+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits

, : Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits. Food Chemistry 132(1): 385-390

Foeniculum vulgare fruits are routinely consumed for their carminative and mouth freshening effect. The plant was evaluated for aldose reductase inhibition and anti-diabetic action. Bioguided fractionation using silica gel column chromatography, HPLC, and GC-MS analysis revealed trans-anethole as the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value of 3.8μg/ml. Prolonged treatment with the pet ether fraction of the F. vulgare distillate demonstrated improvement in blood glucose, lipid profile, glycated haemoglobin and other parameters in streptozotocin-induced diabetic rats. Trans-anethole could effectively show anti-cataract activity through the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vitro incubation of the eye lens with 55mM glucose. Trans-anethole demonstrated noncompetitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.


PMID: 26434305

DOI: 10.1016/j.foodchem.2011.11.005

Other references

Surkov Aleksandr Vladimirovich; Semenov Sergey Vladimirovich, 2002: Traditional and new approaches to the study of placers and sedimentary rocks. Pages 27-32 2002

Aszodi, A.; Hunziker, E.B.; Brakebusch, C., 2003: B1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. b1 integrins are highly expressed on chondrocytes, where they mediate adhesion to cartilage matrix proteins. To assess the functions of b1 integrin during skeletogenesis, we inactivated the b1 integrin gene in chondrocytes. We show here that these...

Stocki, E., 1971: Medical history of ancient Gniezno. Polski Tygodnik Lekarski 26(43): 1681-1683

Metcalfe J.A.; Stratford B., 1986: Development of perception and cognitive abilities among nonhandicapped children and children with down syndrome. Evidence is presented concerning the development of performance among 162 nonhandicapped and 128 Down Syndrome children on (a) a simple visual matching task, (b) a simple visual memory task, and (c) the Peabody Picture Vocabulary Test. Particular...

Zheng, Y.; Cai, C.; Zhang, F.; Monty, J.; Linhardt, R.J.; Simmons, T.J., 2016: Can natural fibers be a silver bullet? Antibacterial cellulose fibers through the covalent bonding of silver nanoparticles to electrospun fibers. Natural cotton was dissolved in a room-temperature ionic liquid 1-ethyl-3-methyl acetate and wet-jet electrospun to obtain nanoscale cotton fibers with a substantially reduced diameter-and therefore an increased surface area-relative to natural co...

Karbwang, J.; N.B.ngchang, K., 1994: Clinical application of mefloquine pharmacokinetics in the treatment P falciparum malaria. Malaria remains a major public health problem in large areas of the world. One of the major factors responsible for the resurgence is the emergence of Plasmodium falciparum, resistant to available antimalarials. An antimalarial, mefloquine, has be...

Bromwich, R., 2016: Considering Tort Liability for Breaches to Privacy of Patient Data-- Managing Risks of Applicability of Privacy Torts, and Especially the Tort of "Intrusion on Seclusion" in the Health Context. The mobile revolution is a watershed event across many fields, including health care. Now, electronic data storage, digital photography, smart phones and tablet devices present new opportunities for educators, researchers, and health care provider...

Ampova, G., 1966: Soil microflora in tobacco seedbeds as influenced by the herbicide Vapam. Vapam at 25, 50 and 100 g/m2was applied 10 days before sowing tobacco in laboratory and field trials in 1965-66. Treated seedlings developed larger root systems and longer stems and were ready for transplanting 9 days before the controls. Herbicid...

Dammann, H.G.; Flasshoff, D.; Müller, P.; Kather, H.; Simon, B., 1982: Ranitidine and intragastric pH profiles in seriously ill patients. Digestive Diseases and Sciences 27(2): 187-188

Menke, J.A.; Miles, R.; McIlhany, M.; Bashiru, M.; Chua, C.; Schwied, E.; Menten, T.G.; Khanna, N.N., 1982: The fontanelle tonometer: a noninvasive method for measurement of intracranial pressure. The use of a modified pneumotonometer as a noninvasive method to measure intracranial pressure through the fontanel was evaluated in the animal laboratory and in the clinical setting. Pressure measured with the tonometer from a surgically created...