+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

, : Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma. Anticancer Research 36(10): 5499-5506

The cellular composition of the tumor microenvironment (TME) at the invading front of oral squamous cell carcinomas (OSCCs) may reflect biologically important cancer features and host responses, and thus be related to disease progression. The TME density of mast cells (MCs), macrophages, cancer-associated fibroblasts (CAFs) and endothelial cells were quantified at the invasive front and analyzed regarding their relation to disease recurrence in patients with small T1/2N0M0 OSCCs. mRNA for MC-specific proteins were analyzed in a second patient cohort with head and neck squamous cell carcinoma (HNSCC). Samples from 62 patients with T1/2N0M0 OSCC were immunohistochemically stained and scored for the cellular expression of mast/stem cell growth factor receptor (c-KIT) (MCs), CD68 (macrophages), α-smooth muscle actin (α-SMA) (CAFs) and CD31 (endothelial cells) and this was analyzed according to disease recurrence. Data from The Cancer Genome Atlas database were used to examine mRNA expression profiles and clinical data of patients with 399 HNSCC. Increased MC density at the invasive front was significantly associated with reduced disease recurrence, as none of the patients with high MC density experienced relapse. Moreover, increased expression of mRNA for MC specific markers as c-KIT, and α-, β-, and δ-tryptases and the MC-stimulating factor, stem cell factor (SCF), was significantly associated with good prognosis in patients with HNSCC. Decreased MC density at the invasive front may reflect tumor biology related to disease progression and prognosis. Counting MCs seems to be an easy and practical tool, that could be utilized for prognostic evaluation.


PMID: 27798921

Other references

Ostertag, S.K.; Tague, B.A.; Humphries, M.M.; Tittlemier, S.A.; Chan, H.Man., 2009: Estimated dietary exposure to fluorinated compounds from traditional foods among Inuit in Nunavut, Canada. Increasing evidence shows that persistent organic pollutants such as perfluorinated compounds (PFCs) are found in the Arctic ecosystem and their prevalence is causing human health concerns. The objective of this study was to estimate dietary expos...

Egri, C.; Vilin, Y.Y.; Ruben, P.C., 2012: A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation. A mutation in the β(1) subunit of the voltage-gated sodium (Na(V)) channel, β(1) (C121W), causes genetic epilepsy with febrile seizures plus (GEFS+), a pediatric syndrome in which febrile seizures are the predominant phenotype. Previous studies...

Webb, L.; Miles, K.; Kessler, F.; Ritter, J.K., 2006: Activity of rat UGT1A1 towards benzo[a]pyrene phenols and dihydrodiols. Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a]pyrene pyenols and dihydrodiols. UGTIA1 and UGTI1A7 were found to be broadly active towards BaP metabolites. Antisera recognizing rat UGT1A1 and U...

Zelina, V., 1986: Chamois in the Nizke Tatry National Park.. Ziva, 342: 75-76

Neber, H.; Steinbach, R., 1956: Experiences with tyrothricin in ambulant practice. Wiener Medizinische Wochenschrift 106(11): 271-271

Mills, R.; Lee, P., 2003: Surgical skills training in middle-ear surgery. Until recently the practice of otological procedures on cadaver temporal bones was a common occurrence in otolaryngology departments. The difficulty in acquiring specimens has led to alternative techniques which involve artificial and computer-aid...

Jawhari, S.; Bessette, B.; Hombourger, S.; Durand, K.; Lacroix, Aélie.; Labrousse, Fçois.; Jauberteau, M-Odile.; Ratinaud, M-Hélène.; Verdier, M., 2017: Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival. Glioblastoma multiform (GBM), the most common and aggressive primary brain tumor, is characterized by a high degree of hypoxia and resistance to therapy because of its adaptation capacities, including autophagy and growth factors signaling. In thi...

Potenza, L.; Calcabrini, C.; D.B.llis, R.; Mancini, U.; Cucchiarini, L.; Dachà, M., 2009: Effect of quercetin on oxidative nuclear and mitochondrial DNA damage. Quercetin is a well-investigated antioxidant known to protect cells against oxidative nuclear DNA damage. There is no knowledge regarding its effect on oxidative mitochondrial DNA damage. In this study we investigated the effect of quercetin on ox...

Schouppe, Karl, 1932: The State veterinary and farriery institution at Graz. Wiener Tierarztl Monatsschr 19(9-10): 257-269, 289-303

Mather, L.E.; Edwards, S.R., 2006: Chirality in anaesthesia--ropivacaine, ketamine and thiopentone. Drug chirality (molecular handedness) is a source of pharmacological differences between otherwise chemically identical molecules. Specific applications to the pharmacology of ropivacaine (single enantiomer), ketamine and thiopentone (both racemat...