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IRAK1 variant is protective for orthodontic-induced external apical root resorption

, : IRAK1 variant is protective for orthodontic-induced external apical root resorption. Oral Diseases 22(7): 658-664

Interleukin-1 beta (IL1B) pathway is a key player in orthodontic-induced external apical root resorption (EARR). The aim of this work was to identify the genes related to the IL1 pathway as possible candidate genes for EARR, which might be included in an integrative predictive model of this complex phenotype. Using a stepwise multiple linear regression model, 195 patients who had undergone orthodontic treatment were assessed for clinical and genetic factors associated with %EARRmax (maximum %EARR value obtained for each patient). The four maxillary incisors and the two maxillary canines were assessed. Three functional single nucleotide polymorphisms (SNPs) were genotyped: rs1143634 in IL1B gene, rs315952 in IL1RN gene, and rs1059703 in X-linked IRAK1 gene. The model showed that four of the nine clinical variables and one SNP explained 30% of the %EARRmax variability. The most significant unique contributions to the model were gender (P = 0.001), treatment duration (P < 0.001), premolar extractions (P = 0.003), Hyrax appliance (P < 0.001), and homozygosity/hemizygosity for variant C from IRAK1 gene (P = 0.018), which proved to be a protective factor. IRAK1 polymorphism is proposed as a protective variant for EARR.


PMID: 27250598

DOI: 10.1111/odi.12514

Other references

Tarhan, S.; Moffitt, E.A.; Taylor, W.F.; Giuliani, E.R., 1977: Myocardial infarction after general anesthesia. During 1967 and 1968, a total of 32,877 patients had general anesthesia at the Mayo Clinic; 422 had previous myocardial infarction. Of these 6.6% experienced another infarction during the first postoperative week. There was no relationship between...

Sell, D.R.; Rogler, J.C.; Featherston, W.R., 1983: The effects of sorghum tannin and protein level on the performance of laying hens maintained in two temperature environments. A total of 144 White Leghorn hens were separated into 8 groups, according to egg yield during 10 days, and fed on isonitrogenous diets low or high in tannin sorghum grains and containing 11.5 or 14.5% protein from sorghum and soya bean meal. Each...

Skokov J., 1979: Ceramic materials in the western part of the Cheb Basin. Geologicky Pruzkum 21(6): 161-164

Mozrzymas, A., 2013: Modelling of the Critical Micelle Concentration of Cationic Gemini Surfactants Using Molecular Connectivity Indices. Modelling of the critical micelle concentrations (<i>cmc</i>) using the molecular connectivity indices was performed for a set of 21 cationic gemini surfactants with medium-length spacers. The obtained model contains only the second-or...

Sajda, P.; Du, S.; Brown, T.R.; Stoyanova, R.; Shungu, D.C.; Mao, X.; Parra, L.C., 2004: Nonnegative matrix factorization for rapid recovery of constituent spectra in magnetic resonance chemical shift imaging of the brain. We present an algorithm for blindly recovering constituent source spectra from magnetic resonance (MR) chemical shift imaging (CSI) of the human brain. The algorithm, which we call constrained nonnegative matrix factorization (cNMF), does not enfo...

Shaheen M.A.; Hammouda M.A., 1982: Heritability estimates phenotypic and genotypic variation in some citrus citrus spp rootstocks and scions. Hortscience 17(3 SECT 2): 494

Aiache, J.M.; Mandon, P.; Charbonne, F.; Febvre, P., 1972: Study of the stability of a lipase of fungal origin as a function of vehicles and preservation conditions. Journal de Pharmacie de Belgique 26(3): 346-354

Moy, P.; Lobb, R.; Tizard, R.; Olson, D.; Hession, C., 1993: Cloning of an inflammation-specific phosphatidyl inositol-linked form of murine vascular cell adhesion molecule-1. Vascular cell adhesion molecule-1 (VCAM1) is a member of the immunoglobulin (Ig) superfamily which interacts with the integrin very late antigen-4 (VLA4). The VCAM1/VLA4 interaction mediates both adhesion and signal transduction and is thought to...

Kim, Y.; Kim, S.; Kim, S.; Cho, K., 1999: Enhanced response to endothelin-1 in the obstructed renal pelvis of rabbits. Journal of Urology 161(4 SUPPL ): 85, April

Prakash Hande, M.; Ume Devi, P.; Jagetia, G.C., 1990: Effect of "in utero" exposure to low doses of low energy X-rays on the postnatal development of mouse. Pregnant Swiss albino mice were exposed to a single dose of 9 mGy or 50 mGy of 70 kVp X-rays on day 3.5 (preimplantation), 6.5 (early organogenesis) or 11.5 (late organogenesis) of gestation. The offspring were observed for any radiation induced c...