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Phototoxic potential of silymarin and its bioactive components


, : Phototoxic potential of silymarin and its bioactive components. Journal of Photochemistry and Photobiology. B, Biology 156: 61-68

Silymarin, a standardized extract of the seeds of the milk thistle (Silybum marianum) and its major component, silybin, is now used as an active component in a broad spectrum of dietary supplements, cosmetics and dermatological preparations. However, despite its use in skin products, there are no published data to exclude its phototoxic potential. The primary purpose of this study was to examine the phototoxicity of silymarin and its flavonolignans, silybin, isosilybin, silychristin, silydianin and 2,3-dehydrosilybin by validated 3T3 NRU assay. Further, we compared the validated biological system Balc/c 3T3 cell line with other cell models, particularly normal human dermal fibroblasts (NHDF), normal human epidermal keratinocytes (NHEK) and the human keratinocyte cell line (HaCaT). The results showed that silymarin and the flavonolignans silybin, isosilybin, silychristin and silydianin had no phototoxicity towards any of the cells used. In contrast, 2,3-dehydrosilybin was identified as a compound with phototoxic potential. Further study is needed to evaluate the health risks associated with 2,3-dehydrosilybin use in skin preparations.

US$19.90

PMID: 26851710

DOI: 10.1016/j.jphotobiol.2016.01.011


Other references

Cohen, J.D.; Patton, E.A.; Badger, T.L., 1952: The tuberculous mother; a five- to twenty-year follow-up of 149 women with 401 full-term pregnancies. American Review of Tuberculosis 65(1:1): 1-23

Cho, H-Jun.; Kim, C-Bo., 2004: Discolored nasal discharge did not increase the antibiotic prescription rate for the common cold patients. Pharmacoepidemiology and Drug Safety 14(2): 139-141

Bolton, T., 1998: The international paper trade. The whole spectrum of the pulp and paper industry is discussed. Chapters 1-4 give a brief outline of the history and the technology of the industry covering the production, consumption, import and export levels in the major regions of the world ov...

Dermitzakis, K.; Morales, M.Roberto.; Schweizer, A., 2013: Modeling the frictional interaction in the tendon-pulley system of the human finger for use in robotics. Physiological studies of the human finger indicate that friction in the tendon-pulley system accounts for a considerable fraction of the total output force (9-12%) in a high-load static posteccentric configuration. Such a phenomenon can be exploit...

Longest, P.Worth.; Son, Y-Ju.; Holbrook, L.; Hindle, M., 2014: Aerodynamic factors responsible for the deaggregation of carrier-free drug powders to form micrometer and submicrometer aerosols. To employ <em>in vitro</em> experiments combined with computational fluid dynamics (CFD) analysis to determine which aerodynamic factors were most responsible for deaggregating carrier-free powders to form micrometer and submicrometer...

Lin, Q.; Li, Y.; Li, M.; Huang, K-Ming., 2013: The optimation of extraction technology of chuanxiong and xiangfu compatibility by SFE-CO2. To optimize the extraction conditions of Chuanxiong and Xiangfu compatibility by supercritical CO2 and control the quality of the extract. The orthogonal design experiments were used to select the optimal conditions and the factors were extraction...

Montazeri, A., 1996: Clinical Oncology Information Network: is the need urgent?. Clinical Oncology ) 8(2): 132-132

Baron, V.A.; Tokarev, N.I., 1979: Calculation of the equilibrium composition of the soil solution and solid salt phase from data on the water extract. The real composition of the ion-salt complex of soils is calculated by a method based on the minimization of free energy in the equilibrium state. This method can be used to determine the steady composition of the ion-salt complex and also to redu...

Esmaeli, S.; Allameh, A.; Adelipour, M.; Soleimani, M.; Allameh, M., 2017: The impact of oxidative DNA changes and ATM expression on morphological and functional activities on hepatocytes obtained from mesenchymal stem cells. Resistance to oxidative damages in undifferentiated mesenchymal stem cells (MSCs) in comparison with the undifferentiated progenitor cells may differ depending on several factors. This study was carried out to examine the impact of hepatogenic dif...

Kjaergaard, J.; Starklint, H.; Bierring, F.; Thybo, E., 1977: Surface topography of the healthy and diseased transitional cell epithelium of the human urinary bladder. 51 biopsies from healthy and diseased epithelium from human urinary bladders were examined by scanning electron microscopy. The luminal surface of the cover cells was marked by microvilli and microplicae. The replacement of the cover cells takes p...