geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?


, : MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases 33(1): 41-50

Several comparable mechanisms have been identified for hepatic and pulmonary fibrosis. The human microfibrillar associated glycoprotein 4 (MFAP4), produced by activated myofibroblasts, is a ubiquitous protein playing a potential role in extracellular matrix (ECM) turnover and was recently identified as biomarker for hepatic fibrosis in hepatitis C patients. The current study aimed to evaluate serum levels of MFAP4 in patients with pulmonary fibrosis in order to test its potential as biomarker in clinical practice. A further aim was to determine whether MFAP4 deficiency in mice affects the formation of pulmonary fibrosis in the bleomycin model of lung fibrosis. 91 patients with idiopathic pulmonary fibrosis (IPF), 23 with hypersensitivity pneumonitis (HP) and 31 healthy subjects were studied. In the mouse model, C57BL/6 Mfap4+/+ and Mfap4-/- mice between 6-8 weeks of age were studied. Serum levels of MFAP4 were measured by ELISA in patients and in mice. Surfactant protein D (SP-D) and LDH were measured as comparison biomarkers in patients with pulmonary fibrosis. Morphometric assessment and the Sircol kit were used to determine the amount of collagen in the lung tissue in the mouse model. Serum levels of MFAP4 were not elevated in lung fibrosis - neither in the patients with IPF or HP nor in the animal model. Furthermore no significant correlations with pulmonary function tests of IPF patients could be found for MFAP4. MFAP4 levels were increased in BAL of bleomycin treated mice with pulmonary fibrosis. MFAP4 is not elevated in sera of patients with pulmonary fibrosis or bleomycin treated mice with pulmonary fibrosis. This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis.

US$29.90

PMID: 27055835


Other references

Nirwan, R.S.; Ram, G.; Upadhaya, J., 1972: Chemical control of turmeric leaf spot incited by Taphrina maculans, Butler. Zineb at 0.2% controlled leaf spot and was superior to 5 other products tested, including copper compounds and antibiotics.

Nasir Y.J., 1986: Pollen morphological studies in the androsace primulaceae species found in pakistan. A total of 22 species of Androsace occurring in Pakistan have been studied for their pollen morphology. Although the pollen shows uniformity in shape, the pollen breadth and colpi length have been found useful at the sectional level of the genus....

Oshima, T.; Moriya, T., 2008: A preliminary analysis of microbial and biochemical properties of high-temperature compost. We investigated the microbial community of a high-temperature compost process exhibiting an internal temperature exceeding 90 degrees C. The waste pile was crosscut and samples were collected from the bottom to the top of the refuse pile. PCR-dena...

Nguyen, P.L.; Swanson, P.E.; Jaszcz, W.; Aeppli, D.M.; Zhang, G.; Singleton, T.P.; Ward, S.; Dykoski, D.; Harvey, J.; Niehans, G.A., 1994: Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis. Epidermal growth factor receptor (EGFR) immunoreactivity was evaluated in 85 cases of invasive transitional cell carcinoma of the bladder. The impact of EGFR staining on patient survival was compared with tumor stage, histologic grade, immunoreact...

Sano, T., 1983: A study on perifocal stroma in cervical cancer--significance of cellular infiltration and fibrous alteration. Nihon Gan Chiryo Gakkai Shi 18(1): 82-91

Putilina N.G.; Kulagin P.P.; Burkin V.S.; Ibragimov F.Kh, 1982: Immunological characteristics of surface water soluble yersinia enterocolitica antigens. The extraction of acetone-dried bacteria by means of tris-glycine buffer yielded the greatest number of antigens. Up to 16 antigenic components with different electrophoretic mobilities were revealed in Y. enterocolitica. Four thermostable protein...

Soares,E.B.; Gomes,R.L.F.; Campelo,J.E.G.; Lopes,A.C.deA.; MatosFilho,C.H.A., 2008: Repeatability and correlations among yellow mombim morphoagronomical traits. The coefficient of repeatability in fourteen yellow mombin (<i>Spondias mombin</i>) in Teresina, Piaui State, Brazil, was estimated using the variance analysis method to determine the number of measures necessary for an accurate predic...

Lebedev, V.A.; Sakhno, V.G.; Yakushev, A.I., 2010: Total duration and spatial migration of Quaternary volcanism in the Elbrus region, Greater Caucasus. Doklady Earth Sciences 430.1

Montegut, J.; Jauzein, P., 1979: The morphology of Angiosperm seedlings. Systematic and ecophysiological considerations. The developmental morphology of a wide range of weed seedlings was examined. The results indicate the need for integrated study among various morphological, physiological, ecological and phytogeographical as well as taxonomic disciplines.

Kozlov, V.A.; Kovalev, V.A.; Darenkov, A.F., 1994: A method for revascularizing the penis. The authors propose an original method of vasculogenic impotence surgery involving correction of arterial and arteriovenous insufficiency of the penis. This includes isolation of penile dorsal artery and deep dorsal vein in the proximal and middle...