+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats

, : Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats. Frontiers in Neuroanatomy 9: 16-16

Four distinct proteins are regulated in the aging neuroretina and may be regulated in the cerebral cortex, too: peroxiredoxin, beta-synuclein, PARK[Parkinson disease(autosomal recessive, early onset)]7/DJ-1, and Stathmin. Thus, we performed a comparative analysis of these proteins in the the primary somatosensory cortex (S1) and primary visual cortex (V1) in rats, in order to detect putative common development-, maturation- and age-related changes. The expressions of peroxiredoxin, beta-synuclein, PARK[Parkinson disease (autosomal recessive, early onset)]7/DJ-1, and Stathmin were compared in the newborn, juvenile, adult, and aged S1 and V1. Western blot (WB), quantitative reverse-transcription polymerase chain reaction (qRT-PCR), and immunohistochemistry (IHC) analyses were employed to determine whether the changes identified by proteomics were verifiable at the cellular and molecular levels. All of the proteins were detected in both of the investigated cortical areas. Changes in the expressions of the four proteins were found throughout the life-time of the rats. Peroxiredoxin expression remained unchanged over life-time. Beta-Synuclein expression was massively increased up to the adult stage of life in both the S1 and V1. PARK[Parkinson disease (autosomal recessive, early onset)]7/DJ-1 exhibited a massive up-regulation in both the S1 and V1 at all ages. Stathmin expression was massively down regulated after the neonatal period in both the S1 and V1. The detected protein alterations were analogous to their retinal profiles. This study is the first to provide evidence that peroxiredoxin, beta-synuclein, PARK[Parkinson disease (autosomal recessive, early onset)]7/DJ-1, and Stathmin are associated with postnatal maturation and aging in both the S1 and V1 of rats. These changes may indicate their involvement in key functional pathways and may account for the onset or progression of age-related pathologies.


PMID: 25788877

DOI: 10.3389/fnana.2015.00016

Other references

Albarran, J.W., 1996: Exploring the nature of informed consent in coronary care practice. The nature of informed consent is bound within legal and moral duties. An analysis of informed consent includes the elements of understanding, disclosure, competence, voluntariness and authorisation, all of which can be affected by a variety of fa...

Yazawa T.; Kuwasawa K., 1985: Effects of amines and their blockers on excitatory synapses in the cardiac nervous system of crustacean aniculus aniculus. Zoological Science (Tokyo) 2(6): 873

Carey, P.E.; Gerrard, J.; Cline, G.W.; Dalla Man, C.; English, P.T.; Firbank, M.J.; Cobelli, C.; Taylor, R., 2005: Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production. To test the hypothesis that intrahepatic availability of fatty acid could modify the rate of suppression of endogenous glucose production (EGP), acipimox or placebo was administered before and during a test meal. We used a modified isotopic method...

Klotz, K.L.; Finger, F.L.; Shelver, W.L., 2003: Characterization of two sucrose synthase isoforms in sugarbeet root. Two sucrose synthase isoforms (EC have been identified in developing sugarbeet (Beta vulgaris L.) roots. To aid in understanding the physiological significance of these multiple sucrose synthase isoforms, the two isoforms were partially...

Pizzi, C.; Panico, L.; D.M.rchis, L.; Mastranzo, P.;, M.; D'amico, C.; Limite, G.; Pettinato, G.; Cocozza, S.; Bianco, A.R.ffaele; Contegiacomo, A., 2002: P53 expression is decreased in primary breast carcinomas with microsatellite instability. p53 and p185 expression in primary breast cancer with microsatellite instability (MSI) is still largely unexplored. To investigate the relationship between these oncoproteins and the pathways of genomic instability, we examined 52 primary invasive...

Marshall, N.J.; Jennings, K.; Mcfarland, W.N.; Loew, E.R.; Losey, G.S., 2003: Visual biology of Hawaiian coral reef fishes. III. Environmental light and an integrated approach to the ecology of reef fish vision. In the previous two papers in this three-part series, we have examined visual pigments, ocular media transmission, and colors of the coral reef fish of Hawaii. This paper first details aspects of the light field and background colors at the microh...

Reyes, D.R.; Rosario, O.; Rodriguez, J.F.; Jimenez, B.D., 2000: Toxic evaluation of organic extracts from airborne particulate matter in Puerto Rico. In recent years, several hypotheses have emerged to explain the toxicologic activity of particulate matter. Organic compounds, ultrafine particles, biologic components, and transition metals are some of the constituents that reportedly exert some...

Chemisov, Ia, 1977: Arctic Experimental Station of the All Union Research Institute of Plant Industry for the non Chernozem Zone. Biulleten' 1 15-19

Vázquez-Justo, E.; Blanco, A.Piñón.; Vergara-Moragues, E.; Gestoso, C.Guillén.; Pérez-García, M., 2015: Cognitive reserve during neuropsychological performance in HIV intravenous drug users. HIV-associated neurocognitive disorders are frequently observed in people with HIV. We aimed to evaluate the influence of cognitive reserve on the neuropsychological performance of seropositive drug users. We carried out a neuropsychological asses...

Berger A.J., 1972: Hawaiian birds 1972. Wilson Bulletin 84(2): 212-222