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Immediate Transoral Allogeneic Bone Grafting for Large Mandibular Defects. Less Morbidity, More Bone. A Paradigm in Benign Tumor Mandibular Reconstruction?

, : Immediate Transoral Allogeneic Bone Grafting for Large Mandibular Defects. Less Morbidity, More Bone. A Paradigm in Benign Tumor Mandibular Reconstruction?. Journal of Oral and Maxillofacial Surgery

Reconstruction of hard tissue continuity defects caused by ablative tumor surgery has been traditionally reconstructed with autogenous bone grafts or microvascular free flaps. Although results have been predictable from these 2 methods of reconstruction, the morbidity associated with bone harvest is quite serious for the patient. Predictable results have been obtained with using a combination of 100% cadaver bone, bone marrow aspirate concentrate (BMAC), and recombinant human bone morphogenic protein in immediate reconstruction for benign tumor extirpations through the extraoral approach. In light of these successful outcomes, the same combination was evaluated with an intraoral approach. This study evaluated the success of immediate mandibular reconstruction through the intraoral approach without any autogenous bone harvesting. The aim of this retrospective study was to share the authors' experience with the use of 100% allogeneic bone in combination with bone morphogenic protein and BMAC through the transoral approach for immediate reconstruction of continuity defects that resulted from benign tumor surgery. A retrospective chart review was performed of all patients undergoing bone graft reconstruction at the University of Texas Health Sciences Center at Houston (UTHealth) Department of Oral and Maxillofacial Surgery from December 2014 through January 2016. Inclusion criteria were biopsy-proven benign tumors, American Society of Anesthesiologists I or II health status, and adequate intraoral soft tissue for primary closure determined during initial consultation. Five patients who underwent this procedure at the UTHealth Department of Oral and Maxillofacial Surgery from December 2014 through January 2016 are presented. The success rate was 100%. All patients showed excellent bone quality clinically and radiographically for endosseous dental implant placement. With the transoral approach and no autogenous bone harvesting, the average operating time was 3.4 hours and the hospital stay was 2.4 days. Composite allogeneic tissue engineering is an effective and predictable technique for immediate reconstruction of continuity defects from ablative benign tumor surgery. Overall, there was no donor site morbidity, the intraoperative time was shorter, there were fewer admission days, and total costs overall were lower compared with traditional methods.


PMID: 27810548

DOI: 10.1016/j.joms.2016.09.049

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Belich A.I.; Karmanova I.G.; Shilling N.V., 1982: Motor phenomena at the background of the primary and intermediate sleep in poikilothermic vertebrates. Against the background of the primary (fishes, amphibians) and intermediate (reptiles) sleep of vertebrates motor phenomena were observed which precede either the deepening of sleep or the increase in the level of awakefulness. These phenomena pro...

Steinhart, J.S.; Steinhart, C.E., 1974: Energy use in the U.S. food system. This interesting and topical article investigates energy use in the US food system. On the farm total energy used (1012 kcal) in 1940, 1950, 1960 and 1970 was respectively 124.5, 303.4, 373.9 and 526.1; in the processing industry totals were 285.8...

D.Barbieri, A., 1967: Pharmacologic properties of the 1(p-hydroxyphenyl)2-phenyl-3-hydroxy-4-n-butyl-5-pyrazolinonate of 2-beta-hydroxyphenethylamino-pyridine and research on its biochemical action. Minerva Medica 58(32): 1415-1417

Wang, Y-qi.; Yang, B.; Zhang, R-song.; Wei, E-qing., 2011: Inhibitive effect of C-21 steroidal glycosides of Cynanchum auriculatum on rat glioma cells in vitro. To evaluate the inhibitive effect of C-21 steroidal glycosides from the root of Cynanchum auriculatum (CGB) on rat glioma C6 cells. C6 cells were treated with CGB for 24, 48,72 h at concentration of 30, 60, 120 mg/L, respectively. MTT assay was us...

Baumann, S., 1984: Fast food on the move. Some franchise restaurauteurs are building sales by taking their operations to the customers. The operators featured are: a co-owner of nine Shakey's Pizza units who runs two seasonal operations in permanent buildings; a burger King franchise...

Thomas, RC., 1980: Regulation of intracellular Na+, K+, and H+ concentrations in snail neurons. Cold Spring Harbor Reports In The Neurosciences: 1: 65-72

Short, M.B.; Middleman, A.B., 2015: Focusing on flu: adolescents' perspectives on school-located immunization programs for influenza vaccine. To describe adolescents' perspectives regarding the use of school-located immunization programs (SLIP) for influenza vaccination. More importantly, adolescents were asked what factors would make them more or less likely to use a SLIP offering...

Spektor, D.Ia., 1968: On the determination of neutral 17-ketosteroids in the urine by the Uvarovskaia method. Laboratornoe Delo 2: 111-111

Intra, M.; Gentilini, O.; Brenelli, F.; Chagas, E.Malaquias.; Veronesi, U.; Sandri, M.Teresa., 2005: Breast cancer among HIV-infected patients: the experience of the European Institute of Oncology. Journal of Surgical Oncology 91(2): 141-142

Ma, X.; Labinaz, M.; Goldstein, J.; Miller, H.; Keon, W.J.; Letarte, M.; O'Brien, E., 2000: Endoglin is overexpressed after arterial injury and is required for transforming growth factor-beta-induced inhibition of smooth muscle cell migration. Endoglin is a homodimeric membrane glycoprotein primarily expressed on endothelial cells. In association with transforming growth factor (TGF)-beta receptors I and II, it can bind TGF-beta1 and -beta3 and form a functional receptor complex. There...