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Nanofabricated structures and microfluidic devices for bacteria: from techniques to biology

, : Nanofabricated structures and microfluidic devices for bacteria: from techniques to biology. Chemical Society Reviews 45(2): 268-280

Nanofabricated structures and microfluidic technologies are increasingly being used to study bacteria because of their precise spatial and temporal control. They have facilitated studying many long-standing questions regarding growth, chemotaxis and cell-fate switching, and opened up new areas such as probing the effect of boundary geometries on the subcellular structure and social behavior of bacteria. We review the use of nano/microfabricated structures that spatially separate bacteria for quantitative analyses and that provide topological constraints on their growth and chemical communications. These approaches are becoming modular and broadly applicable, and show a strong potential for dissecting the complex life of bacteria at various scales and engineering synthetic microbial societies.


PMID: 26383019

DOI: 10.1039/c5cs00514k

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