+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-Term Multifunctional Outcome and Risks of Face Vascularized Composite Allotransplantation

, : Long-Term Multifunctional Outcome and Risks of Face Vascularized Composite Allotransplantation. Journal of Craniofacial Surgery 26(7): 2038-2046

Vascularized composite allotransplantation (VCA) to reconstruct complex centrally located facial defects and to restore vital functions in a 1-staged procedure has worldwide gained acceptance. Continuous long-term multidisciplinary follow-up of face transplant patients is mandatory for surveillance of the complications associated with the immunosuppressive regime and for functional assessment of the graft. In December 2011, our multidisciplinary team performed a digitally planned face transplant at the Ghent University Hospital, Belgium on a 55-year-old man with a large central facial defect after a high-energy ballistic injury. The patient was closely followed to assess functional recovery, immunosuppressive complications, overall well-being, and quality of life. Three years postoperatively, the patient and his family are very satisfied with the overall outcome, and social reintegration in the community is successful. Motor and sensory functions have recovered near normal. Infectious and medical complications have been serious but successfully managed. Immunosuppressive maintenance therapy consists of corticoids, tacrolimus, and mycophenolate mofetil in minimal doses. Epithetic reconstruction of both eyes gave a tremendous improvement on the overall aesthetic outcome. Despite serious complications during the first 12 months, multifunctional outcome in the first face transplant in Belgium (#19 worldwide) is successful. This should be attributed to the continuous and long-term multidisciplinary team approach. As only few reports of other face transplant patients on long-term follow-up are available, more data need to be collected and reported to further outweigh the risk benefit ratio of this life changing surgery.


PMID: 26468783

DOI: 10.1097/SCS.0000000000002110

Other references

Ashoka, S.; Hegde, Y.R.; Srikant Kulkarni, 2007: Interaction between fungal pathogens in Vanilla planifolia under shade net condition. An experiment was conducted to determine the interaction of the host (Vanilla planifolia) with isolated pathogens, i.e. Colletotrichum gloeosporioides [Glomerella cingulata], Fusarium oxysporum, Sclerotium rolfsii [Corticium rolfsii] and Rhizocton...

Kurova, N.S.; Cheremushkin, E.A., 1999: Spectral characteristics of EEG during formation a set to illusory length perception (Müller-Lyer illusion). A cognitive set to illusory perception of linear relationships was formed in 56 young healthy subjects. After 10 presentations of Müller-Lyer figures, 39 subjects formed the stable set. In 17 subjects the unstable set was formed. The spectral pow...

Singh, K.N.rang, R., 1971: Influence of the timings of first irrigation on the performance of high yielding wheat strains & their water use pattern. Indian journal of agronomy: 16 (3) 366-367

Taga, G.; Watanabe, H.; Homae, F., 2012: Spatiotemporal properties of cortical haemodynamic response to auditory stimuli in sleeping infants revealed by multi-channel near-infrared spectroscopy. Multi-channel near-infrared spectroscopy (NIRS) has been used as a neuroimaging tool to study functional activation of the developing brain in infants. In this paper, we focus on spatiotemporal dynamics of cortical oxygenation changes during senso...

Campbell, J.; Rashid, W.; Cercignani, M.; Langdon, D., 2016: Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life. To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple sclerosis (BIC...

Delorenzo, F.; Illiano, G.; Molea, G.; Dellapietra, G., 1964: Effect Of Beta-Methylaspartate On Ornithine Cycle Reactions. Nature 201: 1129-1129

Loveday, K.S.; Lugo, M.H.; Resnick, M.A.; Anderson, B.E.; Zeiger, E., 1989: Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. Twenty chemicals were tested for their ability to induce sister chromatid exchanges (SCEs) and chromosomal aberrations (ABs) in cultured Chinese hamster ovary cells (CHO). These chemicals were tested with and without an added metabolic activation...

Doroszewski, A.; Gorska, K.; Krakowiak, A., 1991: The influence of irradiation reflected from artificial surfaces on buckwheat plant growth habit. In pot trials in 1990, buckwheat cv. Emka was sown on 15 May and cv. KN1 on 13 July. Pots were kept outside during the day and placed just south of perpendicular wooden plates (140 X 60 cm) differing in spectral reflectance. The plates were covere...

Van Valkenburgh, B.; Teaford, M.F.; Walker, A., 1990: Molar microwear and diet in large carnivores: inferences concerning diet in the sabretooth cat, Smilodon fatalis. Patterns of dental microwear provide some of the best indirect evidence of tooth use and diet in living and extinct species, and thus can supplement inferences based on gross morphology. In this paper, dental microwear features are examined in the...

Burgel, P-R., 2010: Physical activity and cystic fibrosis. Revue des Maladies Respiratoires 27(4): 287-288