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Mindfulness Meditation Modulates Pain Through Endogenous Opioids


, : Mindfulness Meditation Modulates Pain Through Endogenous Opioids. American Journal of Medicine 129(7): 755-758

Recent evidence supports the beneficial effects of mindfulness meditation on pain. However, the neural mechanisms underlying this effect remain poorly understood. We used an opioid blocker to examine whether mindfulness meditation-induced analgesia involves endogenous opioids. Fifteen healthy experienced mindfulness meditation practitioners participated in a double-blind, randomized, placebo-controlled, crossover study. Participants rated the pain and unpleasantness of a cold stimulus prior to and after a mindfulness meditation session. Participants were then randomized to receive either intravenous naloxone or saline, after which they meditated again, and rated the same stimulus. A (3) × (2) repeated-measurements analysis of variance revealed a significant time effect for pain and unpleasantness scores (both P <.001) as well as a significant condition effect for pain and unpleasantness (both P <.2). Post hoc comparisons revealed that pain and unpleasantness scores were significantly reduced after natural mindfulness meditation and after placebo, but not after naloxone. Furthermore, there was a positive correlation between the pain scores following naloxone vs placebo and participants' mindfulness meditation experience. These findings show, for the first time, that meditation involves endogenous opioid pathways, mediating its analgesic effect and growing resilient with increasing practice to external suggestion. This finding could hold promising therapeutic implications and further elucidate the fine mechanisms involved in human pain modulation.

US$19.90

PMID: 27039954

DOI: 10.1016/j.amjmed.2016.03.002


Other references

Pugliese, P.; Molto, J.C.; Damiani, P.; Marin, R.; Cossignani, L.; Manes J., 2004: Gas chromatographic evaluation of pesticide residue contents in nectarines after non-toxic washing treatments. Washing with aqueous solutions of citric acid, ethanol, glycerol, hydrogen peroxide, potassium permanganate, sodium metabisulfite, sodium laurylsulfate (SLS), sodium hypochlorite, and urea is evaluated for pesticide residue reduction in nectarines...

Lima, M.Alzete.de.; Pagliuca, L.Marlena.Freitag.; Nascimento, J.Cândido.do.; Caetano, J.Áfio., 2017: Comparing Interrater reliability between eye examination and eye self-examination 1. to compare Interrater reliability concerning two eye assessment methods. quasi-experimental study conducted with 324 college students including eye self-examination and eye assessment performed by the researchers in a public university. Kappa coef...

Davies, P.A., 1969: Feeding the newborn baby. Proceedings of the Nutrition Society 28(1): 66-72

Akimov, N.P.; Rentería, Ré.C., 2012: Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes. Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we...

Bonsembiante M.; Parigi Bini R., 1972: Nutritional requirements and nutritional levels in turkey production. Alimentazione Animale 16(3): 49-58

Zitouni, M.; Masson Pevetm, M.; Gauer, F.; Pevet, P., 1995: Influence of maternal melatonin on melatonin receptors in rat offspring. Using quantitative autoradiography, we have studied the influence of maternal plasma melatonin on the expression and density of melatonin receptors in the brain and pituitary of rat offspring. At birth, the same structures displayed melatonin rece...

Kaimer, S., 2007: Experiences with real free flow heat exchangers in the cane sugar industry. With reference to a case study at the South Louisiana Sugar Cooperative's sugar factory in St. James, this paper describes and discusses the merits of GEA Ecoflex's free flow heat exchangers.

Tsai, C-Hung.; Chuang, B-Kun.; Lan, Y-Li., 2010: The development and effectiveness of telecare from an integrated technological, humanistic and management perspective. A decreasing birthrate coupled with a growing elderly population has lead to an increased focus on elderly-centric issues such as long-term care and senior healthcare. Recent advances in information, communication and biomedical technologies have...

Demange, J.M., 1969: Materiaux pour servir d fine revision desHarpagophoridae. 6. Les Harpagophoridae decrits par F. Silvestri et conserves de l'Institut Filippo Silvestri (Portici, Italie). Boll. Lab, Ent. agr. Filippo Silvestri, 27: 253-286

Gabel, S., 2012: The medical director and the use of power: limits, challenges and opportunities. The organizational leadership in mental health agencies frequently resides in executives who are not psychiatrists and who may or may not have clinical backgrounds. Psychiatrists who are medical directors (MDs) of organizations with this structure...