+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Improvement of meal-related symptoms and epigastric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan

, : Improvement of meal-related symptoms and epigastric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan. Neurogastroenterology and Motility 28(7): 1037-1047

The aim of this study is to clarify whether acotiamide and rabeprazole combination therapy can improve clinical symptoms, gastric emptying, and satisfaction with treatment in functional dyspepsia (FD) patients more effectively than acotiamide or rabeprazole monotherapy alone. We also aimed to determine whether acotiamide affects these changes via its effect on gastric emptying and appetite-related hormones such as ghrelin. We used Rome III criteria to evaluate upper abdominal symptoms and anxiety by the State-Trait Anxiety Inventory (STAI). Gastric motility was evaluated by the (13) C-acetate breath test. Eighty-one FD patients were treated with acotiamide (300 mg/day) (n = 35), acotiamide (300 mg/day) and rabeprazole (10 mg/day) (n = 28), or rabeprazole (10 mg/day) (n = 18) for a period of 4 weeks and followed after 4 weeks of no treatment. Adenocorticotropic hormone (ACTH), cortisol, leptin and ghrelin levels were measured in all FD patients. Acotiamide and rabeprazole combination therapy significantly improved postprandial distress syndrome (PDS)-like symptoms (p = 0.018, p = 0.04 and p = 0.041, respectively) and epigastric pain (p = 0.024) as wells as STAI-state scores (p = 0.04) compared to rabeprazole monotherapy. Both acotiamide monotherapy, and acotiamide taken in combination with rabeprazole, significantly (p = 0.001 and p = 0.02, respectively) improved satisfaction with treatment, compared to rabeprazole monotherapy. Acotiamide and rabeprazole combination therapy had no significant effect on ACTH and cortisol levels in FD patients. Of interest, acotiamide monotherapy, and acotiamide and rabeprazole combination therapy, significantly (p < 0.0001 and p = 0.018, respectively) increased acylated ghrelin/total ghrelin ratios and significantly (p = 0.04) improved impaired gastric emptying compared to rabeprazole monotherapy. Further studies are warranted to clarify how acotiamide treatment improves clinical symptoms in FD patients.


PMID: 26920949

DOI: 10.1111/nmo.12805

Other references

Cao, Y.; Zhou, H.; Qian, R-Can.; Liu, J.; Ying, Y-Lun.; Long, Y-Tao., 2017: Analysis of the electron transfer properties of carbon quantum dots on gold nanorod surfaces via plasmonic resonance scattering spectroscopy. Carbon quantum dot wrapped gold nanorods were fabricated on an ITO electrode surface via electrostatic interactions. The electron transfer properties of carbon quantum dots on gold nanorod surfaces were systematically investigated by plasmonic res...

Xu, Xing., 1997: A new psittacosaur Psittacosaurus mazongshanensis sp nov from Mazongshan area, Gansu Province, China. Unknown

Petrů, Kára.; Jáč, P.; Lužová, V.; Kuneš, Jří.; Polášek, M., 2011: Determination of muscle relaxants pancuronium and vecuronium bromide by capillary electrophoresis with capacitively coupled contactless conductivity detection. A novel capillary electrophoretic method for the separation of pancuronium (PM) and vecuronium (VM) ions utilizing capacitively coupled contactless conductivity detection was devised and validated. The separation was carried out in bare fused-sili...

Chadwick, CE., 1984: Obituary. Ramon Mascord 1913-1983. Royal Zoological Society New South Wales Entomology Section Circular, 29-33 No. 32

Hendrix, R.; Madras, N.; Johnson, R., 1993: Growth pressure can drive early chick lens geometries. Over a number of morphological stages during chick lens morphogenesis, a flat plate of cuboidal ectodermal cells infolds to form a deep cup of tall, pyramidal lenticular cells. This invagination process is accompanied by asynchronous cellular mult...

Khan, A.I.; Dinh, D.M.; Schneider, D.; Lenski, R.E.; Cooper, T.F., 2011: Negative epistasis between beneficial mutations in an evolving bacterial population. Epistatic interactions between mutations play a prominent role in evolutionary theories. Many studies have found that epistasis is widespread, but they have rarely considered beneficial mutations. We analyzed the effects of epistasis on fitness fo...

Dangeard Louis; Rioult M., 1961: Observations sur les traces d'organismes fouisseurs dans les minerais de fer ordoviciens de Basse-Normandie et sur l'importance de la bioturbation. Describes holes and tubular tunnels in the Ordovician oolitic iron ores of lower Normandy, France, that are the result of the action of burrowing animals. These are found in the hematite, in the carbonate, and in the chloritic partings throughout...

James, S.P., 1911: Notes on Mosquitoes. i. The Indian Anophelinae. Paludism Simla, 2 52-63

Akesson, Hans Olof, 1965: Cutis verticis gyrata and mental deficiency in Sweden. A series of 47 patients with a combination of cutis verticis gyrata and mental deficiency, 46 men and 1 woman, yielded the following data of genetic interest. (The epidemio-logic and clinical data have been previously reported.) The sex-chromatin...

Khaziyev, F.K.; Gul'ko, A.Y., 1992: Enzymatic activity of soils in agrocenoses and prospects for their study. Eurasian Soil Science 24(3): 43-58