geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo


, : Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. European Journal of Pharmacology 783: 64-72

The therapeutic effectiveness of moracins as 2-arylbenzofuran derivatives against airway inflammation was examined. Moracin M, O, and R were isolated from the root barks of Morus alba, and they inhibited interleukin (IL)-6 production from IL-1β-treated lung epithelial cells (A549) at 101-00μM. Among them, moracin M showed the strongest inhibitory effect (IC50=8.1μM). Downregulation of IL-6 expression by moracin M was mediated by interrupting the c-Jun N-terminal kinase (JNK)/c-Jun pathway. Moracin derivatives inhibited inducible nitric oxide synthase (iNOS)-catalyzed NO production from lipopolysaccharide (LPS)-treated alveolar macrophages (MH-S) at 50-100μM. In particular, moracin M inhibited NO production by downregulating iNOS. When orally administered, moracin M (20-60mg/kg) showed comparable inhibitory action with dexamethasone (30mg/kg) against LPS-induced lung inflammation, acute lung injury, in mice with that of dexamethasone (30mg/kg). The action mechanism included interfering with the activation of nuclear transcription factor-κB in inflamed lungs. Therefore, it is concluded that moracin M inhibited airway inflammation in vitro and in vivo, and it has therapeutic potential for treating lung inflammatory disorders.

US$19.90

PMID: 27138708

DOI: 10.1016/j.ejphar.2016.04.055


Other references

Barattolo Filippo; Bigozzi Anna, 1996: Dasycladaleans and depositional environments of the Upper Triassic-Liassic carbonate platform of the Gran Sasso (Central Apennines, Italy). Facies: ages 163-208. 1996.

Braune, C.; Pohlemann, T.; Schandelmaier, P.; Tscherne, H., 1999: Osteonecrosis of the femoral head after osteosynthesis of a proximal femur fracture with a 95 degree condylar plate. Avascular necrosis of the femoral head is a frequent complication after osteosynthesis of femoral neck fractures. It is rarely seen after proximal femur fractures with intact trochanteric area. The choice of the implant varies from different blade...

Warwick, J.; Falaschetti, E.; Rockwood, K.; Mitnitski, A.; Thijs, L.; Beckett, N.; Bulpitt, C.; Peters, R., 2015: No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate in frailer older adults. To investig...

Khalid, Z.; Osuagwu, F.C.; Shah, B.; Roy, N.; Dillon, J.E.; Bradley, R., 2016: Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John's Wort. Celery root belongs to a group of plants classified as the umbelliferous family, which contains phytoestrogens. Phytoestrogens are structurally similar to estrogen as they share a pair of hydroxyl groups and phenolic ring, which enables them to bi...

Doucet, J., 1968: Un cas de nidification du Hibou des marais (Asio flammeus) dans l'Entre-Sambre-et-Meuse (1967). Aves, 5: 69-74

Chong, A.S.; Hersh, E.M.; Grimes, W.J., 1988: Blocking of lymphokine activated killer (LAK) cell mediated cytotoxicity by cell-sized beads bearing tumor cell proteins. Lymphokine activated killer cells (LAK) have been demonstrated to be cytotoxic for a variety of tumor-derived cells. Little is known of the nature of the cell surface molecules that mediate LAK cell-target cell interactions. Reported here are stud...

Mingari, M.-Cristina; Ponte, M.; Cantoni, C.; Vitale, C.; Schivetti, F.; Bertone, S.; Bellomo, R.; Cappai, A.-Tradori; Biassoni, R., 1997: HLA-class I-specific inhibitory receptors in human cytolytic T lymphocytes: Molecular characterization, distribution in lymphoid tissues and co-expression by individual T cells. A subset of cytolytic T lymphocytes has been shown to express receptors of the NK type (NKR) which can inhibit T cell cytotoxicity induced via the TCR-CD3 pathway. In this study, by the analysis of full length cDNA amplified from representative T...

Shimizu, H.; Takahashi, T.; Yamazaki, M.; Anzai, T.; Kudo, M.; Yozu, R., 2008: Extensive total arch replacement via clamshell incision in a patient with aortic arch aneurysm and Stanford type B aortic dissection. The utility of the clamshell approach, namely, a bilateral anterior thoracotomy incision for treating extensive thoracic aortic disease was described by Kouchoukos et al. in 2001 and by Doss et al. in 2003. We describe the utility of this approach...

Ishidate, T.; Yoshihara, S.; Kawasaki, Y.; Roy, B.C.andra; Toyoshima, K.; Akiyama, T., 1997: Identification of a novel nuclear localization signal in Sam68. Sam68, a nuclear RNA binding protein, binds to Src and is phosphorylated at tyrosine residues in an M-phase specific manner. Here we identified a stretch of 24 amino acid residues in the COOH-terminal portion of Sam68 which function as a nuclear l...

Kornilova A.Yu, 2000: Petrography and granulometry of sandstones of Tolparovskaya Formation Vendian deposits, Southern Urals. The most complete cross section of the Tolparovskaya Formation (stratotype) that is located within the Alatau Anticlinorium on the right bank of the Zilim River 1-1.5 km lower than the Tolparovo settlement was the object of study. Rocks have three...