+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Oncolytic virotherapy for ovarian cancer

, : Oncolytic virotherapy for ovarian cancer. Oncolytic ViroTherapy 1(): 1-21

NlmCategory="UNASSIGNED">In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies. So far, nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients with recurrent ovarian cancers. In this article, we summarize the different OVs that are being assessed as therapeutics for ovarian cancer. We also present an overview of recent advances in identification of key genetic or immune-response pathways involved in tumorigenesis of ovarian cancer, which provides a better understanding of the tumor specificities and oncolytic properties of OVs. In addition, we discuss how next-generation OVs could be genetically modified or integrated into multimodality regimens to improve clinical outcomes based on recent advances in ovarian cancer biology.


PMID: 25977900

Other references

Svele, G.R., 1977: Occupational health services. III. Nurses and strikes. Sykepleien 64(7): 384, 388-384, 388

Bradbury Scott E.; Williams Quentin, 1998: Infrared spectra of clinozoisite and topaz to 20 GPa. Eos, Transactions, American Geophysical Union 79(45, Suppl

Fure S.; Romaniec M.; Emilson C.G.; Krasse B., 1987: Proportions of streptococcus mutans lactobacilli and actinomyces spp in root surface plague. The incidence of Streptococcus mutans lactobacilli and Actinomyces was examined in root surface dental plaque from 24 subjects with root surface caries and in 24 subjects with exposed root surfaces as a consequence of periodontitis but wthout root...

Van Aken, B., 2009: Transgenic plants for enhanced phytoremediation of toxic explosives. Phytoremediation of organic pollutants, such as explosives, is often a slow and incomplete process, potentially leading to the accumulation of toxic metabolites that can be further introduced into the food chain. During the past decade, plants hav...

Van der Graaff, M.; Kuiper, T.; Zwinderman, A.; Van de Warrenburg, B.; Poels, P.; Offeringa, A.; Van der Kooi, A.; Speelman, H.; D.V.sser, M., 2009: Clinical identification of dysarthria types among neurologists, residents in neurology and speech therapists. Classification of dysarthria types comprises flaccid, spastic, ataxic, hypo- and hyperkinetic and mixed dysarthria. This study focussed on the ability of neurologists to clinically identify the correct type of dysarthria in neurological patients....

Gámbaro, A.; Raggio, L.; Dauber, C.; Claudia Ellis, A.; Toribio, Z., 2013: Nutritional knowledge and consumption frequency of foods--a case study. The relationship between nutritional knowledge and the consumption frequency of preferred food-types was studied among one sample of Uruguayan consumers. A locally-adapted version of Parmenter & Wardle's General Nutrition Knowledge Questi...

Segel, R.; Silverstein, S.; Lerer, I.I.; Kahana, E.; Meir, R.; Sagi, M.; Zilber, N.; Korczyn, A.D.; Shapira, Y.; Argov, Z.; Carmi, R.; Falik, Z.; Ligum, C.; Frydman, M.; Gelman Kahan, Z.; Shalev, S.; Finkelstein, Y., 2002: The prevalence of myotonic dystrophy in Israeli Jewish communities Intercommunity variation and founder premutations. Neurology 58(7 Supplement 3): A226, April 9

Kerr, R.A., 2001: Planetary science. Strange doings on a NEAR-struck asteroid. Science 291(5508): 1467-1469

Anonymous, 1991: Killing the crisis, not the animals. Speakers discuss various aspects of animal welfare such as animal sterilization, animal overpopulation, and ways to combat cruelty to animals.

Freeman C.E.; Stiles F.G., 1992: Patterns in floral nectar sugar characters of some bird visited species from costa rica. American Journal of Botany 79(6 SUPPL): 183