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Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer

, : Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. Oncotargets and Therapy 9(): 2317-2327

Integrin expression has been identified as a prognostic factor in non-small-cell lung cancer (NSCLC). This study was aimed at determining the predictive ability of integrins and associated genes identified within the molecular network. A total of 959 patients with NSCLC from The Cancer Genome Atlas cohorts were enrolled in this study. The expression profile of integrins and related genes were obtained from The Cancer Genome Atlas RNAseq database. Clinicopathological characteristics, including age, sex, smoking history, stage, histological subtype, neoadjuvant therapy, radiation therapy, and overall survival (OS), were collected. Cox proportional hazards regression models as well as Kaplan-Meier curves were used to assess the relative factors. In the univariate Cox regression model, ITGA1, ITGA5, ITGA6, ITGB1, ITGB4, and ITGA11 were predictive of NSCLC prognosis. After adjusting for clinical factors, ITGA5 (odds ratio =1.17, 95% confidence interval: 1.05-1.31) and ITGB1 (odds ratio =1.31, 95% confidence interval: 1.10-1.55) remained statistically significant. In the gene cluster network analysis, PLAUR, ILK, SPP1, PXN, and CD9, all associated with ITGA5 and ITGB1, were identified as independent predictive factors of OS in NSCLC. A set of genes was identified as independent prognostic factors of OS in NSCLC through gene cluster analysis. This method may act as a tool to reveal more prognostic-associated genes in NSCLC.


PMID: 27143927

DOI: 10.2147/OTT.S91796

Other references

Fassl, A.H., 1922: Neue Schmetterlingsformen aus Brasilien. Entomologische Zeitschrift Frankfurt a M: 36: 38-39, 42-43, 45-46

Anonymous, 1999: Geology and wetlands. Colorado Geological Survey ROCKTALK 2(2): 11

Fukumori, T.; Takenaka, Y.; Yoshii, T.; Kim, H-Reh.Choi.; Hogan, V.; Inohara, H.; Kagawa, S.; Raz, A., 2003: CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. Galectin (Gal)-3, a M(r) 31000 member of the beta-galactoside-binding protein family, is a multifunctional protein implicated in a variety of biological functions, including tumor cell adhesion, proliferation, differentiation, angiogenesis, apopto...

Morisawa, Y.; Dyakov, Y.A.; Tseng, C-Ming.; Lee, Y.T.; Ni, C-Kung., 2008: Photodissociation dynamics of 2,5-dihydroxyacetophenone. Photodissociation of 2,5-dihydroxyacetophenone (DHAP), an important matrix compound in matrix-assisted laser desorption/ionization (MALDI), was studied in a molecular beam at 193 nm using multimass ion imaging techniques. Two major dissociation ch...

Mindt, G.; Becker, J., 2001: Oidium specialist VentoReg. - a component of successful resistance management. Since 1999, the fungicidal preparation Vento (quinoxyfen + fenarimol) has been approved for use against Uncinula necator in grapes in Germany. Information is provided on formulation, mode of action, mammalian toxicity, nontarget effects and applic...

Salvador-Carulla, L.; Rodríguez-Blázquez, C., 2004: Psychosocial modifiers of drug prescription: the hidden face of pharmacology?. Apart from placebo, there is scant medical knowledge regarding the influence of psychosocial effect modifiers in pharmacology. Phenomena such as the nocebo, Hawthorne, Oedipus and complacency effects have been previously described as sources of bi...

Henriques, S.T.oeira; Costa, J.; Castanho, M.A.R.B., 2005: Translocation of b-Galactosidase Mediated by the Cell-Penetrating Peptide Pep-1 into Lipid Vesicles and Human HeLa Cells Is Driven by Membrane Electrostatic Potential. Biochemistry (American Chemical Society) 44(30): 189-98

Anonymous, 1983: Abortion risks for teens as low as or lower than risks for older women. Family Planning Perspectives 15(6): 282-283

Gryazev, V.A., 1979: Productivity of vegetatively propagated mother plants of apple rootstocks at different spacings. In trials with numerous clonal rootstocks, the recommende spacing for types showing a low coefficient of stool shoot productivity (M.2, M.9, 1-48-41 and MM.106) was 200 X 25 cm and it was 200 X 40 cm for those showing a high coefficient (M.3, M.7...

Himizu, J.; Shichita, T., 1965: B-homoprogesterone. Chemical & Pharmaceutical Bulletin 13(9): 1145-1147