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Lorentz contact resonance spectroscopy for nanoscale characterisation of structural and mechanical properties of biological, dental and pharmaceutical materials

, : Lorentz contact resonance spectroscopy for nanoscale characterisation of structural and mechanical properties of biological, dental and pharmaceutical materials. Journal of Materials Science. Materials in Medicine 26(12): 272-272

Scanning probe microscopy has been widely used to obtain topographical information and to quantify nanostructural properties of different materials. Qualitative and quantitative imaging is of particular interest to study material-material interactions and map surface properties on a nanoscale (i.e. stiffness and viscoelastic properties). These data are essential for the development of new biomedical materials. Currently, there are limited options to map viscoelastic properties of materials at nanoscale and at high resolutions. Lorentz contact resonance (LCR) is an emerging technique, which allows mapping viscoelasticity of samples with stiffness ranging from a few hundred Pa up to several GPa. Here we demonstrate the applicability of LCR to probe and map the viscoelasticity and stiffness of 'soft' (biological sample: cell treated with nanodiamond), 'medium hard' (pharmaceutical sample: pMDI canister) and 'hard' (human teeth enamel) specimens. The results allowed the identification of nanodiamond on the cells and the qualitative assessment of its distribution based on its nanomechanical properties. It also enabled mapping of the mechanical properties of the cell to demonstrate variability of these characteristics in a single cell. Qualitative imaging of an enamel sample demonstrated variations of stiffness across the specimen and precise identification of enamel prisms (higher stiffness) and enamel interrods (lower stiffness). Similarly, mapping of the pMDI canister wall showed that drug particles were adsorbed to the wall. These particles showed differences in stiffness at nanoscale, which suggested variations in surface composition-multiphasic material. LCR technique emerges as a valuable tool for probing viscoelasticity of samples of varying stiffness's.


PMID: 26518012

DOI: 10.1007/s10856-015-5605-1

Other references

Hazel, A.L.; Friedman, M.H., 2001: Method for assessing the need for case-specific hemodynamics: application to the distribution of vascular permeability. A common approach to understanding the role of hemodynamics in atherogenesis is to seek relationships between parameters of the hemodynamic environment, and the distribution of tissue variables thought to be indicative of early disease. An importa...

Brasky, T.M.; Crowe, F.L.; Kristal, A.R., 2013: n-3 Fatty acids and prostate cancer risk. British Journal of Nutrition 108(9): 1721-1721

Gordon, R.; Chatfield, R.K., 1969: Pits in the optic disc associated with macular degeneration. British Journal of Ophthalmology 53(7): 481-489

Ricci, C.; Carradori, R.; Miele, A.; Patanè, E., 1987: Usefulness of the study of blood amylase in the diagnosis of atypical clinical pictures of endemic parotitis. Minerva Pediatrica 39(17-18): 697-699

Graves, J.; Leonard, B.; Burris, E.M.cinski, S., 1994: Status of insecticide resistance in tobacco budworm and bollworm in Louisiana. Proceedings (2): 769-774

Verre, R.; Svedendahl, M.; Odebo Länk, N.; Yang, Z.J.; Zengin, G.; Antosiewicz, T.J.; Käll, M., 2015: Directional Light Extinction and Emission in a Metasurface of Tilted Plasmonic Nanopillars. Plasmonic optical antennas and metamaterials with an ability to boost light-matter interactions for particular incidence or emission angles could find widespread use in solar harvesting, biophotonics, and in improving photon source performance at...

Burns, M.; Kearnan, J.; Biggers, J.U.ech, K., 1977: Dipping brahman crossbreds in South East Queenslanddoes it pay?. Queensland agricultural journal: 103 (6) 521-524

Stewart, J.G.; Baker, B.N.; Williams, T.P., 1977: Evidence for conformeric states of rhodopsin. Spectrophotometric measurements of metarhodopsin II appearance are made on five different kinds of rhodopsin preparations. Although the preparations differ greatly in their rhodopsin: phospholipid ratio, the meta II kinetics in all of them are str...

Liao Rusong, 1987: The application of stepwise discriminant analysis in predicting land collapse; the Guilin Karst region case. Carsologica Sinica: Pages 79-91. 1987.

Ahn, H.Y.l; Jung, J.Y.ung; Chang, Y.H.k; Kim, S.H.e; Kim, H.S.k; Chang, K.C.url, 1997: Genistein, inhibitor of tyrosine kinase, suppress Ca-2+ influx stimulated by high K+ and norepinephrine in rat aorta. Biophysical Journal 72(2 PART 2): A186