141(5): 593-594

Braun, C.M.J., 2007: Evolution of hemispheric specialisation of antagonistic systems of management of the body's energy resources. Excellent and rich reviews of lateralised behaviour in animals have recently been published indexing renewed interest in biological theorising about hemispheric specialisation and yielding rich theory. The present review proposes a new account of...

Eser, D.; Adak, M.S.; Biesantz, A., 1999: Effect of fallow, winter lentils, nitrogen fertilizer and different tillage methods on wheat yield in the dry farming areas of Central Anatolia. Results of 2 crop rotation cycles in field trials in Haymana and Gozlu, Turkey, showed that in Haymana there were no significant differences in wheat yields after fallow or lentils, while sowing of winter lentils was more profitable. In Gozlu, whe...

Ho, T.D.; Valance, A.; Dupont, P.; Ould E.M.ctar, A., 2011: Scaling laws in aeolian sand transport. We report on wind tunnel measurements on saltating particles in a turbulent boundary layer and provide evidence that over an erodible bed the particle velocity in the saltation layer and the saltation length are almost invariant with the wind stre...

Bydder, G.M.; Rutherford, M.A.; Hajnal, J.V., 2001: How to perform diffusion-weighted imaging. Diffusion-weighted imaging (DWI) has become an invaluable tool in the management of patients with stroke. DWI relies on detecting the random diffusion of water molecules. In normal tissues this movement may be restricted by the presence of cellula...