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Photo-controllable intermittent release of doxorubicin hydrochloride from liposomes embedded by azobenzene-contained glycolipid

, : Photo-controllable intermittent release of doxorubicin hydrochloride from liposomes embedded by azobenzene-contained glycolipid. Langmuir

NlmCategory="UNASSIGNED">Azobenzene-contained glycolipids GlyAzoCns, newly structured azobenzene derivatives, which have an azobenzene moiety between the galactosyl and carbon chains of various sizes, have been synthesized. The GlyAzoCns undergo reversible photo-induced isomerization in both ethanol solution (free state) and liposomal bilayer (restricted state) upon irradiation with UV and Vis-light alternately. The drug release of Liposome@Gly induced by isomerization was found to be an instantaneous behavior. The photo-induced control of DOX release from liposome was investigated in various modes. The Liposome@Glys have been found to keep the entrapped DOX stably in dark with less than 10 % leakage in 10 h but release nearly 100 % of cargos instantaneously with UV-irradiation. Molecular structure of GlyAzoCns and property of liposomal bilayer were considered as important factors influencing drug release. Among the synthesized GlyAzoCns, GlyAzoC7 showed to be the most efficient photosensitive actuator for controlling drug release. A lower proportion of cholesterol in Liposome@Glys was conducive to promote the release amount. Results indicated that the synthesized GlyAzoCns could act as a role of smart actuators in the liposome bilayer and control the drug to release temporarily and quantitatively.


PMID: 27668306

DOI: 10.1021/acs.langmuir.6b03051

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