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Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner

, : Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner. Biochimica et Biophysica Acta 1858(2): 281-288

It has been a long-standing question how the two leaflets in a lipid bilayer modulate each others' physical properties. In this paper, we discuss how this interaction may take place through interdigitation. We use atomistic molecular dynamics simulations to consider asymmetric lipid membrane models whose compositions are based on the lipidomics data determined for exosomes released by PC-3 prostate cancer cells. The simulations show interdigitation to be exceptionally strong for long-chain sphingomyelin (SM) molecules. In asymmetric membranes the amide-linked chain of SM is observed to extend deep into the opposing membrane leaflet. Interestingly, we find that the conformational order of the amide-linked SM chain increases the deeper it penetrates to the opposing leaflet. Analysis of this finding reveals that the amide-linked SM chain interacts favorably with the lipid chains in the opposite leaflet, and that cholesterol modulates the effect of SM interdigitation by influencing the conformational order of lipid hydrocarbon chains in the opposing (cytosolic) leaflet.


PMID: 26654782

DOI: 10.1016/j.bbamem.2015.12.003

Other references

Mercier J.; Vergely P., 1994: Is the Paikon Massif a tectonic window in the Axios-Vardar Zone? internal Hellenides, Macedonia, Greece. It has been recently proposed that the Paikon Massif would be a tectonic window beneath a large ophiolitic nappe. This nappe would have been thrust westward from the Guevgueli ophiolitic massif onto the Pelagonian Massif over the Late Cretaceous l...

Solt G.S., 1973: Phosphorus in industrial water. Water Research: 69-75

Germagnoli, L.; Lopez Silva, S.; Murone, M.; Vazzana, S.; Grassini, L.; Calloni, L.; Gioia, V., 1999: Evaluation of the automatic system Test-1 for measurement of the erythrocyte sedimentation rate. Clinical Chemistry 45(6 PART 2): A100, June

Bikbulatova, N.N., 1995: Study of the anti-candidosis activity of ultraviolet light. The effect of UV radiation was tested on cultures of Candida albicans in order to find the optimal irradiation dose (determined at 6-10 min from a distance of 30 cm) and the zone of growth inhibition; a ray 0.8 cm in diameter at a distance of 2-4...

Shnider S.M.; Leong Way E., 1968: The kinetics of transfer of lidocaine metab xylocaine metab across the human placenta. Anesthesiology (Hagerstown) 29(5): 944-950

Kim, S-Heon.; Kim, S-Hoon.; Yoon, H.Joo.; Shin, D.Ho.; Park, S.Soo.; Kim, Y-Seup.; Park, J-Seuk.; Jee, Y-Koo., 2012: TNF-α genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis. While the mechanisms underlying the development of drug-induced liver injury are not clear, there is evidence to suggest that tumor necrosis factor-α (TNF-α) plays an important role in drug- or drug metabolite-induced immune responses. We hypoth...

Grosieux, P., 1970: Primary amenorrhea, sterility and human gonadotrophins. Revue Francaise de Gynecologie et D'obstetrique 65(3): 101-102

Ung, J.E.; Dozier, M.E.; Bratiotis, C.; Ayers, C.R., 2016: An Exploratory Investigation of Animal Hoarding Symptoms in a Sample of Adults Diagnosed With Hoarding Disorder. The extant research on animal hoarding has a dearth of information on animal hoarding tendencies in adults diagnosed with hoarding disorder (HD). In the present study, we investigated possible recurrent animal hoarding behavioral and symptom patte...

Suljga, P.M., 1952: Intergeneric hybridization of the pea.. Breeding peas for resistance to lodging at the Uladovo-Ljulinec Breeding Research Station includes vegetative hybridization. The material comprised grafts of the pea varieties Uladovskii 208 and Uladovskil 387 and some promising new pea hybrids on...

Hill, C.W.; Combriato, G., 1973: Genetic duplications induced at very high frequency by uv irradiation in escherichia coli. Molecular and General Genetics 127(3): 197-214