+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mouse Models of Frailty: an Emerging Field

, : Mouse Models of Frailty: an Emerging Field. Current Osteoporosis Reports 13(5): 280-286

Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models can provide insight into molecular mechanisms of frailty by reducing variability in lifestyle and genetic factors that can complicate interpretation of human clinical data. Frailty, generally recognized as a syndrome involving reduced homeostatic reserve in response to physiologic challenges and increasing susceptibility to poor health outcomes, is predominantly assessed using two independent strategies, integrated phenotype and deficit accumulation. The integrated phenotype defines frailty by the presentation of factors affecting functional capacity such as weight loss, exhaustion, low activity levels, slow gait, and grip strength. The deficit accumulation paradigm draws parameters from a greater range of physiological systems, such as the ability to perform daily activities, coordination and gait, mental components, physiological problems, and history and presence of medical morbidities. This strategic division also applies within the emerging field of mouse frailty models, with both methodologies showing usefulness in providing insight into physiologic mechanisms and testing interventions. Our review will explore the strategies used, caveats in methodology, and future directions in the application of animal models for the study of the frailty syndrome.


PMID: 26243670

DOI: 10.1007/s11914-015-0283-y

Other references

Kresoja-Rakic, J.; Sulemani, M.; Kirschner, M.B.; Ronner, M.; Reid, G.; Kao, S.; Schwaller, B.; Weder, W.; Stahel, R.A.; Felley-Bosco, E., 2017: Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma. Calretinin (CALB2) is a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM). We previously reported that calretinin expression is regulated at the mRNA level. The presence of a medium-sized (573 nucleotide) 3' untranslate...

Matsumoto, S., 1976: Pathogenesis of hydrocephalus. Neurologia Medico-Chirurgica 16(3 Pt 2): 189-200

Januszko, T.; Zuch, A.; Buluk, K.; Bielecki, T., 1973: Release of plasminogen activator into blood and urine by rabbit's kidneys. Acta Haematologica Polonica 4(3): 223-230

Sproule, John, 1998: Running economy deteriorates following 60 min of exercise at 80 percent V02max. Fifteen young adult Singaporean male physical education students maximum oxygen consumption ((VO2max) = 56 (4.7) ml cntdot kg-1 cntdot min-1) performed three prolonged runs in a counterbalanced design. The running bouts varied in time (40 vs 60 mi...

Matsuhiro, B.Z.nlungo, A., 1980: Structural studies on the soluble polysaccharide of Chondrus canaliculatus. 1H-n.m.r. study of hexa-O-acetylcarrabiose dimethyl acetal. Carbohydrate research, 81(2): 335-340

Cleary, L.; Brennan, C., 2006: The influence of a (1 -> 3)(1 -> 4)-beta-D-glucan rich fraction from barley on the physico-chemical properties and in vitro reducing sugars release of durum wheat pasta. The effect of the addition of a beta-glucan fibre fraction from barley to durum wheat pasta was evaluated in terms of cooking characteristics, structure, texture and in vitro starch digestibility. Barley beta-glucan (BBG) fibre fraction was incorp...

Bezrukova, O.D.; Breusenko, V.G.; Shalina, R.I., 1986: Rheologic and coagulative properties of the blood in normal postmenopausal women and in those with endometrial pathology. Akusherstvo i Ginekologiia: 41-44

Ortiz, Santiago, 1999: Three new scapose species of Vernonia Schreb. (Asteraceae, Vernonieae) from Angola. Three new species from Angola are described: Vernonia lainzii, Vernonia longibracteata, and Vernonia platyseta (Asteraceae, Vernonieae). Morphological differences with putative related taxa are detailed and discussed. Vernonia lainzii is most simi...

Palm, G.J.; Wlodawer, A., 2003: Spectral variants of green fluorescent protein. Methods in Enzymology 302: 378-394

Varoquaux, P.S.rris, J., 1979: Spectrophotometric kinetics of o-diphenoloxidase in mushrooms (Agaricus bisporus). Lebensmittel Wissenschaft Technologie Food science technology 12(3): 165-168