+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment

, : Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment. Cns Spectrums 20(3): 280-286

Elevations of impulsive behavior have been observed in a number of serious mental illnesses. These phenomena can lead to harmful behaviors, including violence, and thus represent a serious public health concern. Such violence is often a reason for psychiatric hospitalization, and it often leads to prolonged hospital stays, suffering by patients and their victims, and increased stigmatization. Despite the attention paid to violence, little is understood about its neural basis in schizophrenia. On a psychological level, aggression in schizophrenia has been primarily attributed to psychotic symptoms, desires for instrumental gain, or impulsive responses to perceived personal slights. Often, multiple attributions can coexist during a single aggressive incident. In this review, I discuss the neural circuitry associated with impulsivity and aggression in schizophrenia, with an emphasis on implications for treatment. Impulsivity appears to account for a great deal of aggression in schizophrenia, especially in inpatient settings. Urgency, defined as impulsivity in the context of strong emotion, is the primary focus of this article. It is elevated in several psychiatric disorders, and in schizophrenia, it has been related to aggression. Many studies have implicated dysfunctional frontotemporal circuitry in impulsivity and aggression in schizophrenia, and pharmacological treatments may act via that circuitry to reduce urgency and aggressive behaviors; however, more mechanistic studies are critically needed. Recent studies point toward manipulable neurobehavioral targets and suggest that cognitive, pharmacological, neuromodulatory, and neurofeedback treatment approaches can be developed to ameliorate urgency and aggression in schizophrenia. It is hoped that these approaches will improve treatment efficacy.


PMID: 25900066

DOI: 10.1017/S1092852915000206

Other references

Tardieu Blot, M.L., 1963: The spores of the Lindsayoideae and Dennstaedtioideae of Madagascar and the Mascarene Islands, palynological study applied to taxonomy. This palynological study presents characters which make it possible to separate very closely related genera. The Lindsayoideae(except for Sphenomeris)have generally tetrahedric spores. The Dennstaedtiaideae have more variable spores, monolete in H...

Gartner, S.; Charlot, C.; Paris Pireyre, N., 1984: Microanalysis of silica and resistance to mechanical lodging in bread wheat. In studies of one variety resistant to lodging (Tarasque) and one susceptible variety (521) grown in the field under the same conditions, the silica content of the stems was assessed using X-ray microanalysis. The two varieties were of similar hei...

Flaherty, D.L.; Wilson, L.T.; Stern, V.M.; Kido, H., 1985: Biological control in San Joaquin Valley vineyards. The biological control of diseases and arthropod pests of grapevines in the San Joaquin Valley, California is reviewed and some recommendations are presented.

Riman, C.; Hallal, H.; Monacelli, E.; Baklouti, M., 2015: Fuzzy Adjustment Control in Command Evaluation Platform. For motor handicapped persons, the use of computer interface devices could be a challenging task. Two research venues have been explored to address the usability problem for handicapped users of computer systems. In the first, the focus is on deve...

Kabanov, A.V.; Gebhart, C.L.; Bronich, T.K.; Vinogradov, S.V., 2002: Polycations for gene delivery Problems and solutions. Abstracts of Papers American Chemical Society 224(1-2): POLY 672

Savolainen, M.J., 1977: Stimulation of hepatic phosphatidate phospho hydrolase ec activity by a single dose of ethanol. An acute ethanol load (5 g/kg body wt) given by gastric intubation to fasted rats caused a significant increase in phosphatidate phosphohydrolase [EC] activity in the soluble fraction of the liver. The activity was 2-fold at 8 h and 3-fold...

Slacik Josef, 1973: Photoluminescence in the caves of the Moravian karst, Czechoslovakia. Die Hoehle 24(3): 116-123

Rosentreter, A.; Schild, A.M.; Wedemeyer, I.; Dietlein, T.S., 2011: Epithelial downgrowth 48 years after penetrating eye trauma. Epithelial invasion is a rare but severe complication after penetrating eye trauma or intraocular surgery. Cystic ingrowth can occur even after decades. A 53-year-old woman developed two epithelial cysts in the left eye 48 years after penetrating...

Bosetti, F.; Weerasinghe, G.R., 2004: The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse. We examined brain phospholipase A2 (PLA2) activity and the expression of enzymes metabolizing arachidonic acid (AA) in cytosolic PLA2 knockout () mice to see if other brain PLA2 can compensate for the absence of cPLA2 alpha and if cPLA2 couples wi...

Röthlin, M.; Metzger, U.; Joller, H.; Largiadèr, F., 1988: The tumor markers CA 19.9, Ca 50 and CEA in the differential diagnosis of pancreatic carcinoma. The tumour markers CA 19.9, CA 50 and CEA were measured preoperatively in 178 patients with symptoms of the upper abdomen and in 30 healthy individuals. Raising the cutoff of CA 19.9 and CA 50 and combining the three markers resulted in a sensitiv...