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Impact of a Daily SMS Medication Reminder System on Tuberculosis Treatment Outcomes: A Randomized Controlled Trial


, : Impact of a Daily SMS Medication Reminder System on Tuberculosis Treatment Outcomes: A Randomized Controlled Trial. Plos One 11(11): E0162944-E0162944

The rapid uptake of mobile phones in low and middle-income countries over the past decade has provided public health programs unprecedented access to patients. While programs have used text messages to improve medication adherence, there have been no high-powered trials evaluating their impact on tuberculosis treatment outcomes. To measure the impact of Zindagi SMS, a two-way SMS reminder system, on treatment success of people with drug-sensitive tuberculosis. We conducted a two-arm, parallel design, effectiveness randomized controlled trial in Karachi, Pakistan. Individual participants were randomized to either Zindagi SMS or the control group. Zindagi SMS sent daily SMS reminders to participants and asked them to respond through SMS or missed (unbilled) calls after taking their medication. Non-respondents were sent up to three reminders a day. Public and private sector tuberculosis clinics in Karachi, Pakistan. Newly-diagnosed patients with smear or bacteriologically positive pulmonary tuberculosis who were on treatment for less than two weeks; 15 years of age or older; reported having access to a mobile phone; and intended to live in Karachi throughout treatment were eligible to participate. We enrolled 2,207 participants, with 1,110 randomized to Zindagi SMS and 1,097 to the control group. The primary outcome was clinically recorded treatment success based upon intention-to-treat. We found no significant difference between the Zindagi SMS or control groups for treatment success (719 or 83% vs. 903 or 83%, respectively, p = 0·782). There was no significant program effect on self-reported medication adherence reported during unannounced visits during treatment. In this large-scale randomized controlled effectiveness trial of SMS medication reminders for tuberculosis treatment, we found no significant impact. The trial was registered with ClinicalTrials.gov, NCT01690754.

US$19.90

PMID: 27802283

DOI: 10.1371/journal.pone.0162944


Other references

Brodbeck, B.V.; Andersen, P.C.; Oden, S.; Mizell, R.F.; McKamey, S.H.; Zapata, M., 2017: The Distribution of Cicadellinae Leafhoppers and Other Auchenorrhyncha on Coffee and Citrus in Puerto Rico. Label="Key words">: Caribovia coffeacola, Cicadellinae, coffee, Xylella fastidiosa.

Miyakawa, Y.; Tanigaki, N.; Kreiter, V.P.; Moore, G.E.; Pressman, D., 1973: Characterization of soluble substances in plasma carrying HL-A alloantigenic activity and HL-A common antigenic activity. Transplantation 15(3): 312-319

Hussain, J.; Laufer, N.; Sorrof, S.; Pershad, A., 2010: Takotsubo cardiomyopathy after coronary intervention developed during hospitalization. Stress-induced cardiomyopathy is an increasingly recognized syndrome characterized by transient apical or midventricular dysfunction that mimics myocardial infarction in the absence of significant coronary artery disease. We describe a case of tak...

Jürgenssen, O.A.; Jellinger, K.; Lachmann, D., 1975: Oculocerebrovertebral syndrome. After description of the oculovertebral syndrome Weyers-Thier a personal observation is reported. It was characterized by severe cerebral malformations (agenesis of the olfactory lobes, incomplete agenesis of corpus callosum with large sagittal ar...

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Krupp, K.; Mccamish, M.; Ross, J.; Mcmanaway, C.; Hodges, S.P.terson And J., 1993: The effect of automatic flushing on nasogastric tube clogging rates. Journal of the American College of Nutrition 12(5): 598

Webster, C.; Paracelsus, 1982: Paracelsus and Paracelsianism: basic data. Society for the Social History of Medicine Bulletin: 47-50

Nau, J-Yves., 2012: Serotonin, discovered 60 years ago. Revue Medicale Suisse 8(347): 1428-1429

Nilsson, C.; Edwards, K.; Eriksson, J.; Larsen, S.Weng.; Østergaard, J.; Larsen, C.; Urtti, A.; Yaghmur, A., 2012: Characterization of oil-free and oil-loaded liquid-crystalline particles stabilized by negatively charged stabilizer citrem. The present study was designed to evaluate the effect of the negatively charged food-grade emulsifier citrem on the internal nanostructures of oil-free and oil-loaded aqueous dispersions of phytantriol (PHYT) and glyceryl monooleate (GMO). To our...

Hayashi, E.; Terada, M.; Takamura, S., 1968: The influence of oxygen pressure on the survival time of Ascaris lumbricoides var. suum. The influence of oxygen tension on the survival of pig Ascaris in vitro in both liquid and gaseous media was investigated. In Tyrode's solution at 37 degrees C. 50% of worms survived for 19 days with 20% oxygen in the atmosphere and for 20 da...