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Long-term sequelae treatment of peripheral facial paralysis with botulinum toxin type A: Repartition and kinetics of doses used


, : Long-term sequelae treatment of peripheral facial paralysis with botulinum toxin type A: Repartition and kinetics of doses used. Annales de Chirurgie Plastique et Esthetique 61(1): 10-15

Botulinum toxin is a key therapeutic tool in the comprehensive treatment of peripheral facial paralysis. It fights spasms, synkinesis and overactivity of the different skin muscles responsible of facial expressions. Even though injection techniques as well as target muscles have been well identified, doses used remain quite imprecise and often not detailed muscle by muscle, further more dosage progression has not been monitored over time. Our retrospective study is the first one to refine the repartition of botulinum toxin doses on each of the relevant skin muscles and assess dosage kinetics. Thirty patients were included since 2008 with a mean follow-up of 2.3years. Each patient had at least 3 injections, with a delay of 4 to 6months between each injection. Mean doses are indicated for each muscle injected on the paralyzed and healthy sides. Dose kinetics suggests an initial dosage increase after the first injection followed by a decrease over time. No treatment resistance was observed. Our study represents a didactic help in using botulinum toxin for sequelae of peripheral facial paralysis by providing more details on the effective mean doses for each muscle and their progression over time.

US$19.90

PMID: 25953657

DOI: 10.1016/j.anplas.2015.04.002


Other references

Roth M.G.; Compans R.W., 1981: Delayed appearance of pseudotypes between vesicular stomatitis virus and influenza virus during mixed infection of mdck cells. In intact Madin-Darby canine kidney (MDCK) cell monolayers, vesicular stomatitis virus (VSV) matures only at basolateral membranes beneath tight junctions; influenza virus buds from apical cell surfaces. Early in the growth cycle, the viral glycop...

Parashari, U.C.; Upadhyay, D.; Khanduri, S.; Qayyum, F.Akbar.; Bhadury, S., 2011: Primary renal hydatidosis with associated macroscopic hydatiduria--a computed tomography urography diagnosis with pathological confirmation. Primary renal hydatid disease which involves any other organ is extremely rare. Cystic rupture into the pelvicalyceal system, causing hydatiduria, is pathognomonic of renal hydatidosis, although it is usually microscopic and is seen in only 1&ndas...

Wolff, J.L.; Roter, D.L.; Barron, J.; Boyd, C.M.; Leff, B.; Finucane, T.E.; Gallo, J.J.; Rabins, P.V.; Roth, D.L.; Gitlin, L.N., 2014: A tool to strengthen the older patient-companion partnership in primary care: results from a pilot study. To determine the acceptability of a pre-consultation checklist for older adults who attend medical visits with an unpaid companion and to evaluate its effects on visit communication. Randomized controlled pilot study. Academic geriatrics ambulator...

Censky, E.J.; Hodge, K.; Dudley, J., 1998: Over-water dispersal of lizards due to hurricanes. Evidence to support over-water dispersal as the mechanism by which green iguanas colonized the Caribbean island of Anguilla is presented. For such dispersal to be considered realistic, it must be demonstrated that a viable population could be esta...

Deni, R., 1978: Social influences on operant behavior in japanese quail sex differences among subjects and sex and age differences among companions. Operant key pecking was assessed in adult male and female Japanese quail (Coturnix coturnix japonica) during visual exposure to a variety of companion conditions using within-subjects designs. Earlier findings with male quail were replicated, and...

Ren, Z.J.; Baumann, R.G.; Black, L.W., 1997: Cloning of linear DNAs in vivo by overexpressed T4 DNA ligase: Construction of a T4 phage hoc gene display vector. A method was developed to clone linear DNAs by overexpressing T4 phage DNA ligase in vivo, based upon recombination deficient E. coli derivatives that carry a plasmid containing an inducible T4 DNA ligase gene. Integration of this ligase-plasmid i...

Anonymous, 1991: Coffee, caffeine, and cardiovascular disease. New England Journal of Medicine 324(14): 991-992

Campbell L.D.; Papas A.; Cansfield P., 1977: Characterization of the effects of rapeseed glucosinolates on production thyroid status egg iodine and incidence of hemorrhagic liver in poultry. Canadian Journal of Animal Science 57(4): 846

McAlarney, B.P., 2008: Using telehealth technology to better treat TBI. Behavioral Healthcare 28(5): 38, 40-38, 40

Clack, J.A.; Carroll, R.L., 2000: Early Carboniferous tetrapods. Amphibian Biology, 4: 1030-1043