geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR


, : Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR. Orthopaedic Journal of Sports Medicine 4(4): 2325967116644421-2325967116644421

The effectiveness of anterior cruciate ligament (ACL) reconstruction in preventing early osteoarthritis is debated. Restoring the original biomechanics may potentially prevent degeneration, but apparent pathomechanisms have yet to be described. Newer quantitative magnetic resonance (qMR) imaging techniques, specifically T1ρ and T2, offer novel, noninvasive methods of visualizing and quantifying early cartilage degeneration. To determine the tibiofemoral biomechanical alterations before and after ACL reconstruction using magnetic resonance imaging (MRI) and to evaluate the association between biomechanics and cartilage degeneration using T1ρ and T2. Cohort study; Level of evidence, 2. Knee MRIs of 51 individuals (mean age, 29.5 ± 8.4 years) with unilateral ACL injuries were obtained prior to surgery; 19 control subjects (mean age, 30.7 ± 5.3 years) were also scanned. Follow-up MRIs were obtained at 6 months and 1 year. Tibial position (TP), internal tibial rotation (ITR), and T1ρ and T2 were calculated using an in-house Matlab program. Student t tests, repeated measures, and regression models were used to compare differences between injured and uninjured sides, observe longitudinal changes, and evaluate correlations between TP, ITR, and T1ρ and T2. TP was significantly more anterior on the injured side at all time points (P < .001). ITR was significantly increased on the injured side prior to surgery (P = .033). At 1 year, a more anterior TP was associated with elevated T1ρ (P = .002) and T2 (P = .026) in the posterolateral tibia and with decreased T2 in the central lateral femur (P = .048); ITR was associated with increased T1ρ in the posteromedial femur (P = .009). ITR at 6 months was associated with increased T1ρ at 1 year in the posteromedial tibia (P = .029). Persistent biomechanical alterations after ACL reconstruction are related to significant changes in cartilage T1ρ and T2 at 1 year postreconstruction. Longitudinal correlations between ITR and T1ρ suggest that these alterations may be indicative of future cartilage injury, leading to degeneration and osteoarthritis. Newer surgical techniques should be developed to eliminate the persistent anterior tibial translation commonly seen after ACL reconstruction. qMR will be a useful tool to evaluate the ability of these newer techniques to prevent cartilage changes.

US$19.90

PMID: 27169133

DOI: 10.1177/2325967116644421


Other references

Ma, G.; Feineis, S.; Osterrieder, N.; Van de Walle, G.R., 2012: Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I. Major histocompatibility complex class I (MHC-I) molecules play an important role in host immunity to infection by presenting antigenic peptides to cytotoxic T lymphocytes (CTLs), which recognize and destroy virus-infected cells. Members of the He...

Marlin S.G.; Cynader M.S., 1986: Direction selective adaptation of cat striate cortex cells. Investigative Ophthalmology & Visual Science 27(3 SUPPL): 244

Gonzalez, L.E.; Rojnik, B.; Urdaneta, H.; Hernandez, L., 2001: Rats infected with Toxoplasma gondii are highly risk-taking. We explore whether the Toxoplasma gondii (T gondii) could alter anxiety related behaviors in two ethological and validated models of anxiety. Rats were inoculated IP with Vehicle (V), 100 Tachyzoites (T100) or 1000 Tachyzoites (T1000) and tested t...

Grant, L.; Becker, F.F., 1965: Mechanisms of inflammation. I. Laser-induced thrombosis, a morphologic analysis. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 119(4): 1123-1129

Wendling, F.; Debili, N.; Katz, A.; Guichard, J.; Breton Gorius, J.; Hunt, P.; Vainchenker, W., 1995: The Mpl-L has both direct proliferative and differentiative activities on human MK progenitors. Experimental Hematology (Charlottesville) 23(8): 829

Gloor, P., 1983: Various aspects of the physiology and pathophysiology of spindles in the cat. Spindles are a thalamocortical rhythm entirely dependent upon a thalamic mechanism. Generators of cortical spindle waves are the pyramidal neurons of the cortex. A positive statistical relationship exists between postsynaptic excitatory events of...

Colomer Jordi; Fernando Harindra J.S., 1996: Resuspension of particle bed by round vertical jet. Journal of Environmental Engineering 122(9): 864-869

Burtscher, M.J.; Wacker, J.; Grote, G.; Manser, T., 2010: Managing nonroutine events in anesthesia: the role of adaptive coordination. This field study aimed at examining the role of anesthesia teams' adaptive coordination in managing changing situational demands, such as in nonroutine events (NREs). Medical teams' ability to adapt their teamwork (e.g., their coordinati...

Filloux J.F.; Breuillard F.; Obry C.; Vives P., 1991: Amelanotic ungueal melanoma a case report. Annales de Chirurgie de la Main et du Membre Superieur 10(2): 181-183

Spedding, A., 1992: Calf rearing practice at the National Agricultural Centre Beef and Calf Unit. BSAP occasional ication: an occasional ication of the British Society of Animal Production: 5) 145-147