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Mitochondria promote septin assembly into cages that entrap Shigella for autophagy


, : Mitochondria promote septin assembly into cages that entrap Shigella for autophagy. Autophagy (): 0-0

NlmCategory="UNASSIGNED">Septins are cytoskeletal proteins implicated in cytokinesis and host-pathogen interactions. During macroautophagy/autophagy of Shigella flexneri, septins assemble into cage-like structures to entrap actin-polymerizing bacteria and restrict their dissemination. How septins assemble to entrap bacteria is not fully known. We discovered that mitochondria support septin cage assembly to promote autophagy of Shigella. Consistent with roles for the cytoskeleton in mitochondrial dynamics, we showed that DNM1L/DRP1 (dynamin 1 like) can interact with septins to enhance mitochondrial fission. Remarkably, Shigella fragment mitochondria and escape from septin cage entrapment in order to avoid autophagy. These results uncover a close relationship between mitochondria and septin assembly, and identify a new role for mitochondria in bacterial autophagy.

US$19.90

PMID: 27629779

DOI: 10.1080/15548627.2016.1228496


Other references

Berberoglu, H., 1982: Use of the potential cost control method for food and beverage. Practice of hospitality management: 5-98

Chen, B.D.; Lin, H.S., 1984: Colony-stimulating factor (CSF-1): its enhancement of plasminogen activator production and inhibition of cell growth in a mouse macrophage cell line. CSF-1 is a hemopoietic growth factor that specifically causes the proliferation and differentiation of mononuclear phagocytic cells. J774 cells are a monocyte precursor-like macrophage cell line. This transformed macrophage cell line exhibits spec...

Chawla, S.; Chen, Y.; Katz, A.W.; Muhs, A.G.; Philip, A.; Okunieff, P.; Milano, M.T., 2009: Stereotactic body radiotherapy for treatment of adrenal metastases. To investigate the dosimetry and outcomes of patients undergoing stereotactic body radiotherapy (SBRT) for metastases to the adrenal glands. At the University of Rochester, patients have been undergoing SBRT for limited metastases since 2001. We r...

Giannitrapani, L.; Soresi, M.; Bondì, M.Luisa.; Montalto, G.; Cervello, M., 2015: Nanotechnology applications for the therapy of liver fibrosis. Chronic liver diseases represent a major global health problem both for their high prevalence worldwide and, in the more advanced stages, for the limited available curative treatment options. In fact, when lesions of different etiologies chronical...

Shameem, K.M.; Prathapan, K.D., 2014: A new species of Chaeridiona Baly (Coleoptera: Chrysomelidae: Cassidinae: Oncocephalini) infesting ginger Zingiber officinale Roscoe) and turmeric (Curcuma longa L.) in India and redescription of Chaeridiona pseudometallica Basu. Chaeridiona mayuri n. sp. infesting ginger (Zingiber officinale Roscoe) and turmeric (Curcuma longa L.) in southern India is described and illustrated. Cheilocostus speciosus ( J. Koenig) C. D. Specht, Globba sessiliflora Sims and Zingiber...

Yang, R.D.; Humphrey, A.E., 1975: Dynamic and steady state studies of phenol biodegradation in pure and mixed cultures. The microbial degradation of phenol by pure and mixed cultures of Pseudomonas putida was studied in batch, phenol-stat, and continuous culture systems. In the continuous culture runs, both steady state and transient experiments were performed. Fro...

Harris, W.S., 1973: Toxic effects of aerosol propellants on the heart. Archives of Internal Medicine 131(1): 162-166

Spudich, J.; Spudich, E.; Sasaki, J.; Jung, K.H.an; Perazzona, B.; Zhang, X.N.ng; Zhu, J., 1998: Activation of archaeal sensory rhodopsins and signal relay to their transducer proteins. Photochemistry & Photobiology 67(SPEC ISSUE): 86S-87S, June

Nagayama, N.; Masuda, K.; Takada, W.; Baba, M.; Hori, A.; Tamura, A.; Nagai, H.; Akagawa, S.; Kawabe, Y.; Machida, K.; Kurashima, A., 2001: The causes of death in patients with non-MDR pulmonary tuberculosis in our hospital. We studied the causes of death in 295 patients (mean (+/- SD) age 70.5 +/- 13.2 y.o.) with active non-MDR pulmonary tuberculosis who died in our hospital between 1991 and 1999. A hundred and twenty eight patients (43.4%, group A) died of tuberculo...

Dickinson, Fe, 1981: Limiting factors in saving wood in machine operations in sawmills. Holz als Roh und Werkstoff 39(4): 131-133