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Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with Glaucoma

, : Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with Glaucoma. Plos One 10(6): E0130175-E0130175

To examine microcystic inner nuclear layer (INL) changes in glaucomatous eyes and to determine associated factors. Retrospective, cross-sectional, observational study. Two hundred seventeen eyes of 133 patients with primary open angle glaucoma (POAG), 41 eyes of 32 patients with preperimetric glaucoma and 181 normal eyes of 117 subjects were ultimately included. Microcystic INL lesions were examined with infrared fundus images and with 19 vertical spectral domain optical coherence tomography (SD-OCT) images in the macular area. Microcystic INL changes were observed in 6.0% of eyes with POAG, but none of the normal eyes or eyes with preperimetric glaucoma showed microcystic INL changes. The proportion of eyes with advanced glaucoma was significantly larger (P = 0.013) in eyes with microcystic lesions than without. The visual field mean deviation (MD) slope was also significantly worse (P = 0.027) in eyes with microcystic lesions. No significant differences were observed in age, sex, refraction, axial length, intraocular pressure, or MD value between eyes with and without microcystic INL lesions. In several cases, microcystic INL lesions occurred along with glaucomatous visual field progression. The retinal nerve fiber layer (RNFL) thickness (P = 0.013) and ganglion cell layer (GCL) + inner plexiform layer thickness (P = 0.023) were significantly lower in areas with microcystic lesions than without. The INL was also significantly thicker (P = 0.002) in areas with microcystic lesions. Microcystic INL lesions in glaucomatous eyes are closely associated with RNFL and GCL thinning and correlated with worse MD slope. These INL lesions may indicate focal and progressive damage in glaucoma.


PMID: 26066021

DOI: 10.1371/journal.pone.0130175

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Gopi, P.G.; Subramani, R.; Narayanan, P.R., 2006: Trend in the prevalence of TB infection and ARTI after implementation of a DOTS programme in south India. To estimate the risk of tuberculosis (TB) infection among children <10 years and assess the impact of a DOTS-based programme. After DOTS implementation in Tiruvallur district, south India, we undertook three tuberculin surveys and estimated the...

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Selby, T., 1990: RN supply still below demand. American Nurse 22(3): 1, 10-1, 10

Langlois, X.; El-Mestikawy, S.; Arpin, M.; Triller, A.; Hamon, M.; Darmon, M., 1996: Differential addressing of 5-HT-1A and 5-HT-1B receptors in transfected LLC-PK1 epithelial cells: A model of receptor targeting in neurons. Based on the finding that the mechanism of membrane protein sorting may be similar in neurons and epithelial cells, we have investigated the localization of the 5-hydroxytryptamine-1A and 5-hydroxytryptamine-1B receptors in Eli Lilly and Company c...

Smith, W.J., 1993: Antibiotics in feed, with special reference to pigs: A veterinary viewpoint. The historical background of the present UK legislation is briefly reviewed, and the current legal situation as it pertains to the UK and European Community is summarized. The reasons for the inclusion of antibiotics in feed are outlined and discu...

Klima, R.; Rieder, H., 1955: Clinical observations on the interaction of tuberculosis and blood marrow diseases. Wiener Medizinische Wochenschrift 105(38-39): 779-783

Tsien, R.Y., 1986: New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations. Society of General Physiologists Series 40: 327-345

Ige, O.; Edem, V.F.; Arinola, O.G., 2016: Plasma Adenosine Deaminase Enzyme Reduces with Treatment of Pulmonary Tuberculosis in Nigerian Patients: Indication for Diagnosis and Treatment Monitoring. Tuberculosis(TB)-specific host biomarkers for diagnosis and monitoring of treatment response have been identified as priorities for TB research. Macrophage and T cell lymphocytes play vital roles in Mycobacterium tuberculosis immune response and t...

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Weiss, L., 1990: Comments on 'In vivo selection of human renal carcinoma cells with high metastatic potenital in nude mice'. Clinical & Experimental Metastasis 8(1): 103-109