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Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation

, : Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation. Gut Microbes 6(1): 48-56

The mucosal microbiota lives in close proximity with the intestinal epithelium and may interact more directly with the host immune system than the luminal/fecal bacteria. The availability of nutrients in the mucus layer of the epithelium is also very different from the gut lumen environment. Inferred metagenomic analysis for microbial function of the mucosal microbiota is possible by PICRUSt. We recently found that by using this approach, actively inflamed tissue of ulcerative colitis (UC) patients have mucosal communities enriched for genes involved in lipid and amino acid metabolism, and reduced for carbohydrate and nucleotide metabolism. Here, we find that the same bacterial taxa (e.g. Acinetobacter) and predicted microbial pathways enriched in actively inflamed colitis tissue are also enriched in the mucosa of subjects undergoing routine screening colonoscopies, when compared with paired samples of luminal/fecal bacteria. These results suggest that the mucosa of healthy individuals may be a reservoir of aerotolerant microbial communities expanded during colitis.


PMID: 25559083

DOI: 10.1080/19490976.2014.1000080

Other references

Rinaldi Carlos A.; Parica Claudio A.; Santillana Sergio N., 1999: The Jurassic and Cretaceous of Patagonia and Antarctica; 8, Cretaceous at the Antarctica Argentinian sector. This discussion of the Cretaceous geology found in the Argentine sector of Antarctica includes the Antarctic Peninsula, Weddell Sea, South Shetland Islands, petrology, lithostratigraphy, and tectonics. (mte).

Borgnis, R.L.; Fox, S.E., 1999: Both glutamate and GABAA activated currents contribute to the phasic theta-related sink at the hippocamal fissure. Society for Neuroscience Abstracts 25(1-2): 634

Shinder, R.; Gutman, J.; Gunasekera, C.D.; Connor, M.; Nakra, T., 2012: Occult orbital organic foreign body. Ophthalmic Plastic and Reconstructive Surgery 27(6): 463-464

Kramer P.M.; Marco M.P.; Hammock B.D., 1992: Individual determination of carbaryl and 1 naphthol by elisa. Abstracts of Papers American Chemical Society 203(1-3): AGRO199

Cherian, M.C.; Margabandhu, V., 1942: A new species of Trichospilus Hym Chalcidoidea from South India. Indian Journal of Entomology, 4: 101-103

Eaton, A.; Eksi, S.; Wassom, D.; Powell, M., 1993: Co-inheritance of cytokine profiles and resistance to acute Trypanosoma cruzi infection. Journal of Immunology 150(8 PART 2): 69A

Mitchell, D., 1996: Learning disability nursing in the post war period. This paper considers the place of learning disability nursing within the profession in the 1940's and 1950's. A number of sources are discussed, which throw light on the problem of recruitment to this branch of nursing as well as its fut...

Lin, S-Yuan.; Chiang, H-Ying.; Chen, I-Ling., 2012: Comparing nurses' intent to leave or stay: differences of practice environment perceptions. Few existing studies have compared nurses' perceptions of the practice environment in relation to intent to leave or stay in employment and nursing concurrently. This study compared the differences between Taiwanese nurses' intent to lea...

Zhang, H.; Xu, M.; Li, B., 2016: Synthesis of a Novel Phosphorus-Containing Flame Retardant Curing Agent and Its Application in Epoxy Resins. A novel phosphorus-containing compound diphenyl-(2,5-dihydroxyphenyl)-phosphine oxide defined as DPDHPPO was synthesized and used as flame retardant and curing agent for epoxy resins (EP). The chemical structure was well characterized by Fourier t...

Detrie, P., 1952: Phlebitis of the inferior vena cava, a clinical and experimental study. La Presse Medicale 60(13): 269-271