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Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinoma

, : Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinoma. Biomedicine & PharmacoTherapy 69(): 409-415

Wiskott-Aldrich syndrome verprolin-homologous (WAVE) 3 has been reported to be implicated in various malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. The aim of this study was to investigate the effect of WAVE3 on the behaviors of HCC cells and to evaluate its clinical impact. A total of 120 paired of HCC and adjacent non-cancerous tissues were used to detect expression pattern of WAVE3 by immunohistochemistry. Then, the associations of WAVE3 expression with clinicopathologic characteristics and patients' prognosis were examined. The roles of WAVE3 in migration and invasion of HCC cell line HepG2 were also evaluated in vitro. Positive immunostaining of WAVE3 protein was predominantly observed in the cytoplasm of HCC cells. Compared to adjacent non-cancerous tissues, the expression levels of WAVE3 protein were significantly upregulated in HCC tissues (P<0.001). Additionally, high WAVE3 expression was significantly associated with advanced tumor stage (P=0.008) and positive distant metastasis (P=0.001). Then, high WAVE3 expression correlated significantly with poor prognosis, and WAVE3 status was identified as an independent significant prognostic factor. Moreover, small interfering RNA targeting WAVE3 was used to inhibit the expression of WAVE3 in HepG2 cells. We found that suppression of WAVE3 could inhibit migration and invasion of HepG2 cells. Our clinical study have characterized WAVE3 as biomarker for HCC progression and metastasis, and more importantly, have identified it as an independent prognostic marker for HCC patients. Our data also indicated that WAVE3 is pivotal in controlling oncogenic phenotypes of human HCC cells.


PMID: 25661390

DOI: 10.1016/j.biopha.2014.11.001

Other references

Gates J.A.; Bass J.T.; Hait W.N., 1985: Comparison of calmodulin purified from rat cerebrum and rat astrocytoma cells. Clinical Research 33(2 PART 1): 451A

Yuan, S.; Zhang, Z-Wei.; Zheng, C.; Zhao, Z-Yi.; Wang, Y.; Feng, L-Yang.; Niu, G.; Wang, C-Quan.; Wang, J-Hui.; Feng, H.; Xu, F.; Bao, F.; Hu, Y.; Cao, Y.; Ma, L.; Wang, H.; Kong, D-Dong.; Xiao, W.; Lin, H-Hui.; He, Y., 2016: Arabidopsis cryptochrome 1 functions in nitrogen regulation of flowering. The phenomenon of delayed flowering after the application of nitrogen (N) fertilizer has long been known in agriculture, but the detailed molecular basis for this phenomenon is largely unclear. Here we used a modified method of suppression-subtrac...

Tian, T.; Xiao, H.; Zhou, X., 2016: A Review: G-Quadruplex's Applications in Biological Target Detection and Drug Delivery. The G-quadruplex is one of the most important DNA secondary structures and has elicited widespread interest in this field of scientific research. As G-quadruplex studies have progressed, its significant roles in a variety of biological process hav...

D.W.ele, B.; Lauwers, M-Helen.; Massaad, D.; D.V.gelaere, K.; Delvaux, G., 2011: Outpatient gastroplasty for morbid obesity: our first hundred cases. Laparoscopic adjustable gastric banding (LAGB) is a safe and effective treatment for morbid obesity. The aim of the present study was to identify factors actually contributing to the feasibility or to the failure of performing this procedure in an...

McCrea, M.W.; Miller, A.S.; Rosenthal, S.L., 1968: Intraoral blue nevi. Report of two additional cases. Oral Surgery, Oral Medicine, and Oral Pathology 25(4): 590-593

Sparreboom, A.; Nooter, K.; Loos, W., J.; Verweij, J., 2001: The (ir)relevance of plasma protein binding of anticancer drugs. The major purpose of therapeutic drug monitoring is to enable drug dosage individualization for differences among patients in rates of drug metabolism and/or excretion. The standard analytical methods for measuring concentrations of drugs in plasm...

Yamauchi N.; Minamide T., 1985: Chlorophyll degradation by peroxidase in parsley leaves. The mechanism of chlorophyll by peroxidase in parsley leaves was studied. Chlorophylls present in the ethyl alcohol (EtOH) extract of parsley leaves were degraded by a peroxidase-hydrogen peroxide system. Purified chlorophylls, however, were not a...

Combs, D.R.; Penn, D.L.; Michael, C.O.; Basso, M.R.; Wiedeman, R.; Siebenmorgan, M.; Tiegreen, J.; Chapman, D., 2009: Perceptions of hostility by persons with and without persecutory delusions. Current models of paranoia propose that ambiguous situations, in which cues regarding the intentions of others are lacking, may be perceived as hostile by persons with persecutory delusions (PD). Thus, a social-cognitive bias for the perception of...

Campbell, J.F.; Lin, B.; Nehrir, A.R.; Harrison, F.Wallace.; Obland, M.D., 2014: High-resolution CW lidar altimetry using repeating intensity-modulated waveforms and Fourier transform reordering. An interpolation method is described for range measurements of high precision and altimetry using repeating intensity-modulated continuous wave (IM-CW) lidar waveforms, where the range is determined by means of a cross-correlation between the digi...

Holmes, D., 2014: Ole Petter Ottersen: on health and wealth. Lancet 383(9917): 593-593