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Laryngeal muscle activity during nasal high-frequency oscillatory ventilation in nonsedated newborn lambs

, : Laryngeal muscle activity during nasal high-frequency oscillatory ventilation in nonsedated newborn lambs. Neonatology 107(3): 199-205

We have previously shown that nasal pressure support ventilation (nPSV) can lead to an active inspiratory laryngeal narrowing in lambs. This, in turn, can limit lung ventilation and divert air into the digestive system, with potentially deleterious consequences. On the other hand, nasal high-frequency oscillatory ventilation (nHFOV) is particularly attractive in newborns, especially since, unlike nPSV, it does not require synchronization with the patient's inspiratory efforts. The main aim of the present study was to test the hypothesis that glottal constrictor muscle activity (EMG) does not develop during nHFOV. A secondary objective was to study laryngeal EMG during nHFOV-induced central apneas. Polysomnographic recordings were performed in 7 nonsedated lambs which were ventilated with increasing levels of nPSV and nHFOV at both 4 and 8 Hz, in random order. States of alertness, diaphragm and glottal muscle EMG, SpO2, and respiratory movements were continuously recorded. While phasic inspiratory glottal constrictor EMG appeared with increasing nPSV levels in 6 out of 7 lambs, it was never observed with nHFOV. In addition, nHFOV at 4 Hz dramatically inhibited central respiratory drive in 4/7 lambs, with 64-100% of recording time spent in central apnea in 3 lambs. No glottal constrictor EMG was observed during these central apneas. nHFOV does not induce glottal constrictor muscle EMG in nonsedated newborn lambs, in contrast to nPSV. This may be an additional advantage of nHFOV relative to nPSV.


PMID: 25660143

DOI: 10.1159/000369120

Other references

Muñoz-Turnbull, J., 1969: Defective intestinal absorption syndrome. Introduction. Gaceta Medica de Mexico 99(11): 1028-1029

Sabratorelli, G., 1967: L'influence favorable du foie embryon-naire sur l'hematopoiese in vitro dans la moelle osseuse de l'embryon de poulet. Journal of Embryology and Experimental Morphology, 17: 359-365

Yamato, S.; Matsueda, K.; Shoda, R.; Muraoka, A.; Matsukawa, M.; Akiyama, J.; Fukushima, S.; Sekigawa, K.; Yamashina, S.; Ohara, H.; Shimizu, K.; Iso, N.; Shimojyo, E.; Umeda, N., 1997: Ambulatory 24-hour esophageal manometry in patients with diffuse esophageal spasm Daily profile of abnormal esophageal contractions and effect of L-arginine. Gastroenterology 112(4 SUPPL ): A855

Ichinose, M.; Nakanishi, H.; Fujino, S.; Tatematsu, M., 1998: Establishment and characterization of two cell lines from N-methyl-N-nitrosourea-induced mouse glandular stomach carcinomas. We previously reported the induction with N-methyl-N-nitrosourea (MNU) of mouse glandular stomach carcinomas showing a gastric phenotype but variation in histologic appearance, as with human gastric carcinomas. In the present study, we established...

Chedija, IO., 1989: Fusulinids. Unknown

Sugimoto T.; Nibe A.; Masuko T., 1987: Comparative study of grouping methods of cows for optimum feeding and management of herds. Journal of Agricultural Science Tokyo Nogyo Daigaku 31(3): 141-150

Huang, L.; Guo, H.; Cheng, M.; Zhao, Y.; Jin, X., 2007: The kinetic change of the serum angiogenin level in patients with acute cerebral infarction. Serum angiogenin (ANG) levels were measured with ELISA in 30 cerebral infarction patients at different time points ( within 48 h and on days 3, 7 and 14 after onset of cerebral infarction) and in 20 control subjects. Serum ANG levels in patients w...

Vallega, V., 1996: The quality of Triticum monococcum L., in perspective. Recent studies on einkorn quality are reviewed particularly those dealing with nutritional and medicinal value, grain and milling characteristics, and rheological and end-use quality.

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