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Impact of body mass on recurrence and progression in Chinese patients with Ta, T1 urothelial bladder cancer

, : Impact of body mass on recurrence and progression in Chinese patients with Ta, T1 urothelial bladder cancer. International Urology and Nephrology 47(7): 1135-1141

To evaluate the impact of body mass on recurrence and progression in patients with Ta, T1 urothelial bladder cancer. Data from 469 patients with Ta, T1 bladder cancer who were treated with transurethral resection of bladder tumor at our center during 2006-2014 were retrospectively studied. According to body mass index (BMI), patients were divided into three groups: normal weight (BMI < 24 kg/m(2)), overweight (24 kg/m(2) ≤ BMI < 28 kg/m(2)) and obesity (BMI ≥ 28 kg/m(2)). Clinicopathologic features were compared across groups. Kaplan-Meier curves and Cox proportional hazards regression analyses were employed to assess the association between body mass and oncologic outcomes. Compared with patients with normal weight, overweight and obese counterparts showed significantly shorter recurrence-free or progression-free survival. In multivariate analyses, being overweight was an independent factor for recurrence and obesity was for both recurrence and progression. The presence of diabetes mellitus (DM) was not a strong risk factor for the entire cohort, while it became a significant predictor for both recurrence and progression in the subgroup of overweight and obese patients. Excessive body mass seems to act as independent risk factors for worse oncologic outcomes of Ta, T1 bladder cancer. Further studies should be carried out to elucidate the exact impact of obesity, DM or even other metabolic disorders.


PMID: 26009259

DOI: 10.1007/s11255-015-1013-1

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Nevins, M.; Kim, D.M., 2010: Classical versus contemporary treatment planning for aggressive periodontal disease. This case report presents a patient with a history of generalized aggressive periodontitis who has been maintained with the same periodontal prostheses for the past 40 years. A 39-year-old healthy woman extremely susceptible to inflammatory period...

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Combiesco, D., 1934: Weil-Felix Reaction in Dogs at Constantza. Constantza is at present the only place in Rumania where boutonneuse fever is met with, 34 cases in 1931, 3 or 4 in 1933. Many infected ticks were found in various parts of the town in 1932 but only one human case; the author considers that the vi...

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Harth, K.; Hibst, H.; Dembowski, J.; Spengler, R.; Flaig, E., 1997: Delayed-release form for pharmaceutical active compounds. Official Gazette of the United States Patent & Trademark Office Patents 1205(1): 373, Dec 2

Kaiser, Mark J., 2009: Gulf marginal production; 1, Reserves, revenues substantial in marginal Gulf of Mexico fields. Oil & Gas Journal 107.45

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Monadjemi, N., 1972: Study of brachypterism in Aphelinus asychis Wlk. (Hym. Aphelinidae). A brachypterous strain of Aphelinus asychis Wlk. (a parasite of various aphids) from France, in which the wings are not functional, was compared with a macropterous strain from Iran. Wing length was found to be closely correlated with the size of...