geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neurophysiological parameters in myasthena gravis in children in diagnostic and therapeutic view


, : Neurophysiological parameters in myasthena gravis in children in diagnostic and therapeutic view. Przeglad Lekarski 73(3): 119-123

Myasthenia gravis (MG) is an autoimmunologic disorder. It is characterized by various clinical symptoms and their dependency upon the exertion and the rest as well. Between 2002-20014 in the Neurophysiology Laboratory at the Chair of Pediatric and Adolescent Neurology, Jagiellonian University in Krakow, the electrophysiological repetitive nerve stimulation study were performed in 44 children. The clinical picture and positive electrophysiological test were the ground to diagnose MG in 19 of them (12 girls and 7 boys). The mean age at onset of MG in the examined group was 12.8 years. In 5 patients the diagnosis was completed using edrophonium test. In 14patients the titer of AchRAb was also tested. In 18 patients with MG the radiological examinations of the chest were performed. In 14/19 patients with MG the control electrophysiological testing was performed 2 to 8 months after the first one. The gen-ralized MG was diagnosed in 14 patients, and ocular in 2 of them. The amplitude of electro-physiological testing was normal during the first response in all patients, but the decrement of amplitude 4:1 in patients with MG was 26% to 88%. In 3 patients with MG the persisted thymus, while in 7 hypertrophy of thymus, in 2 thymoma nad inl thyinflammation of the thymus was detected. In 5 children the result of chest examination was normal. Among 5/8 patients (62.5%) with positive AChRAb, in one ocular MG was diagnosed, in the other 7 generalized MG. The titer of AChRAb was between 0.4 and 30.8 nmol/l (mean 9.44 nmol/l), and the decrement of amplitude 4:1 was 22% to 58%.. In the treatment pirydostygmine bromide (Mestinon) was used in all children, however in 4 of them together with azathioprine, and in 7 with steroids. In the treatment of myasthenic crisis in 5 patients plasmapheresis was performed. In 42% of patients thymectomy was performed during the first year after diagnosis. The clinical remission was succeed in 90,9% patients. The electrophysiological control examination detected the decrement of amplitude 4:1 in 1% to 80% (mean 36%). The electrophysiological remission, correlating with clinical remission was achieved in 2 patients. In 6/10 patients with clinical remission, the decrement of amplitude 4:1 in electrophysiological examination continued to be at the level similar to initial examination. In 1 patient remission was complete allowing significant reduction of doses of Mestinon, even though in the electrophysiological test the decrement was 80%. (1) Among hospitalized children, the generalized myasthenia was the most common. (2) Neurophysiological studies plays still fundamental role in diagnostic methods in the diagnosis of myasthenia gravis in children. (3) The correlation of the clinical state and electrophysiological results was not established.

US$29.90

PMID: 27349037


Other references

Minghetti, A., 1956: Thiopyrimidine inhibition of the growth of S faecalis Search for anomalous nucleic acid bases in the micro-organism. The possibility that 2 growth inhibitors,2-thio-cytosine and 5-bromo-cytosine, may be incorporated into nucleic acids of Streptococcus faecalis R (ATCC 8043), was investigated. S. faecalis was grown with 250 [mu]g of 2-thio-cytosine (labeled with...

Korot'ko, G.F.; Kadirov, S., 1996: Thyrotropin and thyroid hormones in human saliva before and after the taking of food. Saliva of parotid or submaxillary and sublingual glands and venous blood were collected using the Leshly-Krasnogorskiĭ's capsules in young men volunteers on an empty stomach immediately and in 30 minutes after meal. Contents of thyrothropin...

Ostrovskiy A.B., 1982: Paleogeographic criteria for the causes of Recent paleohydrologic regime changes of internal continental seas. Pages 102-112 1982

Oosterhuis, D.M.; Howard, D.D., 2008: Evaluation of slow-release nitrogen and potassium fertilizers for cotton production. Current nitrogen (N) and potassium (K) fertilization involves the use of conventional fertilizer materials with little information on the use of slow release materials. The objectives of this research were to evaluate new programmed slow-release N...

Dominiczak, M., 2009: Hyperlipidaemia and cardiovascular disease: nonlipid-lowering effects of omega-3 fatty acids, statins and fibrates. Current Opinion in Lipidology 20(1): 79-81

Papi, F., 1950: Ricerche cariologiche sui rabdoceli. i. Sopra alcuni rappresentanti della Fam. Typhloplanidae. Caryologia Pisa, 2: 113-126

Tyagi, N.; Narayana, V., 1980: Chance constrained programming for optimal water use in Karnal region. Proceedings International Symposium on Water Resources Systems(1): IV-29

Anonymous, 1950: Hormonal Treatment Of Rheumatoid Arthritis. Canadian Medical Association Journal 63(6): 604-605

Bean, S.F.; Jordon, R.E., 1974: Chronic nonhereditary blistering disease in children. Archives of Dermatology 110(6): 941-944

West, F.; Dawson, A.; Homer, C.S.E., 2017: Building midwifery educator capacity using international partnerships: Findings from a qualitative study. Midwifery educators play a critical role in strengthening the midwifery workforce globally, including in low and lower-middle income countries (LMIC) to ensure that midwives are adequately prepared to deliver quality midwifery care. The most effec...