+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Interrelationships with Metabolic Syndrome, Obesity and Cardiovascular Risk

, : Interrelationships with Metabolic Syndrome, Obesity and Cardiovascular Risk. Current Vascular Pharmacology 14(5): 415-425

NlmCategory="UNASSIGNED">Cardiovascular (CV) disease is the most common cause of morbidity and mortality worldwide, particularly in the presence of the metabolic syndrome (MetS). Classifications and treatment of the MetS have recently been redefined. While the majority of the cardiac components such as hypertension, diabetes mellitus (DM) and dyslipidemia (DLD) are objectively measurable elements, a few disparities among the definitions have to be considered that can variably modify diagnosis, treatment and prevention. Non-cardiac factors such as liver disease (including, but not limited to, alcoholic and non-alcoholic steatosis/hepatitis), renal disease, severe obesity, polycystic ovarian syndrome and obstructive sleep apnea (OSA), may have independent or synergistic relationship with complementary cardiac MetS elements, and these additional risk factors may have an incremental adverse impact on CV outcome. The combination of all these factors potentiates the adverse significance on CV events. MetS not only increases morbidity and mortality but also has economic ramifications for the healthcare system. Prevention of CV disease includes primary and secondary aspects. Besides overall advances to provide optimal care for hypertension, diabetes, and dyslipidemia, early-targeted inventions to diagnose, treat and prevent OSA, and severe obesity, are needed.


PMID: 27456105

Other references

Ugen K.E.; Goedert J.; Kieber Emmons T.; Merva M.; Boyer J.; Williams W.V.; Weiner D.B., 1991: Inhibition of hiv 1 infection by immunological reagents. Istituto Superiore Di Sanita Vii International Conference on Aids: Science Challenging Aids; Florence, Italy, June 16-21, 464p (Vol 1); 460p (Vol 2) Istituto Superiore Di Sanita: Rome, Italy Paper : 40

Singh; Stoessel; Wolynes, 1985: Hard-sphere glass and the density-functional theory of aperiodic crystals. Physical Review Letters 54(10): 1059-1062

Overman, R.R.; Davis, A.K.; Bass, A.C., 1951: Effect of cortisone and DCA on Na24 transport in normal dogs. Fed Proc 10(1): 100

Bronnvall, A.M.; Larsson, J.I.R.nny, 2001: Ultrastructure and light microscopic cytology of Agglomerata lacrima n sp , a microsporidian parasite of Acanthocyclops vernalis. Agglomerata lacrima n. sp. is the first species of the genus described from a copepod host (Acanthocyclops vernalis.) It was studied using light- and electron-microscopy. All stages of the life-cycle had isolated nuclei. The earliest stages found...

Park, W.; Madsen, E.L., 2002: Interaction of the NahR, a LysR-type transcriptional activator, with alpha subunit of RNA polymerase in naphthalene degrading bacterium, Pseudomonas putida NCIB 9816-4. NahR, a LysR-type transcriptional activator, is required for activation of naphthalene catabolic operons, however, detailed mechanisms of transcriptional activation by NahR are incompletely understood. Many transcriptional activators function by m...

Riffee, W.H.; Wilcox, R.E.; Vaughn, D.M.; Smith, R.V., 1982: Dopamine receptor sensitivity after chronic dopamine agonists. Striatal 3H-spiroperidol binding in mice after chronic administration of high doses of apomorphine, N-n-propylnorapomorphine and dextroamphetamine. Several previous reports have demonstrated that chronic administration of both directly and indirectly acting dopamine agonists produces a supersensitive behavioral response to challenge doses of dopamine agonists when compared to the responses in...

Lee, S.Ku.; Yoon, D.Wui.; Yi, H.; Lee, S.Woo.; Kim, J.Yeol.; Kim, J.Kwan.; Hong, J.Hwa.; Shin, C., 2015: So-eum type as an independent risk factor for irritable bowel syndrome: a population-based study in Korea. It has been hypothesized that Sasang constitutional types (SCTs) have a specific hypoactive organ, which can account for vulnerability to related diseases or symptoms. This study examined the relationship between SCTs and irritable bowel syndrome...

Dudding, T.C.; Meng Lee, E.; Faiz, O.; Parés, D.; Vaizey, C.J.; McGuire, A.; Kamm, M.A., 2008: Economic evaluation of sacral nerve stimulation for faecal incontinence. Sacral nerve stimulation (SNS) is an established treatment for faecal incontinence in patients who have failed conservative management. This study established the cost-effectiveness of treating patients with SNS compared with non-surgical treatmen...

Osterhout, W.J., 1945: Effects Of Hydroxyl On Negative And Positive Cells Of Nitella. Remarkable changes are brought about by KOH in transforming negative cells of Nitella (showing dilute solution negative with KOH) to positive cells (showing dilute solution positive with KOH). NaOH is less effective as a transforming agent. This m...

Clench, W.J., 1955: Melania cancellata Say. Nautilus Philadelphia, 68: 107