+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain

, : Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain. Neurochemical Research 41(11): 3147-3159

NlmCategory="UNASSIGNED">Chemotherapy drugs such as vincristine (VCR) can cause neuropathic pain, and there is still lack of ideal strategy to treat it. The current study was designed to investigate effect of matrine (MT) on VCR-induced neuropathic pain in animal model. VCR (75 μg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy model in mice. MT (15, 30 and 60 mg/kg, i.p.) and pregabalin (10 mg/kg, i.p.) were administered for 11 consecutive days. Various tests were performed to assess the degree of pain at different days (1, 6, 11, 16, and 21). Von Frey hair, hot plate, cold-plate and paw pressure tests were conducted to assess the degree of mechanical allodynia, thermal hyperalgesia, cold allodynia and mechanical hyperalgesia in the hind paw respectively. The electrophysiological and histopathological changes were also analyzed. Furthermore, tissue malondialdehyde (MDA), total antioxidant capacity (T-AOC),superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total calcium (TCA), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10) were measured to investigate possible involvement of MT in inflammation and oxidative stress. Administration of MT attenuated the VCR-induced behavioral alterations as well as electrophysiological and histopathological changes in a dose dependent manner. Further, MT also attenuated the VCR-induced oxidative stress (MDA, T-AOC, GSH-Px, SOD and TCA) and inflammation (MPO, TNF-α, IL-6 and IL-10). Taken together, MT ameliorated VCR-induced painful neuropathy, which might be attributed to neuroprotective effects by subsequent reduction in oxidative stress and anti-inflammatory actions.


PMID: 27561290

DOI: 10.1007/s11064-016-2040-8

Other references

Qiu, H-Ou.; Yang, X-Qiu.; Yang, M.; Xi, Y-Qing.; Tang, Z-Yong., 2007: Enrichment of triphenyltin in water samples by beta-cyclodextrin cross-linking polymer and determination by hydride-generation atomic fluorescence spectrometry. A new method was proposed for the enrichment of triphenyltin in water samples by beta-cyclodextrin cross-linking polymer and the quantitative determination of tin in triphenyltin by hydride-generation atomic fluorescence spectrometry. The chemical...

Eltorki, M.; Uleryk, E.; Freedman, S.B., 2014: Waiver of informed consent in pediatric resuscitation research: a systematic review. In critical care and emergency medicine research, obtaining consent can be problematic when patients present with life-threatening conditions. This issue is further complicated in children, as even while coherent, they are often incapable of makin...

Fukamachi, H.; Takei, M.; Kawakami, T., 1993: Activation of multiple protein kinases including a MAP kinase upon Fc epsilon RI cross-linking. Previous studies have shown that protein-serine/threonine kinases and protein-tyrosine kinase(s) are activated by cross-linking of the high-affinity receptor for IgE, Fc epsilon RI, on mast cells and basophils. In vitro kinase assays (ISDR kinase...

Ecker, A.; Ledur, P.Christ.; da Silva, R.S.; Leal, D.Bitencourt.Rosa.; Rodrigues, O.E.D.; Ardisson-Araújo, D.; Waczuk, E.Pansera.; da Rocha, Jão.Batista.Teixeira.; Barbosa, N.Vargas., 2017: Chalcogenozidovudine Derivatives With Antitumor Activity: Comparative Toxicities in Cultured Human Mononuclear Cells. Considering a novel series of zidovudine (AZT) derivatives encompassing selenoaryl moieties promising candidates as therapeutics, we examined the toxicities elicited by AZT and derivatives 5'-(4-Chlorophenylseleno)zidovudine (SZ1); 5'-(P...

Kapitan, K.P.; Taran, V.M., 1976: Blunt abdominal trauma with prolapse of the ileum through the anus. Klinicheskaia Khirurgiia: 77-77

Morath, Edgar, 1937: Untersuchungen des Ein-flusses der Kiefernrassen und des Standortes auf die mechanischen Eigenschaften und den Harzgehalt der Stamme. Pine grown on sandstone conglomerate has greater sp. gr. and crushing strength than that grown on loess-basalt soil. Race (climatic variety) of tree makes little or no difference in mechanical properties, and neither race nor soil seems to affect...

Cesaro, A.N.; Granata, A., 1957: Quantitative hemocytochemical researches on occupational silicosis, saturnism, benzlism, carbon disulfide & carbon monoxide poisoning. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale 18(4): 413-427

Liebermann Robert C., 1970: Velocity-density systematics for the olivine and spinel phases of mg 2 sio 4 -fe 2 sio 4. Journal of Geophysical Research 75(20): 4029-4034

Gao, Y.; Li, G., 2003: Biochemical genetic analyze of isozymes from Patinopecten yessoensis. Dalian Shuichan Xueyuan Xuebao. Dec; 184: 269-272

Milstein, B.B.; Brock, R., 1954: Ventricular fibrillation during cardiac surgery. Guy's Hospital Reports 103(3): 213-259