+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pervasive Selection for Cooperative Cross-Feeding in Bacterial Communities

, : Pervasive Selection for Cooperative Cross-Feeding in Bacterial Communities. Plos Computational Biology 12(6): E1004986-E1004986

Bacterial communities are taxonomically highly diverse, yet the mechanisms that maintain this diversity remain poorly understood. We hypothesized that an obligate and mutual exchange of metabolites, as is very common among bacterial cells, could stabilize different genotypes within microbial communities. To test this, we developed a cellular automaton to model interactions among six empirically characterized genotypes that differ in their ability and propensity to produce amino acids. By systematically varying intrinsic (i.e. benefit-to-cost ratio) and extrinsic parameters (i.e. metabolite diffusion level, environmental amino acid availability), we show that obligate cross-feeding of essential metabolites is selected for under a broad range of conditions. In spatially structured environments, positive assortment among cross-feeders resulted in the formation of cooperative clusters, which limited exploitation by non-producing auxotrophs, yet allowed them to persist at the clusters' periphery. Strikingly, cross-feeding helped to maintain genotypic diversity within populations, while amino acid supplementation to the environment decoupled obligate interactions and favored auxotrophic cells that saved amino acid production costs over metabolically autonomous prototrophs. Together, our results suggest that spatially structured environments and limited nutrient availabilities should facilitate the evolution of metabolic interactions, which can help to maintain genotypic diversity within natural microbial populations.


PMID: 27314840

DOI: 10.1371/journal.pcbi.1004986

Other references

Song, B.; Oswald, G.; Zhao, J.; Lippert, B.; Sigel, H., 2001: Quantification of Outer-Sphere Macrochelate Formation in the Ternary cis-Diammine-Platinum(II)-Bis-2'-deoxyguanosine 5'-Monophosphate Complex, cis-(NH(3))(2)Pt(dGMP)(2)(2)(-), and Formation of Quaternary Mixed Metal Ion Species with Magnesium(II), Copper(II), or Zinc(II) in Aqueous Solution. The acid-base properties of cis-(NH(3))(2)Pt(dG)(2)(2)(-), where both dG(2)(-) (=2'-deoxyguanosine 5'-monophosphate) are N7-coordinated to the same Pt(II) [the complex is abbreviated as Pt(dG)(2)(2)(-)], are summarized [on the basis of p...

Lytle,R.; Lavay,B.; Rizzo,T., 2010: What is a highly qualified adapted physical education teacher?. This paper explains the characteristics of a highly qualified adapted physical educator. It addresses some of the specific content knowledge areas and the guiding principles necessary to be an adapted physical educator.

Alvarez, R.C.; Nissen, S.J.; Ernst, S.G., 1994: Selection, enrichment and initial characterization of an elongated cell culture of tobacco. When tobacco NT-1 (Nicotiana tabacum L. cv. Bright Yellow) cells were grown under stationary conditions in the dark, a subset of the cells formed linear chains, each cell being approximately 2-5 times more elongated along one axis. When enriched c...

Ernst, D.; Pfeiffer, F.; Schefbeck, K.; Weyrauch, C.; Oesterhelt, D., 1987: Phytochrome regulation of mRNA levels of ribulose-1,5-bisphosphate carboxylase in etiolated rye seedlings (Secale cereale). The effect of red light and far-red light on the appearance of mRNA for the small and large subunit of ribulose-1,5-bisphosphate carboxylase in rye seedlings has been analysed. Irradiation of etiolated seedlings with a pulse of red light increased...

Divall, G.B.; Ismail, M., 1983: Lactate dehydrogenase ec isozymes in vaginal swab extracts a problem for the identification of menstrual blood. Extracts of vaginal swabs free of both blood and semen, collected from 3 donors throughout several menstrual cycles, was examined by cellulose acetate membrane electrophoresis for the presence of lactate dehydrogenase (LDH) isozymes. LDH activity,...

Gajewski, D., 1968: Relationship between bovine mastitis and the bacterial contamination of meat. Of 357 cattle examined 146 were cows with mastitis and the remaining 211 were mastitis-free controls. The udders of the former group yielded 108 strains of Staphylococcus, 14 strains of Streptococcus and two coliform organisms. Other tissues of th...

Pagani, P.A.; Galliani Lullini, I., 1966: Mitotic activity of fibroblasts and myoblasts cultivated in vitro irradiated with Co60. Bollettino Della Societa Italiana di Biologia Sperimentale 42(4): 145-146

Cozzaglio Arturo, 1934: Del sollevamento epirico tra lAdda e lAdige. Physiography of the Brembo-Adige region, Italy.

Lax, Y.; Rubinstein, S.; Breitbart, H., 1997: Subcellular distribution of protein kinase C alpha and betaI in bovine spermatozoa, and their regulation by calcium and phorbol esters. Protein kinase C (PKC), the major cell target for tumor-promoting phorbol esters, is central to many signal transduction pathways. Previously we have demonstrated the presence of PKC in ram and bovine spermatozoa. However, the relative distributio...

Wang, J.; Cao, W.; Niu, F., 2016: Adenoviral vector expressing IGF-1 protects murine chondrogenic ATDC5 cells against hydrogen peroxide-induced mitochondrial dysfunction and apoptosis. Insulin-like growth factor-1 (IGF-1), with an age-related decline, regulates the proliferation and survival of multiple cell types, particularly stimulates cartilage matrix synthesis, and inhibits matrix degradation. The present study was to inves...