+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ironing out the details of iron overload in myelofibrosis: Lessons from myelodysplastic syndromes

, : Ironing out the details of iron overload in myelofibrosis: Lessons from myelodysplastic syndromes. Blood Reviews 30(5): 349-356

Myelofibrosis (MF) and myelodysplastic syndrome (MDS) are hematopoietic stem cell disorders associated with cytopenias and red blood cell (RBC) transfusion dependence. Iron overload (IO) as a consequence of RBC transfusion dependence and its effect on outcomes in MF has not been formally studied. However, IO is a demonstrated poor prognostic feature in patients with MDS and congenital or acquired chronic anemias. Evidence that iron chelation therapy (ICT) reduces the deleterious effects of IO in MDS has led to speculation of benefit in MF. However, data supporting the use of ICT in MF is lacking. Neither disease has clear consensus guidelines for the use of ICT. Moreover, JAK-STAT inhibition, the cornerstone of MF treatment, often contributes to anemia and transfusional requirements. This manuscript reviews known and potential implications of IO in MF and highlights the need for prospective clinical investigations of ICT with consideration in the setting of JAK2 inhibitor therapy.


PMID: 27106071

DOI: 10.1016/j.blre.2016.04.003

Other references

D.Freitas, L.M.M., E.Al., 1958: Gibberellic acid: some observations on an application to Panicum maximum. In Sao Paulo State there is shortage of forage during June-Aug. (the coldest and driest months of the year) because of poor plant growth, especially of Panicum maximum, the most important forage species. In a plot trial, gibberellic acid applied t...

Malde Harold E., 1965: Snake River Plain. The Snake River Plain in southern Idaho is composed of two structural parts, a northwest-trending graben in the west, the bounding faults of which coincide with a line of earthquake epicenters that stretches from Puget Sound to Great Salt Lake, an...

Komolafe, R.; Kimani, R.; Jallow, A., 1993: Integrating HIV-positive Africans in HIV/AIDS prevention in Sweden. IXTH INTERNATIONAL CONFERENCE ON AIDS AND THE IVTH STD WORLD CONGRESS [Author] IXth International Conference on AIDS in affiliation with the IVth STD World Congress : 885

Schlueter, R.; Röder, A.; Czekalski, N.; Gliesche, D.; Mikolasch, A.; Schauer, F., 2014: Novel mechanisms of biotransformation of p-tert-amylphenol by bacteria and fungi with special degradation abilities and simultaneous detoxification of the disinfectant. The compound p-tert-amylphenol (p-(1,1-dimethylpropyl)phenol) is a widely used disinfectant belonging to the group of short branched-chain alkylphenols. It is produced in or imported into the USA with more than one million pounds per year and can...

Matthews, G.A., 1992: The transfer of pesticides to the target. The complex interaction of factors influencing the accuracy and efficiency of pesticide application to target species is discussed. Aspects considered include pesticide droplet size, the use of adjuvants, crop areas, economic considerations, the t...

Sedov B.M., 1985: Mapping of permafrost during marine seismic surveys. Pages 147-148 1985

Connolly, K.Kihmm.; Crosby, M.E., 2015: Examining e-Health literacy and the digital divide in an underserved population in Hawai'i. Seeking health information is one of the leading uses for the Internet and World Wide Web (WWW). Research has found the amount one benefits from e-Health information (health information from electronic sources) is directly related to the level of...

Cai, M.; Chen, W.; Dong, D.; Song, L.; Wang, M.; Wang, Z.; Zhou, F.; Zheng, Z.; Yu, C., 2016: Reduction of Kinematic Short Baseline Multipath Effects Based on Multipath Hemispherical Map. NlmCategory="UNASSIGNED">Multipath hemispherical map (MHM) is a kind of multipath mitigation approach that takes advantage of the spatial repeatability of the multipath effect under an unchanged environment. This approach is not only...

Kester, M.H.; van Dijk, C.H.; Tibboel, D.; Hood, A.M.; Rose, N.J.; Meinl, W.; Pabel, U.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Visser, T.J., 1999: Sulfation of thyroid hormone by estrogen sulfotransferase. Sulfation is one of the pathways by which thyroid hormone is inactivated. Iodothyronine sulfate concentrations are very high in human fetal blood and amniotic fluid, suggesting important production of these conjugates in utero. Human estrogen sulf...

Lau, 2000: Gone with the wnts. Trends in Cell Biology 10(11): 463-463