+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Liver metabolic activity changes over time with neoadjuvant therapy in locally advanced rectal cancer

, : Liver metabolic activity changes over time with neoadjuvant therapy in locally advanced rectal cancer. Nuclear Medicine Communications 37(2): 116-121

The aim of this study was to evaluate, using PET/computed tomography (CT), changes in liver metabolic activity in patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT). A total of 29 biopsy-proven LARC patients between 2009 and 2012 were studied. Liver standardized uptake values (SUVs) and SUVs adjusted for lean body mass (SULs) were obtained from PET/CT images obtained at 1 h (early) and 2 h (late) after (18)F-fluorodeoxyglucose ((18)F-FDG) administration both before and after neoadjuvant CRT. Age, sex, BMI, lean body mass, blood glucose level, and (18)F-FDG dose, which can influence liver SUVs and SULs, were also analyzed. Fourteen (48%) men and 15 (52%) women with a mean age of 62±11 years (range 34-80 years) were included in the study. The mean SUVs and SULs were significantly decreased in the late scans. Sex was significantly correlated with the mean liver SUV in early and late scans. The mean SUV differed significantly between male and female patients in early and late images (P<0.05). In a multivariate stepwise regression analysis, only liver SUVs (maximum and mean) were significantly associated with BMI before and after therapy. SUVs were significantly higher in the high (≥25) BMI group after but not before therapy. Mean SUL was not influenced by BMI. Liver (18)F-FDG uptake is consistent before and after neoadjuvant CRT therapy in patients with LARC. When assessing response to therapy and using liver metabolic activity to indicate background activity, BMI should be considered as it can influence liver metabolic activity.


PMID: 26440564

DOI: 10.1097/MNM.0000000000000412

Other references

Adam, M.; Erkan, A.Nabi.; Arslan, D.; Leblebici, B.; Ozlüoğlu, L.; Nafiz Akman, M., 2007: High-frequency sensorineural hearing loss in patients with ankylosing spondylitis: is it an extrarticuler feature of disease?. Objective The aim of this study was to investigate the ear involvement, especially at extended higher frequencies than those previously studied, in patients with ankylosing spondylitis (AS).Patients and methods We prospectively evaluated 45 consec...

Kim, B.Hyun.; Yu, N.; Kim, H.Ryoun.; Yun, K.Wook.; Lim, I.Seok.; Kim, T.Hyoung.; Lee, M-Kyung., 2015: Evaluation of the optimal neutrophil gelatinase-associated lipocalin value as a screening biomarker for urinary tract infections in children. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker in the detection of kidney injury. Early diagnosis of urinary tract infection (UTI), one of the most common infections in children, is important in order to avert long-term...

Maggi I.; Ottone C., 2003: Spatial-temporal precipitation analysis in the area between Scrivia T. and Nure T. (northern Italy). Monthly and annual precipitation data (1921-90) from 99 rain gauges, distributed over the study area, were used to set up a framework of the total precipitation and to calculate the index of pluviovariability spatial-temporal distribution. The ind...

Micheal, G., 1963: Effect of manuring on protein quality and protein fractions of food plants. With green organs, as the leaves of vegetable or fodder plants, nitrogen increases yields and protein content. Physiologically, the supply of N will serve to prevent an over-accelerated N mobilization, viz. an over-accelerated ageing of the leaves...

Sparrow, F.K., 1978: 2 neustonic fungi. Two chytridiaceous fungi were found in the neuston of a Florida [USA] lake. Both parasitized living pine pollen grains dropped in the water. Phlyctochytrium macrosporum sp. nov. was characterized by having apophysate sporangia bearing 1 or more he...

Sabirov, S., 1984: Composition of the walls of nocardial-like versions of Streptomyces tumemacerans and Streptomyces albus var. fungatus cultures. Uzbekskii biologicheskii zhurnal: ) 62

Schwartz, R.A., 1997: Glucagonoma and pseudoglucagonoma syndromes. International Journal of Dermatology 36(2): 81-89

Red, 2015: Better lung function thanks to fixed combination. Mmw Fortschritte der Medizin 157(7): 72-72

Shapiro, L.M., 1982: Facial neurinoma. Vestnik Otorinolaringologii: 71-72

Phillips, B.E.; Giannoukakis, N., 2011: Drug delivery technologies for autoimmune disease. Targeting autoimmune disease poses two main challenges. The first is to identify unique targets to suppress directly or indirectly autoreactive cells exclusively. The second is to penetrate target tissues to deliver specifically drugs to desired c...