geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Monitoring nicotine intake from e-cigarettes: measurement of parent drug and metabolites in oral fluid and plasma


, : Monitoring nicotine intake from e-cigarettes: measurement of parent drug and metabolites in oral fluid and plasma. Clinical Chemistry and Laboratory Medicine (): -

Electronic cigarettes (e-cig) known as electronic nicotine devices recently gained popularity among smokers. Despite many studies investigating their safety and toxicity, few examined the delivery of e-cig-derived nicotine and its metabolites in alternative biological fluids. We performed a randomized, crossover, and controlled clinical trial in nine healthy smokers. Nicotine (NIC), cotinine (COT), and trans-3'-hydroxycotinine (3-HCOT) were measured in plasma and oral fluid by liquid chromatography-tandem mass spectrometry after consumption of two consecutive e-cig administrations or two consecutive tobacco cigarettes. NIC and its metabolites were detected both in oral fluid and plasma following both administration conditions. Concentrations in oral fluid resulted various orders of magnitude higher than those observed in plasma. Oral fluid concentration of tobacco cigarette and e-cig-derived NIC peaked at 15 min after each administration and ranged between 1.0 and 1396 μg/L and from 0.3 to 860 μg/L; those of COT between 52.8 and 110 μg/L and from 33.8 to 94.7 μg/L; and those of 3-HCOT between 12.4 and 23.5 μg/L and from 8.5 to 24.4 μg/L. The oral fluid to plasma concentration ratio of both e-cig- and tobacco cigarette-derived NIC peaked at 15 min after both administrations and correlated with oral fluid NIC concentration. The obtained results support the measurement of NIC and metabolites in oral fluid in the assessment of intake after e-cig use and appear to be a suitable alternative to plasma when monitoring nicotine delivery from e-cig for clinical and toxicological studies.

US$19.90

PMID: 27559692

DOI: 10.1515/cclm-2016-0405


Other references

Liu, H.; Zhang, J.; Han, Z-Yu.; Zhang, B-Song.; Zhang, W.; Qi, C-Sheng.; Yu, S-Yuan.; Li, H-Ze.; Su, H-Hui.; Duan, X-Min.; Li, Q-Ying.; Li, X-Mei.; Xu, R-Fang., 2016: Effectiveness of ultrasound-guided percutaneous microwave ablation for symptomatic uterine fibroids: a multicentre study in China. To evaluate the clinical efficacy of ultrasound-guided percutaneous microwave ablation (PMWA) therapy for symptomatic uterine fibroids in a multicentre study. Patients with symptomatic uterine fibroids who underwent PMWA at multiple treatment cent...

Bricker O.P., 1970: Mineral equilibria, disequilibria and reaction rates in nature. Abstracts with Programs - Geological Society of America 2(7): 502

Kivalo, E.; Talanti, S., 1962: On the hypothalamic-hypophyseal neurosecretory system of the camel and the seal. The hypothalamic-hypophyseal neurosecretory system of the camel, of the seal and of some laboratory and domestic animals were investigated by Gomori's chrome alum-hematoxylin and phloxine method as well as by his aldehyde-fuchsin method. In t...

Lee, E.S.; Chae, S.W.; Lim, H.H.; Hwang, S.J.; Suh, H.K., 2000: Clinical experiences with acute mastoiditis--1988 through 1998. The incidence of acute mastoiditis has declined dramatically during the postantibiotic era. Even so, antibiotic-resistant or unusual pathogens can still cause this disease entity. At our hospital, we documented an increase in antibiotic-resistant...

Anonymous, 1989: Dengue. Between December 1988 and April 1989, 38 565 cases of dengue fever were reported from the capital city district of Asuncion and 33 from Villarrica, Paraguay. No deaths were reported; all cases were of serotype 1.

Catanese, B.; Cioli, V.; D.M.rtino, C.; Silvestrini, B., 1978: A comparative study of serum and testicular concentrations of AF 1312/TS (or 1-[(4-chlorophenyl)methyl] 1H-indazole-3-carboxylic acid) and diclondazolic acid (or 1-[(2,4-dichlorophenyl)methyl)] -1H-indazole-3-carboxylic acid) in rats. Pharmacological Research Communications 10(3): 261-269

Faxon, D.P.; Schwamm, L.H.; Pasternak, R.C.; Peterson, E.D.; McNeil, B.Joyce.; Bufalino, V.; Yancy, C.W.; Brass, L.M.; Baker, D.W.; Bonow, R.O.; Smaha, L.A.; Jones, D.W.; Smith, S.C.; Ellrodt, G.; Allen, J.; Schwartz, S.J.; Fonarow, G.; Duncan, P.; Horton, K.; Smith, R.; Stranne, S.; Shine, K., 2004: Improving quality of care through disease management: principles and recommendations from the American Heart Association's Expert Panel on Disease Management. Previous laboratory investigations, case reports, and a hospital-based case-control study have suggested that marijuana use may be a risk factor for squamous cell head and neck cancer. We conducted a population-based case-control study to determin...

Meusinger, R., 2016: NMR hide-and-seek challenge. Analytical and Bioanalytical Chemistry 408(27): 7537-7541

Culp, W.T.N.; Glaiberman, C.B.; Pollard, R.E.; Wisner, E.R., 2015: Use of ethylene-vinyl alcohol copolymer as a liquid embolic agent to treat a peripheral arteriovenous malformation in a dog. An 11-year-old castrated male Tibetan Mastiff was evaluated because of a visibly enlarged blood vessel and progressively worsening swelling of the right hind limb. On physical examination, the right hind limb was markedly larger than the left hind...

Cassoly R., 1982: Interaction of hemo globin with the red blood cell membrane a saturation transfer epr study. Human Hb was labeled on cysteine 93(.beta.) with the maleimide spin label, 3-maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl, and reassociated with erythrocyte membrane previously stripped of Hb and glyceraldehyde-3-phosphate dehydrogenase. The a...