+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lung Cancer Prognosis in Elderly Solid Organ Transplant Recipients

, : Lung Cancer Prognosis in Elderly Solid Organ Transplant Recipients. Transplantation 99(10): 2181-2189

Treatment-related immunosuppression in organ transplant recipients has been linked to increased incidence and risk of progression for several malignancies. Using a population-based cancer cohort, we evaluated whether organ transplantation was associated with worse prognosis in elderly patients with non-small cell lung cancer (NSCLC). Using the Surveillance, Epidemiology, and End Results Registry linked to Medicare claims, we identified 597 patients aged 65 years or older with NSCLC who had received organ transplants (kidney, liver, heart, or lung) before cancer diagnosis. These cases were compared to 114,410 untransplanted NSCLC patients. We compared overall survival (OS) by transplant status using Kaplan-Meier methods and Cox regression. To account for an increased risk of non-lung cancer death (competing risks) in transplant recipients, we used conditional probability function (CPF) analyses. Multiple CPF regression was used to evaluate lung cancer prognosis in organ transplant recipients while adjusting for confounders. Transplant recipients presented with earlier stage lung cancer (P = 0.002) and were more likely to have squamous cell carcinoma (P = 0.02). Cox regression analyses showed that having received a non-lung organ transplant was associated with poorer OS (P < 0.05), whereas lung transplantation was associated with no difference in prognosis. After accounting for competing risks of death using CPF regression, no differences in cancer-specific survival were noted between non-lung transplant recipients and nontransplant patients. Non-lung solid organ transplant recipients who developed NSCLC had worse OS than nontransplant recipients due to competing risks of death. Lung cancer-specific survival analyses suggest that NSCLC tumor behavior may be similar in these 2 groups.


PMID: 25839704

DOI: 10.1097/TP.0000000000000715

Other references

Jamal, Q.; Jafarey, N.A.; Naqvi, A.J., 1988: A review of 1508 percutaneous renal biopsies. Jpma. Journal of the Pakistan Medical Association 38(10): 272-275

Alexander, J.K.; Peterson, K.L., 1968: Nutritional factors in cardiovascular disease. Postgraduate Medicine 44(3): 167-171

Marian Yallop; Heike Hirst; Martyn Kelly; Steve Juggins; Jane Jamieson; Robin Guthrie, 2009: Validation of ecological status concepts in UK rivers using historic diatom samples. We assessed the feasibility of using herbarium specimens to validate reference conditions in the UK by comparing diatom community composition of river sites with both recent and historic diatom samples. The question of substrate specificity was ad...

Langosch, J.M.; Zhou, X.Y.; Heinen, M.; Chatterjee, S.S.; Nöldner, M.; Walden, J., 2001: Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices. Therapeutic uses of Hypericum extracts have been demonstrated as safe and effective in treating mild to moderate depression in numerous clinical trials. To date, however, no definitive statements on their mode of action can be made, and little inf...

Bremekamp, C.E.B., 1956: The concepts on which a morphology of the vascular plants should be based. Start-ing from the principle that the rank of a morphological part is determined by the rank of the taxonomic group for which it is characteristic, it is argued that both in sporophyte and game-tophyte of the vascular plants in the first place a v...

Bormann, C.L.; Swain, J.E.; Clifford, A.L.; Gourley, D.D.; Krisher, R.L., 2001: Effect of recipient oocyte metabolism on development of ovine nuclear transfer embryos. Biology of Reproduction 64(Supplement 1): 143

Matczak, J., 1972: Epidemiology of emergencies posing threat to life in the City of Lódź. Polski Tygodnik Lekarski 27(9): 353-355

Staub, A., 2006: A blind mother. Kinderkrankenschwester 25(11): 461-462

Zhao, Y.; Chen, N.; Mo, Y.; Cao, Z., 2015: A full picture of enzymatic catalysis by hydroxynitrile lyases from Hevea brasiliensis: protonation dependent reaction steps and residue-gated movement of the substrate and the product. Hydroxynitrile lyases (HNLs) defend plants from herbivores and microbial attack by releasing cyanide from hydroxynitriles. The reverse process has been productively applied to bioorganic syntheses of pharmaceuticals and agrochemicals. To improve o...

Diewitz, M., 1998: (Incipient) paradigm change in cardiology?. Versicherungsmedizin 50(4): 154-154