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Molecular pathways of human adrenocortical carcinoma - translating cell signalling knowledge into diagnostic and treatment options

, : Molecular pathways of human adrenocortical carcinoma - translating cell signalling knowledge into diagnostic and treatment options. Endokrynologia Polska 67(4): 427-450

Adrenocortical carcinoma is associated with a low cure rate and a high recurrence rate. The prognosis is poor, and at diagnosis 30-40% of cases are already metastatic. The current therapeutic options (surgical resection, followed by adjuvant mitotane treatment +/- chemotherapy) are limited, and the results remain unsatisfactory. Key molecular events that contribute to formation of adrenocortical cancer are IGF2 overexpression, TP53-inactivating mutations, and constitutive activation of the Wnt/b-catenin signalling pathway via activating mutations of the b-catenin gene. The underlying genetic causes of inherited tumour syndromes have provided insights into molecular pathogenesis. The increased occurrence of adrenocortical tumours in Li-Fraumeni and Beckwith-Wiedemann syndromes, and Carney complex, has highlighted the roles of specific susceptibility genes: TP53, IGF2, and PRKAR1A, respectively. Further studies have confirmed that these genes are also involved in sporadic tumour cases. Crucially, transcriptome-wide studies have determined the differences between malignant and benign adrenocortical tumours, providing potential diagnostic tools. In conclusion, enhancing our understanding of the molecular events of adrenocortical tumourigenesis, especially with regard to the signalling pathways that may be disrupted, will greatly contribute to improving a range of available diagnostic, prognostic, and treatment approaches. (Endokrynol Pol 2016; 67 (4): 427-440).


PMID: 27387247

DOI: 10.5603/EP.a2016.0054

Other references

Nizanski, W.; Klimowicz, M.; Dubiel, A., 2004: Wskazania i czynniki skutecznosci zabiegu oraz technika unasienniania dopochwowego suk. This paper presents indications and factors influencing the results of artificial insemination of bitches is performed if mating is impossible due to anatomical or behavioural causes, or the distance between the male and female. Preserved semen is...

Kang, J.; Nedergaard, M., 1997: Astrocyte-mediated long-term potentiation of inhibitory synaptic transmission in CA1 of hippocampus. Epilepsia 38(SUPPL 8): 18

Mancuso, A.; Derugin, N.; Ono, Y.; Hara, K.; Chen, S.F.; Sharp, F.R.; Weinstein, P.R., 1997: Correlation of HSP70 and c-fos m-RNA expression with regional depolarization determined by diffusion MRI following MCA occlusion in rats. Society for Neuroscience Abstracts 23(1-2): 1413

Halas, E.; Eberhardt, M., 1987: A behavioral review of trace element deficiencies in animals and humans. Trace elements in the diet have been found to be essential for the normal development of animals and humans. In animals, iron, zinc, copper, and manganese deficiencies early in life cause brain injury followed by various behavior deficits such as...

Raffa, P.; Wever, D.Armando.Zakarias.; Picchioni, F.; Broekhuis, A.A., 2015: Polymeric Surfactants: Synthesis, Properties, and Links to Applications. Chemical Reviews 115(16): 8504-8563

Kiang J.G., 1991: Effect of intracellular ph on cytosolic free calcium concentration in human epidermoid a 431 cells. This study characterizes the correlation between intracellular pH (pHi) and the cytosolic free Ca2+ concentration ([Ca2+]i) in suspended and adherent human epidermoid A-431 cells. Using the fluorescent dyes 2,7-bis(carboxyethyl)carboxyfluorescein...

Garner, P.; Kaniskan, H.Umit., 2005: Synthesis of highly functionalized pyrrolidines via a mild one-pot, three-component 1,3-dipolar cycloaddition process. [reaction: see text] A simple and efficient one-pot, three-component synthesis of highly functionalized pyrrolidines via cascade imine --> azomethine ylide --> 1,3-dipolar cycloadditions is reported. Admixing a variety of aldehydes, dimethyl...

Larochelle A., 1979: Lanthus parvulus odonata gomphidae natural history according to the literature. Cordulia 5(4): 82-83

Weber, B., 1974: Intensive care and resuscitation. Agressologie: Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees Aux Effets de L'agression 15(6): 359-362

Drnda, A.; Koluder, N.; Hadzic, A.; Bajramovic, N.; Baljic, R.; Mulabdic, V., 2009: Listeria meningoencephalitis in an immunocompetent person. Listeria monocytogenes is a small, aerobic or facultative anaerobic, non-sporulating gram positive bacillus that can be isolated from soil, vegetation or animal reservoirs. There are six species of Listeria, and only L. monocytogenes is pathogenic...