geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Incidence and Risk Factors of Hypomagnesemia in Head and Neck Cancer Patients Treated with Cetuximab


, : Incidence and Risk Factors of Hypomagnesemia in Head and Neck Cancer Patients Treated with Cetuximab. Frontiers in Oncology 6(): 196-196

Hypomagnesemia is a common adverse event during cetuximab (Cmab) treatment. However, few reports have investigated the incidence and risk factors of hypomagnesemia in head and neck cancer patients treated with Cmab. We retrospectively reviewed 131 head and neck cancer patients who received Cmab-containing therapy. Main eligibility criteria were ≥3 Cmab administrations, no prior EGFR-directed therapy, and no prophylactic Mg supplementation. Median baseline serum Mg level and number of Cmab administrations were 2.2 mg/dl and 8, respectively. Overall incidence of hypomagnesemia was 50.4% (grade 1, 46.6%; grade 2, 3.1%; grade 3, 0%; and grade 4, 0.8%) and differed between patients treated with palliative chemotherapy and bioradiation (Cmab and radiation) (63 versus 24%; P < 0.01). Independent risk factors were low baseline serum Mg [odds ratio (OR) 161.988, 95% confidence interval (CI) 9.436-2780.895], ≥7 Cmab administrations (OR 3.56, 95% CI 1.16-13.98), and concurrent administration of platinum (cisplatin; OR 23.695, 95% CI 5.219-107.574, carboplatin; OR 5.487, 95% CI 1.831-16.439). Respective incidence of hypomagnesemia in patients in high- (concurrent platinum and ≥7 Cmab administrations) and low-risk (no concurrent platinum and <7 Cmab administrations) groups was 66.0 and 6.6% (P < 0.001, OR 28.0). Cmab is associated with a significant risk of hypomagnesemia in patients with head and neck cancer with longer term administration and concurrent platinum therapy. High-risk patients should be treated with particular care.

US$19.90

PMID: 27683640

DOI: 10.3389/fonc.2016.00196


Other references

Kurasawa Hajime; Yoshida Y.; Mudrey M.G.J., 1974: Geologic log of the Lake Vida Core; DVDP 6. Bulletin - Dry Valley Drilling Project (DVDP) 3: 92-108

Suzuki, H., 1995: Exercise intensity and renal hemodynamics. This study investigated the effects of exercise intensity on renal hemodynamics. Three healthy male subjects underwent exercise tests on a bicycle ergometer at 7 different work loads for 15 min. The indicators of exercise intensity employed in thi...

Eischen, C.M.; Lozano, G., 2009: p53 and MDM2: antagonists or partners in crime?. Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2 to target hnRNP K for degr...

Guano, F.; Bernardi, R.; Negri, C.; Donzelli, M.; Prosperi, E.; Ricotti, G.A.; Scovassi, A.I., 1994: Dose-dependent zinc inhibition of DNA ladder in apoptotic HeLa cells regulates the activity of poly(ADP-ribose) polymerase and does not protect from death induced by VP-16. Zinc ions exert an inhibitory effect on Ca(2+)Mg(2+)-dependent endonuclease which is supposed to be responsible for the fragmentation of DNA during apoptosis. In the experimental system we used, that is HeLa cells treated with VP-16, the protectio...

Bouza, E.; Hortal, F.J.; Munoz, P.; Perez, M.J.; Desco, M.; Riesgo, M.; Hiesmayr, M.; Esgni And Ewci Study Group, 2003: A European perspective on the incidence of postoperative infections in patients undergoing major heart surgery. Objectives: To assess the incidence and type of infections suffered by patients undergoing MHS in European postsurgical ICUs. Materials and Methods: A questionnaire was sent to participating MHS ICUs in Europe requesting hospital and ICU informati...

Gaudio, C.; Tanzilli, G.; Collatina, S.; Pagnotta, P.; Paknejad, K.; Campa, P.P., 1992: Evaluation of regression of left ventricular hypertrophy in hypertensive patients treated with captopril as assessed by magnetic resonance imaging. Magnetic resonance imaging (MRI) was used to assess left ventricular mass (LVM) in 20 mild to moderate essential hypertensive patients with left ventricular hypertrophy (LVH) (LVM > 120 g/m2), treated with captopril alone or combined with hydro...

Oosterhuis, B.; Braat, M.C.; van Boxtel, C.J., 1984: Analysis of beta-sympathicomimetics in man with high performance liquid chromatography using mode sequencing and electrochemical detection. European Journal of Respiratory Diseases. Supplement 135: 153-156

Krishnakumar, D.; Pickard, J.D.; Czosnyka, Z.; Allen, L.; Parker, A., 2014: Idiopathic intracranial hypertension in childhood: pitfalls in diagnosis. Idiopathic intracranial hypertension (IIH) is prone to misdiagnosis. Our aim was to identify the reasons for this in children in our region referred for suspected IIH. We reviewed the records of all children referred with symptoms and/or signs con...

Thompson, N., L.; Pearce, K., H.; Hsieh, H., V., 1993: Total internal reflection fluorescence microscopy: Application to substrate-supported planar membranes. The use of total internal reflection illumination in fluorescence microscopy (TIRFM) is reviewed with emphasis on application to fluorescent macromolecules that specifically and reversibly bind to planar model membranes supported on glass or quart...

Bernards, A.T.; Dijkshoorn, L.; Van der Toorn, J.; Bochner, B.R.; Van Boven, C.P., 1995: Phenotypic characterisation of Acinetobacter strains of 13 DNA-DNA hybridisation groups by means of the biolog system. A collection of 129 Acinetobacter strains belonging to DNA groups (genomic species) 1-14 (1-7 and 10-12 sensu Bouvet and Grimont; 8 and 13-14 sensu Tjernberg and Ursing) were investigated for their ability to oxidise 95 carbon sources in the Biolo...