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Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression


, : Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression. International Journal of Clinical and Experimental Pathology 8(12): 15954-9

The present study demonstrates the effect of rubriflordilactone on lipopolysaccharide (LPS)-induced acute kidney injury in rats and MLE-15 cells. LPS administration in rats resulted in formation of edema which was inhibited by pretreatment with rubriflordilactone. The pulmonary tissues of LPS administered rats and MLE-15 cells showed a significant increase in the expression of matrix metalloproteinase-9, interleukin-6 and inducible nitric oxide synthase. However, rubriflordilactone treatment prior to LPS administration caused a significant reduction in the expression of these factors at a concentration of 10 nm/kg. Analysis of the Sirtuin 1 (Sirt1) expression revealed significant (P=0.002) reduction on exposure to LPS in MLE-15 cells. However, rubriflordilactone treatment at 10 nm/ml concentration before LPS exposure caused inhibition of LPS induced reduction in Sirt1 expression. Silencing of Sirt1 by siRNA in MLE-15 cells led to inhibition of increased Sirt1 expression by rubriflordilactone in LPS administered rats. These findings suggest that rubriflordilactone inhibits LPS induced acute lung injury in rats and MLE-15 cells through promotion of Sirt1 expression.

US$29.90

PMID: 26884869


Other references

Walzl, Manfred-Gunther, 1992: Ultrastructure of the reproductive system of the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari, Pyroglyphidae) with remarks on spermatogenesis and oogenesis. Several parts of the reproductive system of both sexes of Dermatophagoides farinae and D. pteronyssinus are investigated and compared by light-, scanning electron-, and transmission electron microscopy. New techniques have been employed for scanni...

Der O.C.; Gowans C.S., 1972: Tri carboxylic acid enzymes in obligate autotrophic and facultative autotrophic species and in acetate mutants of chlamydomonas. Canadian Journal of Genetics & Cytology 14(3): 723-724

Mikaberidze, Ve, 1975: Intensity of photosynthesis of citrus plants under various temperaturs in relation to their frost resistance. Subtropicheskie kul'tury: 65-68

Ossiprandi, M.C.; Cattabiani, F.; Risio, L. de; Bottarelli, E., 2006: Antibiotic resistance in bacteria isolated from urinary tracts of cats and dogs with neurologic impairment. Multiple risk factors may be involved in canine and feline urinary tract infections (UTI). Among these, spinal cord injury (SCI) or neurological deficit/impairments in particular can interfere with micturition. No large retrospective studies on th...

Olafsson, E.B.; Peterson, C.H.; Ambrose, W.G.; Jr., 1994: Does recruitment limitation structure populations and communities of macro-invertebrates in marine soft sediments: the relative significance of pre- and post-settlement processes. Oceanography and Marine Biology an Annual Review, 32: 65-109

Ekizashvili, V.K.; Rapava, E.A.; Kalandarishvili, F.A., 1981: Changes in the activity of different forms of RNA polymerase in the rat brain during postnatal development. The dynamics of various forms of RNA-polymerases of the rat's brain was studied in the course of postnatal development, using autoradiography and fractionation of enzyme preparation purified from the matrix DNA admixture. In the brain of new-...

Kim, B.; Park, J.H.un; Hwang, G.; Jun, M.S.g; Choi, K., 2001: Eutrophication of reservoirs in South Korea. Natural lakes in South Korea are limited in number and generally quite small. As a result, reservoirs and regulated rivers are the major sources of freshwater for society. About 18000 reservoirs have been constructed in South Korea, and they are p...

Tuell, J.K.; Isaacs, R., 2010: Community and species-specific responses of wild bees to insect pest control programs applied to a pollinator-dependent crop. Wild bee conservation is regarded as essential for sustainable production of pollinator-dependent crops, yet little is known about the effects on wild bee communities of typical insect pest management programs used postbloom. We developed an insec...

Ladher, R.; Mohun, T.J.; Smith, J.C.; Snape, A.M., 1996: Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4. Bone morphogenetic protein-4 (BMP-4) is thought to play an important role in early Xenopus development by acting as a "ventralizing factor' and as an epidermal determinant: local inhibition of BMP-4 function in whole embryos causes the f...

Okumura Koji; Ikeda Kuniaki; Endo Hidenori, 1993: Ground disaster caused by the Kushiro-Oki earthquake 1993. Chishitsu News: 2, Pages 41-42. 1993.