geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders


, : Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders. Journal of Affective Disorders 178(): 71-78

Long-term symptomatic status in persons with major depressive and bipolar disorders treated clinically is not well established, although mood disorders are leading causes of disability worldwide. To pool data on long-term morbidity, by type and as a proportion of time-at-risk, based on published studies and previously unreported data. We carried out systematic, computerized literature searches for information on percentage of time in specific morbid states in persons treated clinically and diagnosed with recurrent major depressive or bipolar I or II disorders, and incorporated new data from one of our centers. We analyzed data from 25 samples involving 2479 unipolar depressive and 3936 bipolar disorder subjects (total N=6415) treated clinically for 9.4 years. Proportions of time ill were surprisingly and similarly high across diagnoses: unipolar depressive (46.0%), bipolar I (43.7%), and bipolar II (43.2%) disorders, and morbidity was predominantly depressive: unipolar (100%), bipolar-II (81.2%), bipolar-I (69.6%). Percent-time-ill did not differ between UP and BD subjects, but declined significantly with longer exposure times. The findings indicate that depressive components of all major affective disorders accounted for 86% of the 43-46% of time in affective morbidity that occurred despite availability of effective treatments. These results encourage redoubled efforts to improve treatments for depression and adherence to their long-term use.

US$19.90

PMID: 25797049

DOI: 10.1016/j.jad.2015.02.011


Other references

Webb, R.; Campbell, B.K.; Garverick, H.A.; Gong, J.G.; Gutierrez, C.G.; Armstrong, D.G., 2000: Molecular mechanisms regulating follicular recruitment and selection. Ovarian follicular growth and development is an integrated process encompassing both extraovarian signals, such as gonadotrophins and metabolic hormones, and intraovarian factors. Follicular development has been classified into gonadotrophin-indep...

Wohlleben, W.; Stegmann, E.; Süssmuth, R.D., 2009: Chapter 18. Molecular genetic approaches to analyze glycopeptide biosynthesis. The glycopeptide antibiotics vancomycin and teicoplanin are used in the hospital as drugs of last resort to combat resistant Gram-positive pathogens, in particular methicillin-resistant Staphylococcus aureus. All glycopeptides consist of a heptape...

Schnettler, E.; Sterken, M.G.; Leung, J.Y.; Metz, S.W.; Geertsema, C.; Goldbach, R.W.; Vlak, J.M.; Kohl, A.; Khromykh, A.A.; Pijlman, G.P., 2013: Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells. West Nile virus (WNV) and dengue virus (DENV) are highly pathogenic, mosquito-borne flaviviruses (family Flaviviridae) that cause severe disease and death in humans. WNV and DENV actively replicate in mosquitoes and human hosts and thus encounter...

Ruthven Carol L.; Greb Stephen F., 1999: The Earth Science Education Network. GeoInfo

Robinson W.B., 1983: Computers in mining. The AusIMM Bulletin (1990): Pages 13-14. 1983.

Chernokozhev, K., 1973: 176 cases of prolonged general anesthesia. Khirurgiia 26(6): 562-566

Park, S.; Park, T.Sun.; Choi, C-Min.; Lee, D.Ho.; Kim, S-We.; Lee, J-Shin.; Kim, W.Sung.; Song, J.Seon.; Lee, J.Cheol., 2016: Survival Benefit of Pemetrexed in Lung Adenocarcinoma Patients With Anaplastic Lymphoma Kinase Gene Rearrangements. There have been conflicting findings regarding the efficacy of pemetrexed for lung cancer with anaplastic lymphoma kinase (ALK) rearrangement. This study was conducted to explore the benefits of pemetrexed in this patient group. Among patients who...

Vandezande, A.; Van Haver, W.; Gordts, L., 1977: Organochloride pesticide residues in various foodstuffs: meat and fish. Archives Belges de Medecine Sociale, Hygiene, Medecine du Travail et Medecine Legale. Belgisch Archief van Sociale Geneeskunde, Hygiene, Arbeidsgeneeskunde en Gerechtelijke Geneeskunde 35(4): 272-278

Woessner, R.D.; Loudy, D.E.; Wallace, C.D.; Montgomery, L.R.; Cross Doersen, D.E.; Bush, T.L.; Lewis, M.T.; Prakash, N.; Bitonti, A.J.; Wright, P.S., 1997: Decreased vascular endothelial growth factor expression associated with tumor regression induced by -2-deoxy-2- cytidine. The effect of the antitumor drug MDL 101,731 ((E)-2'-deoxy-2'-(fluoromethylene)cytidine) on tumor growth and on steady-state vascular endothelial growth factor (VEGF) mRNA levels in MDA-MB-231, PC-3, MCF-7, and HT-29 human tumor xenograf...

Agostoni, C.; Terracciano, L.; Varin, E.; Fiocchi, A., 2016: The Nutritional Value of Protein-hydrolyzed Formulae. Allergy to cow's milk proteins is a challenging condition in early infancy. Allergic infants may be predisposed to impairments of growth from either the disease itself or the nutritional constraints of the exclusion diet they should follow. F...