+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Nutraceutical for Autosomal Dominant Polycystic Kidney Disease Therapy

, : Nutraceutical for Autosomal Dominant Polycystic Kidney Disease Therapy. Journal of the Medical Association of Thailand 99 Suppl 1: S97-103

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder caused by mutations of either PKD1 or PKD2 gene. Cyst formation initiates from a combination of abnormal cell proliferation along with enhanced fluid secretion. ADPKD is characterized by the progressive enlargement of cysts which destroy the renal parenchymal cells, resulting in renal failure. Currently, there is no effective treatment for this disease. Interestingly, several relevant therapeutic effects of herbal medicine relevant to pathogenic process of ADPKD have urged the researchers to search for potential candidate herb as nutraceutical for ADPKD therapy. Up to now, several natural compounds, such as triptolide, curcumin, ginkolide B, and steviol (stevia extract) have been shown to be able to retard cyst progression in ADPKD. The detailed mechanism of these compounds showed that triptolide enhanced calcium restoration, curcumin inhibited ERK & p-STAT3 pathways, ginkolide B inhibited Ras/MAPK pathway, and steviol activated AMPK, which inhibited CFTR channel and mTOR pathway in cell and mouse models of PKD. In addition, they are currently inpreclinical and clinical studies, respectively. This review focuses on the pathophysiology of ADPKD and the recent therapeutic approaches, especially a potential use of nutraceutical for the treatment of autosomal dominant polycystic kidney disease.


PMID: 26817244

Other references

Ishii, Yutaka; Sumi, Takahiko, 1993: Effects of tricyclic antidepressants on efflux of endogenous neurotransmitters from brain slices of rats. Japanese Journal of Pharmacology 61(SUPPL 1): 251P

Merimee, T.J.; Hollander, W.; Fineberg, S.E., 1972: Studies of hyperlipidemia in the HGH-deficient state. Metabolism: Clinical and Experimental 21(11): 1053-1061

Fowler, H.W., 1920: Description of a new Cyprinoid Fish (Notropis stonei), with notes on other Fishes obtained in the United States. Proceedings of the Academy of Natural Sciences of Philadelphia, 72 385-402

Mrosovsky, N.; Salmon, P.A.; Menaker, M.; Ralph, M.R., 1992: Nonphotic phase shifting in hamster clock mutants. Golden hamsters with the tau mutation were kept in the dark and induced to become active through confinement to a novel running wheel for 3 hr. The response of the mutants to this nonphotic phase-shifting stimulus differed from that of wild-type h...

Levy, J.L.; Elbhar, C.; Pizzi, M., 2001: Resultats des lasers vasculaires sur les telangiectasies des membres inferieurs. The authors treated lower limb telangiectasia using three successive technologies: KTP 532 nm, Nd : YAG 1064 nm and 595 nm long pulse dye lasers, comparing them with different sclerotherapeutic protocols. The results showed that today's laser...

Muller, L., 1955: Obituary by Hellmich, W. (2). Unknown

Rangachari, P.K., 2004: Caring for students: A teacher's view. The asymmetry in power relations that exist between physicians and patients also exist between teachers and students. Thus, the dimensions of student care are analogous to those of patient care. The interactions between teachers and students are a...

Carter, N.D.; Tanis, R.J.; Tashian, R.E.; Ferrell, R.E., 1973: Characterization of a new variant of human red cell carbonic anhydrase i f london glutamine 102 lysine. Biochemical Genetics 10(4): 399-408

Panagiotakos, D.B.; Pitsavos, C.; Chrysohoou, C.; Stefanadis, C.; Toutouzas, P., 2004: Primary prevention of acute coronary events through the adoption of a Mediterranean-style diet. We evaluated the role of a Mediterranean-style diet in preventing acute coronary syndromes (ACS). Data from CARDIO2000, a multi-centre retrospective case-control study investigating the association between ACS and demographic, nutritional, lifesty...

Baehrecke, M.; Schubert, W., 1980: Depressed skull fractures. Zeitschrift für Arztliche Fortbildung 74(12): 585-587