+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer

, : Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer. American Journal of Cancer Research 5(9): 2788-2798

The aims of this study were to determine if Thioredoxin reductase (TR) is detected in the serum, and to establish the sensitivity and specificity of serum TR for diagnosing prostate cancer (PC). We assessed serum TR in 380 participants in the training cohort: 160 patients with PC, 120 with benign prostatic hyperplasia and 100 healthy individuals. The validation cohort comprised 320 participants: 120 with PC, 100 with BPH and 100 healthy individuals. TR was measured in serum by ELISA by independent researchers. The patients with PC were graded using the Gleason system. Receiver operating characteristic (ROC) curves were utilized to evaluate the accuracy of biomarkers to diagnose PC. The influence of serum levels of TR on tumor grade and metastasis was performed by binary logistic regression analysis. The median levels of serum TR in PC were significantly higher than that of healthy subjects and patients with BPH (P < 0.0001). Based on the ROC curve, the optimal cutoff value of serum TR levels as an indicator for auxiliary diagnosis of PC from BPH was projected to be 8.2 U/ml, which yielded a sensitivity of 81.8% and a specificity of 68.9%, with the area under the curve at 0.862 (95% CI, 0.821-0.903). Combined model (TR and PSA) showed a significantly greater discriminatory ability as compared with those markers alone. In regression analysis, after adjusting for other significant predictors, TR remained an independent metastasis predictor with an adjusted OR of 4.99 (95% CI, 2.64-8.09). Similarly, TR also was an independent High-grade tumors (HGT) predictor with an adjusted OR of 5.15 (95% CI, 2.52-9.14). Our study has demonstrated the additional benefit of TR measurement in the diagnosis of PC in the Chinese population. Further studies of the application of TR in this region may be beneficial.


PMID: 26609484

Other references

Barsanti, J.A., 1984: Diagnostic procedures in urology. Veterinary Clinics of North America. Small Animal Practice 14(1): 3-14

Norheim, O.F., 1995: The Norwegian welfare state in transition: rationing and plurality of values as ethical challenges for the health care system. This paper presents the Norwegian national health care system and the manner in which the problems of rationing and pluralism of values create new ethical and political challenges. The paper concludes with some doubts about the feasibility of the...

Palen, W.J.; Schindler, D.E.; Adams, M.J., 2004: Optical characteristics of natural waters protect amphibians from UV-B in the U.S. Pacific Northwest: Reply. Ecology 85(6): 54-9

Kaplan, R.I., 1973: The dental profession and unions. Journal of the American College of Dentists 40(3): 142-143

Rumpenhorst, Hj, 1973: Studies on the occurrence of pathotypes of the potato cyst nematodes Heterodera rostochiensis and Heterodera pallida in the Federal Republic of Germany. Mitteilungen aus der Biologischen Bundesanstalt feur Land und Forstwirtschaft Berlin Dahlem 151 294-295

Del Claro, K.; Oliveira, P.S., 2000: Conditional outcomes in a neotropical treehopper-ant association: Temporal and species-specific variation in ant protection and homopteran fecundity. We studied the association between the honeydew-producing membracid Guayaquila xiphias and its tending ants in the cerrado savanna of Brazil, during 1992 and 1993. Results showed that ants attack potential enemies of G. xiphias, and that increased...

Peterson, E.B.; Ostroff, J.S.; DuHamel, K.N.; D'Agostino, T.A.; Hernandez, M.; Canzona, M.R.; Bylund, C.L., 2016: Impact of provider-patient communication on cancer screening adherence: A systematic review. NlmCategory="UNASSIGNED">Cancer screening is critical for early detection and a lack of screening is associated with late-stage diagnosis and lower survival rates. The goal of this review was to analyze studies that focused on the rol...

Bours J., 1977: The iso electric focusing and isotachophoresis of the crystallins of the aging mouse lens. Experimental Eye Research 25(5): 530

Savitskaya, N.V.; Gortinskaya, T.V.; Nyrkova, V.G.; Fedorova, I.N., 1977: Some transformations of 3 4 di aza phenoxazine derivatives in the vilsmeier reaction. In connection with the accessibility of 3,4-diazaphenoxazine derivatives to the reaction of electrophilic substitution, 2-chloro-10-dialkylaminoalkyl(or 10-alkyl)-3,4-diazaphenoxazines and their 7- or 8-substituted 3,4-diazaphenoxazine were transf...

Bakopoulou, A.; Leyhausen, G.; Volk, J.; Tsiftsoglou, A.; Garefis, P.; Koidis, P.; Geurtsen, W., 2011: Assessment of the impact of two different isolation methods on the osteo/odontogenic differentiation potential of human dental stem cells derived from deciduous teeth. Human deciduous teeth have been proposed as a promising source of mesenchymal stem cells for application in bone and dental tissue engineering. We established cultures of mesenchymal stem cells from the pulp of human deciduous teeth (deciduous tee...