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Myeloid-derived suppressor cells correlate with patient outcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma


, : Myeloid-derived suppressor cells correlate with patient outcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma. Cancer Immunology, ImmunoTherapy 65(6): 715-725

Hepatic arterial infusion chemotherapy (HAIC) has been employed as an alternative therapy to sorafenib for the patients with advanced hepatocellular carcinoma (HCC). In this study, we performed a comparative analysis of various immune cell responses including tumor-associated antigen (TAA)-specific T cells, regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in advanced HCC patients treated with HAIC. Thirty-six HCC patients were examined in the study. Interferon gamma enzyme-linked immunospot assays were performed to examine the frequency of TAA-specific T cells. The frequencies of Tregs and MDSCs were examined by multicolor fluorescence-activated cell sorting analysis. The treatment with HAIC using interferon (IFN)/5-fluorouracil (FU) or IFN/FU + cisplatin modulated the frequencies of various immune cells. In 22.2 % of patients, the frequency of TAA-specific T cells increased after HAIC. Although the frequency of Tregs decreased after HAIC, it was not associated with the prognosis of patients. An analysis of prognostic factors for overall survival identified diameter of the tumor (<3.0 cm), absence of major portal vein invasion, absence of distant metastasis, Union Internationale Contre Le Cancer tumor lymph node metastasis stage (I or II), neutrophil lymphocytic ratio (<2.1) and the frequency of MDSCs (<30.5 %) as factors that prolonged overall survival time after HAIC. Even in the group adjusted with progressive levels of tumors, patients with a low frequency of MDSCs had a significantly longer overall survival time. In conclusion, the frequency of MDSCs before the treatment is a prognostic factor in HAIC against HCC.

US$19.90

PMID: 27083166

DOI: 10.1007/s00262-016-1837-2


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Wenz, F.; Schneider, F.; Neumaier, C.; Kraus-Tiefenbacher, U.; Reis, T.; Schmidt, Ré.; Obertacke, U., 2010: Kypho-IORT--a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Instable and painful vertebral metastases in patients with progressive visceral metastases present a common therapeutic dilemma. We developed a novel approach to deliver intraoperative radiotherapy (IORT) during kyphoplasty and report the first tr...

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Thaman, O.P.; Manchanda, S.S., 1968: Child rearing practices in Punjab. Feeding practices and the related socio-economic factors were studied in 500 children aged between l month and 14 yr admitted to hospital in Amritsar. The diets of the mothers during pregnancy were poor, and included mostly wheat chappaties, lenti...

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Hwang YuanHsun; Chen ShuhChun, 1997: Effect of tonicity and additives to the fixative on ultrastructure of mesophyllous cells in Kandelia candel (L.) Druce (Rhizophoraceae). The effect was investigated of tonicity and additives in fixatives on the ultrastructure of mesophyllous cells of Kandelia candel. Nonionic additives such as sucrose were better than ionic additives such as NaCl, KCl, Na2SO4 or K2SO4. Measurement...

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Wang, Y.; Zhao, X.; Zhong, J.; Chen, Y.; Liu, X.; Wang, G., 2006: Simple determination of pirfenidone in rat plasma via high-performance liquid chromatography. A simple, rapid and reliable high-performance liquid chromatographic method was developed and validated for the determination of pirfenidone and its major metabolites in rat plasma. Plasma proteins were precipitated with perchloric acid (10%, v/v...