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Impact of body mass on recurrence and progression in Chinese patients with Ta, T1 urothelial bladder cancer


, : Impact of body mass on recurrence and progression in Chinese patients with Ta, T1 urothelial bladder cancer. International Urology and Nephrology 47(7): 1135-1141

To evaluate the impact of body mass on recurrence and progression in patients with Ta, T1 urothelial bladder cancer. Data from 469 patients with Ta, T1 bladder cancer who were treated with transurethral resection of bladder tumor at our center during 2006-2014 were retrospectively studied. According to body mass index (BMI), patients were divided into three groups: normal weight (BMI < 24 kg/m(2)), overweight (24 kg/m(2) ≤ BMI < 28 kg/m(2)) and obesity (BMI ≥ 28 kg/m(2)). Clinicopathologic features were compared across groups. Kaplan-Meier curves and Cox proportional hazards regression analyses were employed to assess the association between body mass and oncologic outcomes. Compared with patients with normal weight, overweight and obese counterparts showed significantly shorter recurrence-free or progression-free survival. In multivariate analyses, being overweight was an independent factor for recurrence and obesity was for both recurrence and progression. The presence of diabetes mellitus (DM) was not a strong risk factor for the entire cohort, while it became a significant predictor for both recurrence and progression in the subgroup of overweight and obese patients. Excessive body mass seems to act as independent risk factors for worse oncologic outcomes of Ta, T1 bladder cancer. Further studies should be carried out to elucidate the exact impact of obesity, DM or even other metabolic disorders.

US$19.90

PMID: 26009259

DOI: 10.1007/s11255-015-1013-1


Other references

Nevins, M.; Kim, D.M., 2010: Classical versus contemporary treatment planning for aggressive periodontal disease. This case report presents a patient with a history of generalized aggressive periodontitis who has been maintained with the same periodontal prostheses for the past 40 years. A 39-year-old healthy woman extremely susceptible to inflammatory period...

Martinez, G.; Molina, X.; Olmedo, M.I.abel; Montecino, V., 2000: Susceptibility to ultraviolet B radiation of the dinoflagellate Alexandrium catenella Kofoid Balech, and the diatom Phaeodactylum tricornutum Bohlin. Differential susceptibility to ultraviolet B (UV-B, 280 - 320 nm) radiation among microalgae generates patterns of dominance in phytoplankton assemblages. However, despite some events of harmful algal blooms (HAB's) of the dinoflagellate Alex...

Combiesco, D., 1934: Weil-Felix Reaction in Dogs at Constantza. Constantza is at present the only place in Rumania where boutonneuse fever is met with, 34 cases in 1931, 3 or 4 in 1933. Many infected ticks were found in various parts of the town in 1932 but only one human case; the author considers that the vi...

Arnold G.H., 1988: Symposium on the contribution of biological nitrogen fixation to plant production cisarua indonesia august 3 7 1987. Plant & Soil 108(1): 1-199

Shulga, A.A.; Znamenskaya, L.V.; Morozova, O.V.; Leshchinskaya, I.B.; Kirpichnikov, M.P., 2000: Ribonuclease from Bacillus thuringiensis var. subtoxicus: Gene structure and regulation of biosynthesis. The gene for extracellular guanyl-specific ribonuclease of Bacillus thuringiensis var. subtoxicus (RNase Bth), a close homologue of the B. intermedius RNase (binase), was completely sequenced. Analysis of nucleotide sequences in the regions adjoin...

Shiyan S.D.; Nasonov V.V.; Markin V.A.; Belyanchikov I.M., 1988: Hplc of n 4 methylcoumarin 7 ylglycamines in structural studies of n linked glycoprotein carbohydrate chains. Using glycoproteins of known structure, an effective method of structural analysis of N-linked carbohydrate chains in glycoproteins is reported. It involves the oligosaccharide (OS) release by hydrazinolysis followed by re-N-acetylation, transform...

Harth, K.; Hibst, H.; Dembowski, J.; Spengler, R.; Flaig, E., 1997: Delayed-release form for pharmaceutical active compounds. Official Gazette of the United States Patent & Trademark Office Patents 1205(1): 373, Dec 2

Kaiser, Mark J., 2009: Gulf marginal production; 1, Reserves, revenues substantial in marginal Gulf of Mexico fields. Oil & Gas Journal 107.45

Ahmad S., 1991: Public attitude towards water and water reuse. Water Science & Technology 23(10-12): 2165-2170

Monadjemi, N., 1972: Study of brachypterism in Aphelinus asychis Wlk. (Hym. Aphelinidae). A brachypterous strain of Aphelinus asychis Wlk. (a parasite of various aphids) from France, in which the wings are not functional, was compared with a macropterous strain from Iran. Wing length was found to be closely correlated with the size of...